SPY072 for Rheumatoid Arthritis
(SKYWAY-RD Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment called SPY072, an experimental therapy, to determine its effectiveness for certain types of arthritis, including rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis. The study aims to assess both the efficacy and safety of SPY072. Participants will be divided into groups to receive either the treatment or a placebo, which contains no active medication. Individuals diagnosed with any of these types of arthritis who continue to experience symptoms despite other medications may find this trial suitable. As a Phase 2 trial, this research focuses on evaluating the treatment's effectiveness in an initial, smaller group of participants.
Do I need to stop my current medications for the trial?
The trial information does not specify if you need to stop your current medications. However, it mentions that participants should have an inadequate response to certain treatments, which might imply continuing some medications. Please consult with the trial coordinators for specific guidance.
Is there any evidence suggesting that SPY072 is likely to be safe for humans?
Earlier studies found that single doses of SPY072 up to 1500 mg were well-tolerated, with no serious side effects reported. The safety profile of SPY072 aligns with similar treatments, indicating it is generally safe. Tests on various groups, including those with rheumatoid arthritis, axial spondyloarthritis, and psoriatic arthritis, provided this information. These results offer promise for treating rheumatic diseases, but further research is necessary to confirm its long-term safety.12345
Why do researchers think this study treatment might be promising for rheumatoid arthritis?
Researchers are excited about SPY072 because it's a promising new approach for treating rheumatoid arthritis. Unlike traditional treatments like methotrexate or TNF inhibitors, which mainly suppress the immune system to reduce inflammation, SPY072 targets specific pathways that may offer more precise control of the disease. This targeted mechanism could potentially lead to fewer side effects and improved effectiveness. Additionally, SPY072's formulation might allow for more convenient dosing, providing patients with a simpler and more manageable treatment option.
What evidence suggests that this trial's treatments could be effective?
Studies have shown that SPY072, a medication targeting a protein involved in inflammation, is well tolerated and shows promise in treating several joint-related conditions. Research indicates that SPY072 effectively interacts with this protein for up to 20 weeks, suggesting it might help reduce symptoms in conditions like rheumatoid arthritis, psoriatic arthritis, and axial spondyloarthritis. In this trial, participants with rheumatoid arthritis will receive one of two dosing regimens of SPY072, while others will receive it for psoriatic arthritis or axial spondyloarthritis. The treatment's movement through the body supports less frequent dosing, which could be more convenient for patients. Initial findings from earlier trials highlighted its potential in managing inflammation and improving patient outcomes.16789
Who Is on the Research Team?
SKYWAY-RD Study Director
Principal Investigator
Spyre Therapeutics
Are You a Good Fit for This Trial?
Adults aged 18 or older with rheumatic diseases such as Psoriatic Arthritis, Rheumatoid Arthritis, Ankylosing Spondylitis, or Axial Spondyloarthritis can join this study. Specific eligibility criteria are not provided but typically include a confirmed diagnosis and stable condition.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive double-blind dosing regimen of SPY072 or placebo
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- SPY072
Find a Clinic Near You
Who Is Running the Clinical Trial?
Spyre Therapeutics, Inc.
Lead Sponsor