Neurophysiological Interventions for Bipolar Disorder

(BandR Trial)

Overseen By Greg Siegle

Age: 18+

Sex: Any

Trial Phase: Academic

Sponsor: University of Pittsburgh

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

Study to examine the extent to which neurophysiological states recorded for a specific person on one day can be induced on a subsequent day

Who Is on the Research Team?

Greg Siegle

Principal Investigator

University of Pittsburgh

Are You a Good Fit for This Trial?

Inclusion Criteria

Have periods of good and bad moods each lasting at least 2 days

I am between 18 and 65 years old.

Exclusion Criteria

Presence of frank psychotic episodes or inability to stay off psychoactive substances during assessments

Inability to complete questionnaires written in English

Refusal or inability to provide informed consent

What Are the Treatments Tested in This Trial?

Interventions

• Neuro/biofeedback

How Is the Trial Designed?

Group I: Recall + Stimulation + Neurofeedback Experimental Treatment 4 Interventions

Participants will be given their subjective ratings and notes from the first session and asked to recreate how they were feeling at their first session during recall-only blocks. In addition, during neurofeedback and stimulation blocks, they will be given access to technologies for restoring neurophysiological features from the first assessment, including their 1) brain state, 2) facial muscle activity, and 3) heart rate variability. They will be provided with this information and asked to match their previous recordings during the neurofeedback blocks, and stimulated using TACS, EMG, and vibroacoustic stimulation during the stimulation blocks.

Who Is Running the Clinical Trial?

University of Pittsburgh

Lead Sponsor

Trials

1,820

Recruited

16,360,000+