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Behavioural Intervention

Anodal Transcranial Direct Current Stimulation for Traumatic Brain Injury

Phase 2
Waitlist Available
Led By Tasha M Nienow, PhD
Research Sponsored by Minneapolis Veterans Affairs Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Be older than 18 years old
Timeline
Screening 3 weeks
Treatment Varies
Follow Up post-intervention, 8-9 weeks after baseline assessment
Awards & highlights

Study Summary

This trial aims to assess the effects of tDCS on patients with mild traumatic brain injury, identify biomarkers of treatment response, and measure acceptability/tolerability of the approach. EEGs will be used to measure neural efficiency before/after.

Who is the study for?
This trial is for veterans aged 18-65 who have had a mild traumatic brain injury over a year ago and are enrolled at the Minneapolis VA Health Care System. It's not for those with psychotic disorders, recent substance use issues, severe depression, other cognitive impairments, or medical conditions that don't allow TDCS.Check my eligibility
What is being tested?
The study tests if transcranial direct current stimulation (TDCS) can improve cognition in patients with mild traumatic brain injury. Participants will be randomly assigned to receive either real TDCS or sham stimulation alongside working memory training.See study design
What are the potential side effects?
Possible side effects of TDCS may include discomfort at the electrode site, itching or tingling during stimulation, headache, fatigue, nausea or dizziness. However, it's generally considered safe with minimal adverse effects.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~post-intervention, 8-9 weeks after baseline assessment
This trial's timeline: 3 weeks for screening, Varies for treatment, and post-intervention, 8-9 weeks after baseline assessment for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Wechsler Adult Intelligence Scale (WAIS)-III Working Memory Index
Secondary outcome measures
University of California Performance Based Skills Assessment
Other outcome measures
Resting state electroencephalogram (EEG)

Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: Transcranial Direct Current StimulationExperimental Treatment1 Intervention
Participants will receive 24 sessions (3 times a week) of anodal transcranial direct current stimulation concurrent with working memory training. Stimulation will be administered at 2 milliamps (mA) for 20 minutes over the left dorsal lateral prefrontal cortex.
Group II: ShamPlacebo Group1 Intervention
Participants will receive 24 sessions of working memory training. The experience of transcranial direct current stimulation will be simulated by administering 30 seconds of stimulation at the beginning of the session.

Find a Location

Who is running the clinical trial?

Minnesota Veterans Medical Research and Education FoundationOTHER
3 Previous Clinical Trials
131 Total Patients Enrolled
State of MinnesotaUNKNOWN
Minneapolis Veterans Affairs Medical CenterLead Sponsor
72 Previous Clinical Trials
14,879 Total Patients Enrolled

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury
Tasha Nienow 2016. "Transcranial Direct Current Stimulation (TDCS) as an Intervention for Patients With Traumatic Brain Injury". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT02849223.
All > Trauma > Tdcs
~2 spots leftby Sep 2024
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