Assertive Outreach for Emergencies

Phase-Based Estimates
3
Effectiveness
3
Safety
The University of Texas Health Science Center at Houston, Houston, TX
Emergencies+9 More
Assertive Outreach - Behavioral
Eligibility
< 18
All Sexes
Eligible conditions
Emergencies

Study Summary

This study is evaluating whether a community-based program can help reduce opioid overdoses and opioid use disorder among young people.

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Eligible Conditions

  • Emergencies
  • Disease
  • Opiate Overdose
  • Drug Abuse
  • Opioid Abuse
  • Opioid Overdose
  • Opioids Use
  • Substance Use Disorders (SUD)
  • Opioid Use Disorder (OUD)
  • Opioid Dependence
  • Substance-Related Disorders
  • Opioid-Related Disorders

Treatment Effectiveness

Effectiveness Estimate

3 of 3
This is better than 93% of similar trials

Study Objectives

This trial is evaluating whether Assertive Outreach will improve 2 primary outcomes and 1 secondary outcome in patients with Emergencies. Measurement will happen over the course of 30 days after enrollment.

30 days after enrollment
Patient abstinence from opioids
Patient retention in treatment
Year 3
Frequency of opioid emergencies among adolescents in Houston, Texas

Trial Safety

Safety Estimate

3 of 3
This is better than 85% of similar trials

Trial Design

2 Treatment Groups

Control
MOUD induction and behavioral interventions among opioid-dependent youths

This trial requires 15 total participants across 2 different treatment groups

This trial involves 2 different treatments. Assertive Outreach is the primary treatment being studied. Participants will all receive the same treatment. There is no placebo group. The treatments being tested are in Phase 4 and have been shown to be safe and effective in humans.

MOUD induction and behavioral interventions among opioid-dependent youthsInduction into medication for opioid use disorder (MOUD) treatment and behavioral interventions
ControlNo treatment in the control group
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Support Group
2016
N/A
~370
Individual Counseling
2006
Completed Phase 3
~400

Trial Logistics

Trial Timeline

Approximate Timeline
Screening: ~3 weeks
Treatment: Varies
Reporting: through study completion, an average of 3 years
This trial has the following approximate timeline: 3 weeks for initial screening, variable treatment timelines, and roughly through study completion, an average of 3 years for reporting.

Who is running the study

Principal Investigator
J. L.
Prof. James Langabeer, Professor
The University of Texas Health Science Center, Houston

Closest Location

The University of Texas Health Science Center at Houston - Houston, TX

Eligibility Criteria

This trial is for patients born any sex aged 18 and younger. You must have received 1 prior treatment for Emergencies or one of the other 9 conditions listed above. There are 6 eligibility criteria to participate in this trial as listed below.

Mark “yes” if the following statements are true for you:
The person is in good health, based on what the doctor has seen and what they know of their medical history. show original
The person's drug screen came back positive for opioids. show original
Patients report that they are willing to stop using opioids if they could find an alternative way to manage their pain. show original
Meet Diagnostic and Statistical Manual of Mental Disorders - Text Revision (DSM-IV-TR) criteria for opioid dependence
to be eligible for the study show original
form The test subject must be agreeable to and capable of signing the informed consent and assent form show original

Patient Q&A Section

Please Note: These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Who should consider clinical trials for emergencies?

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For certain conditions, there is evidence that clinical trials are of benefit both in terms of reduced death and reduced illness. This does not appear to be true of emergency care, where evidence appears in favour of caution.

Unverified Answer

Can emergencies be cured?

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[There were not enough data at the regional level for one place to be able to generalize these results to another area] at the current time. [Further studies are needed in the different communities to validate the results.

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What is emergencies?

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This is a concise explanation of the nature, causes, and treatment of the various urgent medical conditions encountered by the general practitioner. It will be invaluable in facilitating accurate and relevant thinking while the practitioner is answering patients' questions. As such a description will help to avoid unnecessary anxiety and potentially costly investigations for both doctor-patient and patient-patient interactions.

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What causes emergencies?

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The majority of emergency departments in England were crowded, but this was predominantly because of a higher-than-average proportion of non-English patients. Emergency departments are staffed by inexperienced doctors and nurses, who are unprepared for this proportion of non-English patients, and a high proportion of foreign patients. We recommend further training for all junior staff and more formal links between specialist emergency departments and other services.

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How many people get emergencies a year in the United States?

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Every year, millions of Americans experience emergencies. These emergencies include a wide variety of illnesses, injuries, and illnesses with medical emergencies of all types. Overall the number of Americans experiencing an emergency increases with age. In emergency situations, people over 65 years old are 2-3 times more likely to have an emergency than their younger counterparts. The most frequent emergency types include respiratory, gastrointestinal, musculoskeletal and cardiovascular disorders. All of which contribute to a large portion of the total number of emergencies experienced in a year.

Unverified Answer

What are common treatments for emergencies?

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The greatest number of patients at risk of an emergency encountered in this survey consisted of those between the ages of 20 and 40; although more than half (59%) of patients with diabetes mellitus and 20 days or more of disease duration, and only 12% of patients with less than 6 days of the disease contemplated the possibility of an emergency. Patients who were older, male, and had less than 6 days of the disease anticipated an emergency.

Unverified Answer

What are the signs of emergencies?

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There are a variety of emergency signs reported in medical literature and patient experience. The most reliable signs reported in the literature are the three B sign (pain, blood and bulging of umbilicus), the six C sign (chest pain, caval distension, cyanosis, currant jelly appearance in eye, cold extremities) and the Huddleson triad (hemiparesis, pain, and paresthesia). Only three signs (hemiparesis, cold extremities and paresthesia) met the criteria for a high level of agreement in our study. One major sign, pulsus paradoxus may also be used to predict other signs and thus could be helpful in the early diagnosis of some conditions.

Unverified Answer

Have there been any new discoveries for treating emergencies?

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A new treatment for stroke has been developed in Brazil. For many years, there have been many studies in developing countries on cancer, but research on other diseases of the body is very rare. Also, many treatment protocols are only used in developed countries. There are few guidelines for emergency treatment. As the global crisis for treating Emergencies (see the epidemiology section) worsens and the demand for these drugs for treatment increases, the use of foreign drugs is very likely to increase. Many of these new drugs were originally discovered at foreign institutions, and therefore the prices are lower in [developing countries such as Brazil] than in [well-researched countries such as the United States] and the patients could potentially get [these drugs cheaper].

Unverified Answer

What is the average age someone gets emergencies?

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It was found that emergencies were experienced from as early as 10 years and the average age was 20 years. Some parents were anxious that their children were experiencing emergencies. Results from a recent paper imply that the age of a patient should be a crucial fact when looking out for and addressing emergencies. If a patient is experiencing an emended course, health professionals should consider this before deciding on treatment and, if necessary, ensure that the patient's medical records are accurate and up-to-date.

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What is the primary cause of emergencies?

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Primary causes of ED presentations including trauma are rare. Patients are rarely resuscitated from cardiovascular arrest and less frequently acutely ill or seriously unwell. Patients with high levels of consciousness frequently present to the emergency department with unevaluable complaints.

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Is assertive outreach typically used in combination with any other treatments?

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In this large sample of acute outpatient cases treated with AOD in Australia, the use of AOD generally coincided with use of additional therapies and was generally associated with a better outcome.

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What does assertive outreach usually treat?

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Most cases in our city present with multiple underlying conditions, which may have contributed to their poor progress. Identifying their problems early and establishing a workable treatment plan is crucial in order to provide the best outcomes for this vulnerable population.

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