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PRP for Diminished Ovarian Reserve (PRP4POA Trial)

N/A
Recruiting
Led By David H Barad, MD
Research Sponsored by Center for Human Reproduction
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 44 years and under
Age 44 years and under.
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 8 weeks
Awards & highlights

PRP4POA Trial Summary

This trial will test whether Platelet Rich Plasma (PRP) can improve ovarian reserve in women with poor ovarian reserve. Women will be randomly assigned to treatment with either PRP or Platelet Poor Plasma (PPP).

Who is the study for?
Women under 45 with poor ovarian reserve, who haven't taken Aspirin or Motrin for a week, want to get pregnant through IVF, have had fewer than 6 eggs from past treatments, and have specific hormone levels (FSH > 12 and AMH < 1.0). It's not for those over age 45 or with certain blood diseases, clotting disorders, cancer, infections like sepsis, or autoimmune conditions.Check my eligibility
What is being tested?
The trial is testing the effects of injecting either Platelet Rich Plasma (PRP) or Platelet Poor Plasma (PPP) directly into the ovaries of women with diminished ovarian reserve to see if it can improve their fertility outcomes in IVF treatment.See study design
What are the potential side effects?
While specific side effects are not listed here, PRP and PPP procedures may include risks such as bleeding at the injection site, infection risk due to needle insertion into the body tissue and possible allergic reactions.

PRP4POA Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am 44 years old or younger.
Select...
I am 44 years old or younger.

PRP4POA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Embryo Transfer
Secondary outcome measures
AMH
Antral Follicle Count
Embryos Produced
Other outcome measures
Pregnancy

PRP4POA Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: PRP groupExperimental Treatment1 Intervention
Platelet RICH Plasma prepared using RegenLab FDA approved device.
Group II: PPP groupPlacebo Group1 Intervention
Platelet POOR Plasma prepared using RegenLab FDA approved device.

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor
13 Previous Clinical Trials
1,077 Total Patients Enrolled
David H Barad, MDPrincipal InvestigatorCenter for Human Reproduction
1 Previous Clinical Trials
30 Total Patients Enrolled

Media Library

PPP - Platelet Poor Plasma (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04278313 — N/A
Diminished Ovarian Reserve Research Study Groups: PPP group, PRP group
Diminished Ovarian Reserve Clinical Trial 2023: PPP - Platelet Poor Plasma Highlights & Side Effects. Trial Name: NCT04278313 — N/A
PPP - Platelet Poor Plasma (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04278313 — N/A
Diminished Ovarian Reserve Patient Testimony for trial: Trial Name: NCT04278313 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I register for the experiment?

"This research is seeking 90 individuals with diminished ovarian reserve, lying in the age bracket of 21 to 44. To be considered for inclusion, potential study members are required to present a Follicle Stimulating Hormone level greater than 12; fewer than 6 oocytes collected through ovulation induction; an earnestness to conceive via In Vitro Fertilization techniques; Anti-Mullerian hormone lower than 1.0; and no administration of Aspirin or Motrin within seven days prior to treatment commencement."

Answered by AI

What are the registration requirements for this experiment?

"Clinicaltrials.gov attests that this clinical trial is currently open for enrollment, with the initial post on February 24th 2020 and a recent update provided in November 2021."

Answered by AI

Are individuals over 20 eligible for this research endeavor?

"In agreement with the trial's prerequisites, participants must be between 21 and 44 years old."

Answered by AI

What is the scope of participation in this research endeavor?

"Affirmative. Clinicaltrials.gov states that this clinical trial, which was first posted on February 24th 2020, is recruiting patients. 90 individuals from 1 medical centre need to be enrolled in the study."

Answered by AI

Who else is applying?

What state do they live in?
Pennsylvania
New Jersey
New York
Other
How old are they?
18 - 65
What site did they apply to?
Center for Human Reproduction
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?
1
2
0
3+

Why did patients apply to this trial?

No success with pregnancy in over year and low amh. I have had 2 failed IVF cycles and my insurance doesn’t cover anything at this point .
PatientReceived no prior treatments
I have been researching new treatments that could possible increase our chances of pregnancy.
PatientReceived 1 prior treatment
Iv tried 4 protocols with poor response to all only collected 2 mature eggs from 4 retrievals and at my age this would be my last hope to gain a successful pregnancy.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Email
Most responsive sites:
  1. Center for Human Reproduction: < 24 hours
Average response time
  • < 2 Days
Recent research and studies
clinicaltrials.govStudy
Ovarian Function Following Intraovarian Injection of PRP
2020. "Ovarian Function Following Intraovarian Injection of PRP". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04278313.
~26 spots leftby Dec 2025
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