Antibiotics for Facial Reconstructive Surgery
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you have used systemic antibiotics within one week before surgery.
What data supports the effectiveness of the drug cephalexin for facial reconstructive surgery?
Cephalexin is effective in treating skin and soft-tissue infections, achieving cure rates of 90% or higher, which suggests it could be beneficial in preventing infections after facial reconstructive surgery. Additionally, in a study on endoscopic skull base surgery, a regimen including cephalexin showed low rates of postoperative infections, supporting its use in surgical settings.12345
Is cephalexin safe for use in humans?
How does the drug used in the clinical trial for facial reconstructive surgery differ from other treatments?
What is the purpose of this trial?
Antibiotics are sometimes prescribed to patients who have had reconstructive surgery of wounds on their face using skin grafts. But, it is not yet known whether antibiotics improve the healing of skin grafts and reduce the risk of infections after surgery in these patients. It is known that antibiotics, like all medications, have side-effects although these are rare. This research study is designed to show us whether antibiotics improve wound healing or not, so that we may determine if we should continue using antibiotics even if they have side-effects in some patients.Our hypothesis is that patients treated with post-operative, systemic antibiotics will demonstrate a statistically significant improvement in the survival of their facial full thickness skin grafts compared to patients who are not treated with systemic antibiotics.
Research Team
Jeffrey Y Moyer, MD
Principal Investigator
University of Michigan Otolaryngology
Eligibility Criteria
This trial is for adults needing facial reconstruction with a full-thickness skin graft, without current or recent antibiotic use, no intolerance to clindamycin and cephalexin, and no previous reconstruction at the defect site.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive peri-operative antibiotics and, for some, post-operative antibiotics to assess their impact on skin graft survival
Follow-up
Participants are monitored for graft survival and any post-operative complications
Treatment Details
Interventions
- Cephalexin
Find a Clinic Near You
Who Is Running the Clinical Trial?
University of Michigan
Lead Sponsor