300 Participants Needed

Auditory Interventions for Stuttering

Recruiting at 1 trial location
AD
Overseen ByAyoub Daliri, PhD
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: Arizona State University
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial explores new methods to help people who stutter improve their communication skills and quality of life. It tests various auditory and brain-based techniques, such as adjusting how sounds are heard before speaking or slightly delaying speech, to assess their effects on reducing stuttering. Participants will engage in tasks like naming pictures, reading, and listening to various sounds while researchers monitor speech and brain activity. The trial seeks monolingual native American English speakers who stutter but have no other developmental or communication disorders.

As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could lead to new therapies for stuttering.

Will I have to stop taking my current medications?

If you are taking any medications that affect the central nervous system, you will need to stop taking them to participate in this trial.

What prior data suggests that these auditory interventions are safe for stuttering?

Research has shown that delayed auditory feedback (DAF), used in this trial, is generally safe. Studies have found that DAF can reduce stuttering by 60% to 80%. However, it might cause some speech mistakes or slow down speaking in people who do not stutter. For those who do stutter, DAF usually helps stabilize speech.

Specific information on the safety of delaying speech start is limited, but DAF, which is similar, is commonly used in speech therapy and is not regulated by the FDA. This suggests it is generally accepted and safe to use.

Neither method is known to cause significant harm. Participants might notice changes in how they speak or hear themselves, but these are expected and not dangerous. Always discuss any concerns with the study team before joining.12345

Why are researchers excited about this trial?

Researchers are excited about these auditory interventions for stuttering because they explore innovative approaches that differ from traditional speech therapy and pharmacological treatments. One unique feature is the focus on pre-speech auditory modulation, which aims to adjust auditory perception before speaking to improve fluency. Another distinctive approach is delaying auditory feedback, where the timing of hearing one's own voice is altered, potentially reducing stuttering by disrupting the typical speech pattern. By targeting the speech premotor cortex and experimenting with delayed speech initiation, these methods offer new insights into brain-speech dynamics, providing a fresh perspective on stuttering management.

What evidence suggests that this trial's treatments could be effective for stuttering?

Research has shown that delayed auditory feedback, one of the interventions in this trial, can greatly help people who stutter. It can reduce stuttering by 60% to 80%, making speech smoother. This method is especially beneficial for those with severe stuttering. Another intervention in this trial involves starting to speak a little later, often used alongside delayed auditory feedback, and has also effectively reduced speech problems. These techniques, part of different treatment arms in this trial, alter the timing of speaking and hearing, improving speech flow for people who stutter.56789

Are You a Good Fit for This Trial?

This trial is for monolingual, native American English speakers who stutter but don't have other developmental, psychological, neurological disorders. They must have normal hearing and not be on central nervous system medications. Adults can't have conditions that make brain stimulation or MRI unsafe.

Inclusion Criteria

My hearing is normal for my age.
I have no health issues preventing me from undergoing tDCS, TMS, or MRI.
I am not on any medications that affect my brain or nerves.
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Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in tasks such as naming pictures, reading words/sentences, and listening to speech and nonspeech sounds while their speech, muscle, and brain signals are collected. Some participants may also receive brain stimulation.

Each session may last up to 2 hours

Follow-up

Participants are monitored for changes in speech and brain activity in response to auditory errors and speech tasks.

4 weeks

What Are the Treatments Tested in This Trial?

Interventions

  • Auditory errors and pre-speech auditory modulation
  • Contributions of the speech premotor cortex to pre-speech auditory modulation
  • Delaying auditory feedback
  • Delaying speech initiation
Trial Overview The study tests how individuals who stutter predict and process auditory errors before speaking. It involves naming pictures, reading silently or aloud, listening to sounds while monitoring speech, muscle, and brain signals. Some may get brain stimulation during these tasks.
How Is the Trial Designed?
4Treatment groups
Experimental Treatment
Group I: Group 4Experimental Treatment1 Intervention
Group II: Group 3Experimental Treatment1 Intervention
Group III: Group 2Experimental Treatment1 Intervention
Group IV: Group 1Experimental Treatment1 Intervention

Find a Clinic Near You

Who Is Running the Clinical Trial?

Arizona State University

Lead Sponsor

Trials
311
Recruited
109,000+

University of Washington

Collaborator

Trials
1,858
Recruited
2,023,000+

National Institute on Deafness and Other Communication Disorders (NIDCD)

Collaborator

Trials
377
Recruited
190,000+

Published Research Related to This Trial

A study involving 12 stuttering and 12 nonstuttering adults found that nonstuttering individuals showed a significant reduction in N1 amplitude during speech planning, indicating effective modulation of auditory processing.
In contrast, the stuttering group did not exhibit this modulation, suggesting that deficiencies in auditory system integration during speech planning may contribute to the speech dysfluencies seen in stuttering.
Modulation of auditory processing during speech movement planning is limited in adults who stutter.Daliri, A., Max, L.[2018]
The study identified a significant auditory error signal in the auditory cortex when participants experienced delayed auditory feedback, which disrupted their speech fluency, indicating how the brain detects and corrects vocalization errors in real time.
Additionally, the dorsal precentral gyrus (dPreCG) showed a similar response enhancement during speech production, particularly for longer utterances, suggesting it plays a crucial role in processing auditory feedback to maintain fluent speech.
A cortical network processes auditory error signals during human speech production to maintain fluency.Ozker, M., Doyle, W., Devinsky, O., et al.[2022]
Delayed auditory feedback (DAF) significantly improved speech fluency in individuals who stutter without central auditory processing disorders, reducing stuttering-like disfluencies and repetitions.
In contrast, DAF did not show a significant effect on fluency for individuals who stutter and also have central auditory processing disorders, indicating that auditory processing issues may limit the effectiveness of this intervention.
Effect of delayed auditory feedback on stuttering with and without central auditory processing disorders.Picoloto, LA., Cardoso, ACV., Cerqueira, AV., et al.[2022]

Citations

1.pubmed.ncbi.nlm.nih.govpubmed.ncbi.nlm.nih.gov/39977721/
Effect of delayed auditory feedback on stuttering-like ...What is already known on the subject Delayed auditory feedback (DAF) has been shown to reduce stuttering frequency by between 60% and 80%.
Impact of auditory feedback alterations in individuals with ...The effect of delayed auditory feedback was favorable for the Severe Stuttering Group, promoting speech fluency.
Delayed auditory feedback increases speech production ...Delayed auditory feedback increases speech production variability in typically fluent adults but has the opposite effect in stuttering adults · Method · Results.
(PDF) Systematic review of delayed auditory feedback ...To perform a systematic review of studies related to the effects of delayed auditory feedback on speech fluency in individuals who stutter.
Deficit or Difference? Effects of Altered Auditory Feedback ...The purpose of this study was to test whether adults who stutter (AWS) display a different range of sensitivity to delayed auditory feedback (DAF).
Effects of delayed auditory feedback and frequency-shifted ...It “is an operant treatment that incorporates parental verbal contingencies for stuttered speech and stutter-free speech. The contingencies for stutter-free ...
Effect of delayed auditory feedback on stuttering-like ...What is already known on the subject Delayed auditory feedback (DAF) has been shown to reduce stuttering frequency by between 60% and 80%.
Subtle Patterns of Altered Responsiveness to Delayed ...Delayed auditory feedback (DAF) introduces timing discrepancies between perception and action, disrupting sequence production in verbal and non-verbal domains.
Can Typically Fluent Adults Adapt to Long-Latency ...Delayed auditory feedback (DAF) is a potent speech perturbation that can induce disfluencies and speech errors along with slowing speaking rate in typical ...
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