Dolobid

Pain, Rheumatoid Arthritis, Osteoarthritis + 1 more
Treatment
5 FDA approvals
20 Active Studies for Dolobid

What is Dolobid

DiflunisalThe Generic name of this drug
Treatment SummaryDiflunisal is a nonsteroidal anti-inflammatory drug (NSAID) used to relieve pain and reduce inflammation associated with arthritis. It works by blocking certain substances in the body that lead to inflammation. Diflunisal is prescribed to treat rheumatoid arthritis and osteoarthritis.
Diflunisalis the brand name
image of different drug pills on a surface
Dolobid Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Diflunisal
Diflunisal
1992
17

Approved as Treatment by the FDA

Diflunisal, also known as Diflunisal, is approved by the FDA for 5 uses which include Osteoarthritis (OA) and Rheumatoid Arthritis .
Osteoarthritis (OA)
Rheumatoid Arthritis
Pain
Mild pain
Osteoarthritis

Effectiveness

How Dolobid Affects PatientsDiflunisal is a non-narcotic painkiller, anti-inflammatory, and fever reducer. It is not habit-forming and does not cause addiction. It is a slightly different form of salicylic acid, with two fluorine atoms replacing the 0-acetyl group on the carbon 4 position of aspirin. Diflunisal does not break down into salicylic acid in the body.
How Dolobid works in the bodyWe don't know exactly how diflunisal works, but it's thought to be related to its ability to reduce the amount of pain-causing and inflammation-causing molecules in the body. Diflunisal is a prostaglandin synthetase inhibitor, meaning it stops pain-causing and inflammation-causing molecules from forming. By decreasing the amount of these molecules, diflunisal helps reduce pain and inflammation.

When to interrupt dosage

The endorsed dosage of Dolobid is subject to the specified condition, such as Rheumatoid Arthritis, Mild pain and Pain. The measure of dosage wavers, in relation to the technique of delivery (e.g. Tablet - Oral or Oral) displayed in the table underneath.
Condition
Dosage
Administration
Mild pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Pain
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Rheumatoid Arthritis
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral
Osteoarthritis
500.0 mg, , 250.0 mg
, Tablet, film coated, Oral, Tablet, film coated - Oral, Tablet, Tablet - Oral

Warnings

There are 20 known major drug interactions with Dolobid.
Common Dolobid Drug Interactions
Drug Name
Risk Level
Description
Enasidenib
Major
The metabolism of Enasidenib can be decreased when combined with Diflunisal.
Macimorelin
Major
The therapeutic efficacy of Macimorelin can be decreased when used in combination with Diflunisal.
Methotrexate
Major
The serum concentration of Methotrexate can be increased when it is combined with Diflunisal.
Mifamurtide
Major
The therapeutic efficacy of Mifamurtide can be decreased when used in combination with Diflunisal.
Mycophenolic acid
Major
The metabolism of Mycophenolic acid can be decreased when combined with Diflunisal.
Dolobid Toxicity & Overdose RiskThe toxic dose of diflunisal in rats, mice, and rabbits is 392mg/kg, 439mg/kg, and 603mg/kg, respectively. Overdosing on diflunisal can cause drowsiness, nausea, vomiting, diarrhea, rapid breathing, fast heartbeat, sweating, ringing in the ears, confusion, stupor, and coma. The smallest amount of diflunisal that has led to death is 15 grams. Taking diflunisal can increase the risk of serious heart problems such as heart attack and stroke in some patients. It can also cause ulcers
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Dolobid Novel Uses: Which Conditions Have a Clinical Trial Featuring Dolobid?

75 active clinical trials are being carried out to explore the potential of Dolobid for alleviating Osteoarthritis (OA), Mild pain and Rheumatoid Arthritis.
Condition
Clinical Trials
Trial Phases
Rheumatoid Arthritis
53 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2, Phase 1
Pain
0 Actively Recruiting
Osteoarthritis
0 Actively Recruiting
Mild pain
0 Actively Recruiting

Dolobid Reviews: What are patients saying about Dolobid?

5Patient Review
4/21/2008
Dolobid for Joint Damage causing Pain and Loss of Function
I've only been taking this for two weeks, but it has already alleviated the pain I experience in my lower back and hip area. As someone who works with their hands a lot, this has been huge. No side effects so far that I can tell, touch wood.
5Patient Review
8/9/2008
Dolobid for Arthritis
Out of all the NSAIDs I've tried, this one works best for me. It takes effect quickly, like aspirin, which is helpful when I need relief right away.
5Patient Review
3/27/2008
Dolobid for Rheumatoid Arthritis
The Nabumetone 750 mg. bothered my stomach, so I was given this at 500 mg. and it helped tremendously!
5Patient Review
11/27/2007
Dolobid for Pain
5Patient Review
3/26/2009
Dolobid for Rheumatoid Arthritis
As a nursing student, I found this medication to be very informative and helpful.
4.7Patient Review
5/28/2008
Dolobid for Arthritis
I stay away from NSAIDs because of FDA warnings.
4.3Patient Review
4/10/2014
Dolobid for Headache caused by Disorder of Cranial Blood Vessels
Even when taken with food or milk, this medication was very harsh on my stomach. I didn't find it to be any more effective than over-the-counter ibuprofen.
4Patient Review
12/6/2015
Dolobid for Joint Damage causing Pain and Loss of Function
Long-term or full seasonal use of Dolobid doesn't seem to result in any side effects, from what I can tell. Fioricet combined with Fexofenadine Hcl works well for migraines that are due to CBV during seasonal allergies--I've been using this method since 1995. When I visited the Philippines for a year and didn't have access to Fioricet, Diflunisal 500 mg worked well as a stopgap measure but it wasn't ideal.
4Patient Review
2/14/2011
Dolobid for Rheumatoid Arthritis
This treatment helped with my swelling and bloating.
2.3Patient Review
3/2/2014
Dolobid for Arthritis
I find this medication helpful in terms of falling asleep; however, I often wake up during the night and have difficulty returning to sleep.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about dolobid

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is DOLOBID used for?

"Diflunisal is taken to help with mild to moderate pain that is caused by various conditions. Additionally, it can help reduce pain, swelling, and joint stiffness that is caused by arthritis. By reducing these symptoms, it becomes easier to do normal daily activities. This medication is classified as a nonsteroidal anti-inflammatory drug (NSAID)."

Answered by AI

Is DOLOBID same as ibuprofen?

"A study found that DOLOBID is just as effective as aspirin. The study was double-blind and lasted for 12 weeks, during which patients took different dosages of either DOLOBID or ibuprofen. The results showed that both drugs were effective and had a similar tolerability."

Answered by AI

Is DOLOBID discontinued?

"was a medication used to relieve pain and inflammation.

Dolobid was a medication used to relieve pain and inflammation, but it is no longer available in the U.S."

Answered by AI

Is DOLOBID a narcotic?

"DOLOBID is a non-steroidal drug that can be used to relieve pain, inflammation, and fever. It is a peripherally-acting non-narcotic analgesic drug."

Answered by AI

Clinical Trials for Dolobid

Image of Sunnybrook Health Sciences Centre in Toronto, Canada.

Steroids for Rheumatoid Arthritis

18+
All Sexes
Toronto, Canada
People living with rheumatoid arthritis (RA) often experience flares-periods where their symptoms suddenly get worse. These flares can cause significant pain, make it harder to move and do daily activities, and lower overall quality of life. Doctors often treat flares with medications called glucocorticoids (GCs), which reduce inflammation. These medications can be taken by mouth (oral/PO) or given as a single injection into the muscle (intramuscular/IM). However, it's not clear which option works better from the patient's point of view-especially when it comes to relief of symptoms, improvements in function, and satisfaction with treatment. Most research so far has focused on how well the drugs control the disease, rather than how they impact the patient's overall experience. Our Research Questions: 1. Does a single GC injection work just as well as taking pills over a few weeks in improving symptoms reported by patients? 2. How do the two treatments compare in terms of symptom relief, ability to function, and patient satisfaction? 3. What do patients think and feel about using GCs to treat RA flares? What We Think: We believe that a one-time GC injection is just as good as taking pills for a few weeks when it comes to managing RA flares. In fact, the injection might even be safer and preferred by patients. What We're Doing: We will study 220 adults with RA who are currently having a flare (with at least 3 swollen and tender joints). These patients will be recruited from rheumatology clinics at the University of Toronto and must not have used GCs in the past month. They will be randomly assigned to receive either: A single injection (Methylprednisolone 120 mg), or Oral pills (Prednisone starting at 15 mg daily and tapering down over 3 weeks). The main thing we'll look at is how much better patients feel after 6 weeks, based on a questionnaire designed to measure RA flares. We'll also look at how well they function, how satisfied they are with the treatment, and whether they had any side effects. In addition, 20 patients (10 from each group) will be interviewed to understand their experiences and opinions about flare treatment in more detail. Why This Is Possible: We've already surveyed University of Toronto rheumatologists who support the idea and provided input on study design. We've also partnered with experts in research methods, national arthritis organizations, and patient groups to make sure the study is relevant and meaningful. Ethics approval has been obtained. Why It Matters: RA flares can have a major impact on people's lives. While current treatments help control inflammation, we need to better understand how these treatments affect people from their own perspective. This study will shift the focus to what matters most to patients, helping doctors and patients choose the best treatment based not only on medical results but also on the patient's experience. This could lead to more effective and personalized care for people living with RA.
Phase 4
Waitlist Available
Sunnybrook Health Sciences Centre (+4 Sites)
Image of California Clinical Trials Medical Group in Glendale, United States.

NTR-1011 for Lupus and Rheumatoid Arthritis

18 - 75
All Sexes
Glendale, CA
This phase 1a and 1b study is designed to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, immunogenicity, and preliminary efficacy of NTR-1011 in healthy adults and in adult patients with systemic lupus erythematosus and rheumatoid arthritis. The main goals of this study are to determine the safety profile of NTR-1011 across subcutaneous and intravenous dose levels, understand how the drug behaves in the body, characterize its biological activity through relevant pharmacodynamic markers, assess the potential for immune responses to treatment, and explore early signals of clinical benefit in autoimmune disease settings. This is a randomized, double blind, placebo controlled study that begins with a single ascending dose evaluation in healthy volunteers followed by a multiple dose assessment in patients. The design is intended to define the highest safe and well tolerated dose, establish a robust PK and PD baseline, and generate initial patient level evidence to support dose selection and advancement into subsequent clinical development.
Phase 1
Recruiting
California Clinical Trials Medical GroupHakop Gevorkyan, MDNeutrolis
Image of Weill Cornell Medical College in New York, United States.

Health Coaching for Rheumatoid Arthritis

18+
All Sexes
New York, NY
The goal of this clinical trial is to learn if peer coaching works to reduce levels of anxiety and/or depression in adults diagnosed with Rheumatoid Arthritis (RA). The main questions it aims to answer are: Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months from baseline? Do people with RA who complete the intervention with a peer coach have lower levels of anxiety and/or depression at 6 months compared to those in the control arm? Researchers will compare the peer coaching intervention to an active-control arm (where people without RA coach participants on general health and nutrition topics) to see if peer coaching works to reduce anxiety and/or depression. Participants will meet with a coach every week for 9 weeks and complete several surveys before, during and after the intervention
Recruiting
Has No Placebo
Weill Cornell Medical CollegeIris Y Navarro-Millán, MDBristol-Myers Squibb
Image of Humana Healthcare Research, Inc. in Louisville, United States.

Academic Detailing for Rheumatoid Arthritis

Any Age
All Sexes
Louisville, KY
The goal of this trial is to learn if an interactive evidence-based educational outreach visits to clinicians who prescribe biologics change prescribing of biosimilar medications. The main questions it aims to answer are: 1. Do educational outreach visits lead to a higher number of prescriptions for biosimilar versions of adalimumab? 2. Do in-person or virtual visits work better? Researchers will compare clinicians offered the educational outreach visit to those who are not offered the visit to see if there is a difference in prescribing of biosimilar versions of adalimumab instead of the original brand-name version. Participants will be offered the chance to meet with a trained clinician who will provide educational information tailored to their knowledge and attitudes on the topic. They will also be provided an educational brochure and patient educational materials.
Waitlist Available
Has No Placebo
Humana Healthcare Research, Inc. (+1 Sites)
Have you considered Dolobid clinical trials? We made a collection of clinical trials featuring Dolobid, we think they might fit your search criteria.Go to Trials
Image of University of Minnesota Medical School, Division of Rheumatic and Autoimmune Diseases in Minneapolis, United States.

Ultrasound Therapy for Rheumatoid Arthritis

18+
All Sexes
Minneapolis, MN
The At-Home ULTRA Study will evaluate performance of the MINI system as indicated for the treatment of adults with active, moderate to severe rheumatoid arthritis who are inadequate responders or are intolerant to conventional synthetic disease-modifying anti-rheumatic drugs (csDMARDs), biologic DMARDs (bDMARDs), or targeted synthetic DMARDs (tsDMARDs). The non-invasive study device delivers ultrasound stimulation to the spleen to reduce inflammation. The study will enroll at least 60 participants at up to 8 sites. There will be three arms consisting of two active stimulation groups (treatment) and one non-active stimulation group (sham-control). After completing the double-blinded primary endpoint assessment period at Week 12, there will be a one-way crossover of control participants to active stimulation and an additional 12 week follow-up with all participants to evaluate long-term outcomes.
Recruiting
Drug
University of Minnesota Medical School, Division of Rheumatic and Autoimmune DiseasesHubert LimSecondWave Systems Inc.
Image of St. Lawrence Health in Potsdam, United States.

Primary Care for Rheumatoid Arthritis

18+
All Sexes
Potsdam, NY
Rheumatoid arthritis (RA) is a complex autoimmune disease where the immune system attacks healthy joint tissue; causing pain, swelling, and stiffness of the joints. This disease effects lots of people in the US and can lead to major joint damage if not properly treated. In rural areas like northern NY, these are underserved areas for RA patients, thus many patients struggle to get the appropriate care. This model is testing whether primary care providers (PCP) can safely and effectively provide stable RA patients with the proper treatment rather than send them to a specialist. PCPs were trained through classes, case reviews, and a final exam. Patients will be randomly assigned to either see a trained PCP or their normal rheumatologist at the rheumatology clinic. This study will examine how patients are doing over a year using medical exams and patient feedback. If this model proves to be successful, it will make RA treatment easier and more affordable for patients.
Recruiting
Has No Placebo
St. Lawrence HealthEyal Kedar, MD
Have you considered Dolobid clinical trials? We made a collection of clinical trials featuring Dolobid, we think they might fit your search criteria.Go to Trials
Image of Clinical Research Of West Florida - Phase I Unit /ID# 272428 in Clearwater, United States.

Targeted Therapies for Rheumatoid Arthritis

18+
All Sexes
Clearwater, FL
Rheumatoid Arthritis (RA) is a chronic inflammatory disease causing pain, stiffness, swelling and loss of joint function. This study will evaluate the efficacy and safety of targeted therapies through a series of substudies for the treatment of moderately to severely active Rheumatoid Arthritis (RA). This study currently includes 3 substudies evaluating different treatments in participants with RA. Substudy 1 will evaluate lutikizumab monotherapy (treatment given alone) compared to placebo (looks like the study treatment but contains no medicine). Substudy 2 will evaluate ravagalimab monotherapy compared to placebo and Substudy 3 will evaluate lutikizumab and ravagalimab combination therapy (treatments given together) compared to placebo. Approximately 180 participants who have failed 1 or 2 biologic/targeted synthetic disease-modifying antirheumatic drug (tsDMARD) therapies will be enrolled in the study at approximately 65 sites worldwide. There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires.
Phase 2
Recruiting
Clinical Research Of West Florida - Phase I Unit /ID# 272428 (+31 Sites)ABBVIE INC.AbbVie
Have you considered Dolobid clinical trials? We made a collection of clinical trials featuring Dolobid, we think they might fit your search criteria.Go to Trials
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