129 Xenon MRI for Pulmonary Arterial Hypertension
(Xenon PAH Bio Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What data supports the effectiveness of the treatment 129 Xenon MRI for Pulmonary Arterial Hypertension?
Research shows that Hyperpolarized 129 Xenon MRI can effectively assess lung function by evaluating ventilation and gas transfer, which are crucial for diagnosing and monitoring pulmonary vascular diseases. This imaging technique has demonstrated the ability to detect abnormalities in gas exchange in the lungs, suggesting its potential usefulness in managing conditions like pulmonary arterial hypertension.12345
Is 129 Xenon MRI safe for humans?
Research on hyperpolarized 129 Xenon MRI (HP 129 Xe MRI) suggests it is generally safe for use in humans, including children, as it has been used in studies for lung and brain imaging. However, its safety and tolerability, especially in children, have not been rigorously assessed, indicating more research is needed to fully understand its safety profile.12367
How does the 129 Xenon MRI treatment differ from other treatments for pulmonary arterial hypertension?
The 129 Xenon MRI treatment is unique because it uses a special type of imaging to assess lung function by evaluating both ventilation and gas transfer, which is not typically done with standard treatments for pulmonary arterial hypertension. This imaging technique can help in diagnosing and monitoring the condition by providing detailed insights into lung physiology.12345
What is the purpose of this trial?
The overall study objectives outlined in this study are to derive 129Xe MRI pulmonary vascular biomarker signatures that differentiate common subtypes of PAH and to determine the ability of 129Xe MRI to longitudinally monitor disease progression and response to therapy in PAH, with the aid of additional assessments, such as labs, echocardiography, and six-minute walk distance (6MWD).
Research Team
Fawaz Alenezi, MD
Principal Investigator
Duke Univeristy
Eligibility Criteria
This trial is for adults aged 18-75 with Pulmonary Arterial Hypertension (PAH), either idiopathic or associated with connective tissue disease. Participants must have specific heart and lung pressure measurements, be in WHO functional class 2 or 3, and not have other causes for PAH. Those unable to undergo a 129Xe MRI scan or with different types of pulmonary hypertension are excluded.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Baseline Assessment
Participants undergo baseline 129Xe MRI/MRS and standard of care assessments including labs, echocardiography, and six-minute walk distance (6MWD)
Longitudinal Monitoring
Participants undergo 129Xe MRI/MRS and standard of care assessments at 3, 6, and 12 months to monitor disease progression and response to therapy
Follow-up
Participants are monitored for safety and effectiveness after the main observation period
Treatment Details
Interventions
- 129 Xenon MRI
Find a Clinic Near You
Who Is Running the Clinical Trial?
Bastiaan Driehuys
Lead Sponsor
American Heart Association
Collaborator