Diagnostic Imaging for Coronary Heart Disease
(SWAN Trial)
Trial Summary
Will I have to stop taking my current medications?
The trial does not specify if you need to stop taking your current medications, but you cannot participate if you are using a vasospastic agent (a medication that can cause blood vessels to spasm).
What data supports the effectiveness of the treatment Intravascular ultrasound, MRI, Magnetic Resonance Imaging for Coronary Heart Disease?
MRI is a valuable tool for diagnosing coronary heart disease as it can detect heart damage, assess heart function, and visualize blood flow without using radiation. Intravascular MR imaging offers high-resolution images and can guide cardiovascular treatments, making it a promising method for managing heart disease.12345
Is diagnostic imaging for coronary heart disease, like MRI, safe for humans?
How is the treatment using intravascular ultrasound and MRI different from other treatments for coronary heart disease?
This treatment is unique because it uses intravascular MRI, which provides high-resolution images of the coronary arteries without exposing patients to radiation or requiring contrast agents. It allows for detailed assessment of plaque in the arteries and can guide interventions, offering a noninvasive and comprehensive approach to managing coronary heart disease.1351112
What is the purpose of this trial?
Approximately 600,000 women are treated for acute coronary syndrome (ACS) annually in the US. ACS includes heart attack and a milder form called unstable angina. Many of these women have angiograms of which 14-39% show no "significant" coronary artery disease (CAD, cholesterol plaque accumulation in arteries of the heart). The remaining majority of women with ACS have cholesterol plaque buildup which appears severe enough on angiography to limit blood flow to the heart.It is difficult to advise women with heart attacks and no major heart artery blockages on what to do if chest pain happens again. Additional studies are needed to find out why this sort of heart attack happens and to help doctors understand how to treat patients who have this problem in the best possible way.Some women with heart attacks who have no major blockage in heart arteries have cholesterol plaque in the arteries of the heart cannot be seen on angiography but can be seen using a newer technique called intravascular ultrasound (IVUS). IVUS involves creating pictures of the artery walls using ultrasound (sound waves) from within the artery itself. In some women without major heart artery blockage, heart attack is caused by low blood flow due to disease of smaller blood vessels which cannot be seen on angiography or IVUS. This problem can be found using magnetic resonance imaging (MRI), which can show blood flow to the heart. MRI may also be used to show where the heart has been damaged. The pattern of damage could suggest that a heart attack in a woman, who has no badly blocked heart arteries, happened for one (or more) of these reasons or another reason.The Study of Women with ACS and Non-obstructive CAD (SWAN) will use IVUS and MRI to help determine the reasons for heart attacks in women with no major blockages in heart arteries.
Research Team
Harmony Reynolds, M.D.
Principal Investigator
NYU Langone Health
Eligibility Criteria
This trial is for women who have had a heart attack or unstable angina and are scheduled for an angiography, but do not have major blockages in their heart arteries. Women with previous obstructive coronary artery disease, those who can't undergo IVUS or MRI procedures, or those using vasospastic agents cannot participate.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Diagnostic Imaging
Participants undergo IVUS and MRI to determine the reasons for heart attacks in women with no major blockages in heart arteries
Follow-up
Participants are monitored for safety and effectiveness after diagnostic imaging
Treatment Details
Interventions
- Intravascular ultrasound
- MRI
Find a Clinic Near You
Who Is Running the Clinical Trial?
NYU Langone Health
Lead Sponsor
Doris Duke Charitable Foundation
Collaborator