Protein Supplements for Protein Metabolism

(YPQ Trial)

Overseen By Daniel R. Moore, Ph.D.

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Daniel Moore

Must be taking: Monophasic oral contraceptives

Must not be taking: Multiphasic contraceptives, Hormonal IUDs

Disqualifiers: Tobacco, Illicit drugs, Vegan diet, others

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: 1

Duration: 8 hours

13 Participants Needed

What You Need to Know Before You Apply

What is the purpose of this trial?

This trial aims to compare how different protein supplements affect whole-body protein synthesis, the process by which the body makes and uses proteins. The study will examine collagen (collagen hydrolysate supplement), whey (whey protein isolate supplement), and yeast protein supplements to assess their potential to support health while offering a more sustainable alternative to animal-based proteins. It seeks healthy, recreationally active individuals who can easily incorporate protein supplements into their diets and do not have certain dietary restrictions or lifestyle habits like smoking. Participants will consume a test drink and provide breath and urine samples over eight hours for analysis.

As an unphased trial, this study provides a unique opportunity to advance scientific understanding of sustainable protein sources.

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it does require that female participants use a specific type of birth control pill (monophasic combined oral contraceptives with 21 active pills).

Is there any evidence suggesting that this trial's treatments are likely to be safe?

A previous study found collagen supplements to be safe, with no major side effects. They are generally safe for oral consumption in doses up to 10 grams per day for up to six months. Whey protein is also likely safe for most adults when used properly. Although high doses might cause issues like more frequent bowel movements, such occurrences are uncommon.

Research has shown that yeast protein is a high-quality protein. The European Food Safety Authority (EFSA) confirms its safety for use in food. However, it is important not to exceed the recommended amount.

Overall, these protein supplements are generally safe for most people when used as directed. ^{1 2 3 4 5}

Why are researchers excited about this trial?

Researchers are excited about these protein supplements because they each offer a unique approach to enhancing whole-body protein metabolism. The Collagen Hydrolysate Supplement is derived from collagen, which may improve skin, joint, and muscle health beyond just protein synthesis. The Whey Protein Isolate Supplement is a concentrated form of whey protein, known for its fast absorption and rich amino acid profile, potentially making it a top choice for muscle recovery. Meanwhile, the Yeast Protein Supplement is experimental and offers a plant-based protein alternative that could deliver benefits without lactose or animal byproducts, appealing to those with dietary restrictions. These supplements provide varied options that go beyond traditional protein sources, catering to different dietary needs and health goals.

What evidence suggests that this trial's treatments could be effective for protein metabolism?

This trial will compare the effects of different protein supplements on whole-body protein metabolism. Research has shown that collagen supplements, which participants in one arm of this trial will receive, can reduce joint pain in athletes and increase muscle strength. They also improve skin health by enhancing elasticity and reducing wrinkles. Another arm of this trial will test whey protein, which studies indicate can boost muscle strength and aid in gaining muscle while losing fat. It may also support heart health by managing cholesterol levels. Yeast protein, tested in a separate arm of this trial, is a newer option but has already shown potential in building muscle and strength, similar to whey. Overall, these proteins can help maintain healthy body protein levels and enhance physical performance. ^{5 6 7 8 9}

Are You a Good Fit for This Trial?

This trial is for adults interested in the study of protein metabolism, specifically how different types of dietary proteins affect their body's protein synthesis. Participants should be healthy with no major medical conditions that could interfere with the study.

Inclusion Criteria

Participants willing to abide by the compliance rules of this study

Healthy will be defined as screened by the PAR-Q+ and The Physical Activity Readiness Questionnaire

I am healthy, active, and exercise regularly.

Exclusion Criteria

Inability to adhere to any of the compliance rules judged by principal investigator (e.g. dairy protein or yeast allergy)

Self-reported regular tobacco use

Self-reported illicit drug use (e.g., growth hormone, testosterone, etc.)

Timeline for a Trial Participant

Screening

Participants are screened for eligibility to participate in the trial

1-2 weeks

Treatment

Participants consume test beverages composed of different protein sources, and their whole-body protein metabolism is determined over 8 hours using breath tests and urine sampling.

8 hours

1 visit (in-person)

Follow-up

Participants are monitored for any immediate effects post-treatment and data analysis is conducted.

1 week

What Are the Treatments Tested in This Trial?

Interventions

• Collagen Hydrolysate Supplement
• Whey Protein Isolate Supplement
• Yeast Protein Supplement

Trial Overview The trial is testing three supplements: Whey Protein Isolate (from milk), Collagen Hydrolysate (animal-based), and Yeast Protein (microbial-based) to see which supports whole body protein synthesis best using a 'breath test' and urine sampling methods.

How Is the Trial Designed?

Group I: Yeast Protein Supplement Experimental Treatment 1 Intervention

Participants will be consuming test beverage composed of yeast protein and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Group II: Collagen Hydrolysate Supplement Active Control 1 Intervention

Participants will be consuming test beverage composed of collagen protein and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Group III: Whey Protein Isolate Supplement Active Control 1 Intervention

Participants will be consuming test beverage composed of whey protein isolate and their whole-body protein metabolism will be determined over the subsequent 8 hours.

Who Is Running the Clinical Trial?

Daniel Moore

Lead Sponsor

Trials

3

Recruited

30+

Lesaffre International

Industry Sponsor

Trials

11

Recruited

1,500+

Citations

1. pubmed.ncbi.nlm.nih.gov pubmed.ncbi.nlm.nih.gov/18416885/

24-Week study on the use of collagen hydrolysate as a ... Conclusion: This was the first clinical trial of 24-weeks duration to show improvement of joint pain in athletes who were treated with the dietary supplement ...

2. orthopedicreviews.openmedicalpublishing.org orthopedicreviews.openmedicalpublishing.org/article/129086-the-effects-of-type-i-collagen-hydrolysate-supplementation-on-bones-muscles-and-joints-a-systematic-review

The Effects of Type I Collagen Hydrolysate ... (+) Collagen supplementation demonstrated effectiveness in almost all running and endurance outcomes, 0,8. POR Positive Outcome Rate, COL ...

3. sciencedirect.com sciencedirect.com/science/article/pii/S2405844023021680

Collagen supplementation in skin and orthopedic diseases Literature data have shown that hydrolyzed collagen supplementation promotes skin changes, such as decreased wrinkle formation; increased skin elasticity; ...

4. mdpi.com mdpi.com/2072-6643/16/19/3403

The Effects of Collagen Peptides as a Dietary Supplement ... The results showed significant improvements in the fat-free mass (FFM), bone mass (BM), isokinetic quadriceps strength (IQS), and sensory motor control (SMC) ...

5. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC8944283/

Evaluation of the Efficacy of a Hydrolyzed Collagen ... Improvements in skin moisturization, skin elasticity, and wrinkle depth were measured in the participants taking the hydrolyzed collagen after 28 days. In all ...

6. pmc.ncbi.nlm.nih.gov pmc.ncbi.nlm.nih.gov/articles/PMC11432272/

The Efficacy and Safety of CollaSel Pro® Hydrolyzed ... In most of the previous studies, oral collagen supplements showed very well tolerability and no adverse effects [15,23]. In another clinical ...

7. webmd.com webmd.com/vitamins/ai/ingredientmono-1606/collagen-peptides

Collagen Peptides - Uses, Side Effects, and More When taken by mouth: Collagen peptides are possibly safe. Collagen peptides have been safely used in doses up to 10 grams daily for up to 6 months. Side effects ...

8. sciencedirect.com sciencedirect.com/science/article/pii/S2405844024124644

Hydrolyzed collagen: Exploring its applications in the food ... Hydrolyzed collagen is prepared from a denatured protein to be more easily absorbed and digested in the human body [13]. 3. Hydrolyzed collagen.

9. vinmec.com vinmec.com/eng/blog/is-taking-collagen-harmful-to-the-kidneys-and-stomach-en

Is taking collagen harmful to the kidneys and stomach? Therefore, a high-protein diet (>1.2g/kg/day) or even supplementing extremely high doses of hydrolyzed collagen does not harm the kidneys in ...