Rimegepant for Migraine
(RIM Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
Single-center, open label, prospective study conducted at Medstar Georgetown Headache Center. Men and woman ≥ 18 years old that are diagnosed with migraine with or without aura for at least 1 year, who report a reliable migraine trigger. Acceptable triggers for the study will include exercise, alcohol (less than one drink per day for woman and less than two drinks per day for men), air travel that lasts no more than 12 hours, sexual activity, fasting that lasts no more than 24 hours, stress or stress let-down headache.
Who Is on the Research Team?
Jessica Ailani, MD
Principal Investigator
MedStar's Georgetown University Hospital
Are You a Good Fit for This Trial?
This trial is for adults over 18 in the US with a history of migraines triggered by specific activities like exercise, moderate alcohol consumption, air travel up to 12 hours, sexual activity, fasting up to 24 hours, or stress. Participants should have had migraines for at least a year and experience them frequently enough to distinguish from other headaches.Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive preemptive treatment with Rimegepant for predictable trigger-induced migraine
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Rimegepant
Trial Overview
The study tests Rimegepant 75 MG as a preemptive treatment for migraines induced by predictable triggers. It's an open-label trial where all participants know they're receiving the medication and are monitored at Medstar Georgetown Headache Center.
How Is the Trial Designed?
1
Treatment groups
Experimental Treatment
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medstar Health Research Institute
Lead Sponsor
Pfizer
Industry Sponsor
Albert Bourla
Pfizer
Chief Executive Officer since 2019
PhD in Biotechnology of Reproduction, Aristotle University of Thessaloniki
Patrizia Cavazzoni
Pfizer
Chief Medical Officer
MD from McGill University
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