Lymphatic Enhancement Technology for Fibromyalgia

JZ
Overseen ByJason Zafereo, M.P.T, Ph.D.
Age: 18+
Sex: Female
Trial Phase: Academic
Sponsor: University of Texas Southwestern Medical Center
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial tests a new treatment called Lymphatic Enhancement Technology (LET) for individuals with fibromyalgia, a condition causing widespread pain and fatigue. The trial aims to determine if LET can reduce symptoms by using a machine that emits lights, sounds, and energy. Participants will receive either the actual LET treatment or a sham (fake) treatment for comparison. Women who meet the criteria for fibromyalgia and have not previously tried LET may be suitable candidates. As an unphased trial, this study provides a unique opportunity to explore innovative treatment options for fibromyalgia.

Do I need to stop taking my current medications for the trial?

You don't need to stop your current medications, but you must not change them within 14 days before starting the study or during the study.

What prior data suggests that Lymphatic Enhancement Technology is safe for fibromyalgia patients?

Research has shown that Lymphatic Enhancement Technology (LET) is generally safe. The FDA has approved LET for certain uses, indicating it has passed some safety checks.

Other studies have found that treatments similar to LET, such as gentle massage for fibromyalgia, are well-tolerated. These studies reported no major side effects, and patients managed the treatment without significant issues.

Although detailed safety data for LET in fibromyalgia is limited, the existing approval and related studies suggest LET is likely a safe option for those considering joining clinical trials.12345

Why are researchers excited about this trial?

Researchers are excited about Lymphatic Enhancement Technology (LET) for fibromyalgia because it introduces a unique approach by using a machine that emits lights, sounds, and electrostatic energy. Unlike standard treatments like medications or physical therapy, LET combines sensory stimulation with electrostatic energy, potentially enhancing lymphatic function and reducing symptoms. This innovative method could offer relief faster and with fewer side effects, providing a new hope for those struggling with fibromyalgia.

What evidence suggests that Lymphatic Enhancement Technology is effective for fibromyalgia?

Research shows that treatments targeting the lymphatic system can help alleviate fibromyalgia symptoms. Studies on manual lymphatic drainage (MLD), similar to Lymphatic Enhancement Technology (LET), have shown positive results. Specifically, MLD has reduced pain and improved the quality of life for people with fibromyalgia. In this trial, participants in the active LET group will receive treatment with a machine designed to boost lymphatic function, potentially offering similar benefits. Early findings suggest that LET may decrease pain and enhance overall well-being for those with fibromyalgia.13678

Who Is on the Research Team?

JZ

Jason Zafereo, M.P.T, Ph.D.

Principal Investigator

UT Southwestern Medical Center

Are You a Good Fit for This Trial?

This trial is for women aged 18-65 with moderate to severe fibromyalgia, as indicated by an FIQ score ≥39. Participants must meet the American College of Rheumatology's criteria for fibromyalgia and not have changed medications in the last 14 days. They cannot have had LET treatment before or be undergoing other mind-body treatments, and should not have a pacemaker, active blood clots, infections, heart failure, cancer treatments or recent steroid injections.

Inclusion Criteria

An FIQ score ≥39 (moderate severity)
Meeting the American College of Rheumatology 2016 diagnostic criteria for fibromyalgia
I am between 18 and 65 years old.
See 3 more

Exclusion Criteria

Currently receiving any other form of mind-body or exercise treatment
Presence of an implanted pacemaker
Pregnant or may be pregnant
See 6 more

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Participants complete baseline assessments including demographic information and medical history

1 week
1 visit (in-person)

Treatment

Participants receive four weekly treatments with either active or sham LET device

4 weeks
4 visits (in-person)

Follow-up

A follow-up phone call or email from the study team to assess outcomes

4 weeks
1 contact (virtual)

What Are the Treatments Tested in This Trial?

Interventions

  • Lymphatic Enhancement Technology (LET)
Trial Overview The study tests Lymphatic Enhancement Technology (LET) against a sham procedure to see if it helps with fibromyalgia symptoms. It's double-blinded so neither participants nor researchers know who gets real vs sham treatment. Participants receive weekly sessions over one month and complete quality-of-life surveys with follow-up after four weeks post-treatment.
How Is the Trial Designed?
2Treatment groups
Experimental Treatment
Placebo Group
Group I: Active LET groupExperimental Treatment1 Intervention
Group II: Sham LET groupPlacebo Group1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Texas Southwestern Medical Center

Lead Sponsor

Trials
1,102
Recruited
1,077,000+

Arcturus Star Products

Collaborator

Citations

Study Details | NCT07201818 | LET for FibromyalgiaThe purpose of this research study is to determine the effectiveness of Lymphatic Enhancement Technology (LET) treatment in patients with ...
Lymphatic Enhancement Technology for FibromyalgiaThe purpose of this research study is to determine the effectiveness of Lymphatic Enhancement Technology (LET) treatment in patients with fibromyalgia.
Effectiveness of manual lymphatic drainage in women with ...To analyse the efficacy of manual lymphatic drainage (MLD) as an alternative to traditional treatment of fibromyalgia (FM) in women.
4.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/39758039/
Effects of manual lymphatic drainage on pain intensity ...This study aimed to investigate the effectiveness of Manual Lymphatic Drainage (MLD) on the pain intensity, impact of the disease, and health-related quality ...
Effectiveness of manual lymphatic drainage in women with ...To analyse the efficacy of manual lymphatic drainage (MLD) as an alternative to traditional treatment of fibromyalgia (FM) in women. Methods. This was an ...
Whole-Body Photobiomodulation Therapy for FibromyalgiaSafety data were based on clinical symptoms and physiological variables. Trial duration spanned four seasons; hence, weather as a variable could not be ...
Safety and Effectiveness of Vibration Massage by Deep ...In conclusion, deep oscillation massage is safe and well tolerated in patients with FMS and might improve symptoms and quality of life rather ...
Manual lymph drainage therapy using light massage for ...Manual lymph drainage therapy using light massage for fibromyalgia sufferers: A pilot study ... Our data indicate that the oxytocinergic system ...
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