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PRP Injection for Diminished Ovarian Reserve(PRP4POA Trial)

Led By David H Barad, MD
Research Sponsored by Center for Human Reproduction
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
FSH > 12
fewer than 6 oocytes in response to past ovulation induction
Must not have
Be younger than 18 years old
Be older than 65 years old
Screening 3 weeks
Treatment Varies
Follow Up8 weeks
Awards & highlights

PRP4POA Trial Summary

This trial will test whether Platelet Rich Plasma (PRP) can improve ovarian reserve in women with poor ovarian reserve. Women will be randomly assigned to treatment with either PRP or Platelet Poor Plasma (PPP).

Eligible Conditions
  • Diminished Ovarian Reserve

PRP4POA Trial Eligibility Criteria

Inclusion Criteria

You will be eligible if you check “Yes” for the criteria below
You want to become pregnant through IVF.

PRP4POA Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~8 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 8 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Embryo Transfer
Secondary outcome measures
Antral Follicle Count
Embryos Produced
Other outcome measures

PRP4POA Trial Design

2Treatment groups
Experimental Treatment
Placebo Group
Group I: PRP groupExperimental Treatment1 Intervention
Platelet RICH Plasma prepared using RegenLab FDA approved device.
Group II: PPP groupPlacebo Group1 Intervention
Platelet POOR Plasma prepared using RegenLab FDA approved device.

Find a Location

Who is running the clinical trial?

Center for Human ReproductionLead Sponsor
13 Previous Clinical Trials
1,083 Total Patients Enrolled
David H Barad, MDPrincipal InvestigatorCenter for Human Reproduction
1 Previous Clinical Trials
30 Total Patients Enrolled

Media Library

PPP - Platelet Poor Plasma (Other) Clinical Trial Eligibility Overview. Trial Name: NCT04278313 — N/A
Diminished Ovarian Reserve Research Study Groups: PPP group, PRP group
Diminished Ovarian Reserve Clinical Trial 2023: PPP - Platelet Poor Plasma Highlights & Side Effects. Trial Name: NCT04278313 — N/A
PPP - Platelet Poor Plasma (Other) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04278313 — N/A
Diminished Ovarian Reserve Patient Testimony for trial: Trial Name: NCT04278313 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Can I register for the experiment?

"This research is seeking 90 individuals with diminished ovarian reserve, lying in the age bracket of 21 to 44. To be considered for inclusion, potential study members are required to present a Follicle Stimulating Hormone level greater than 12; fewer than 6 oocytes collected through ovulation induction; an earnestness to conceive via In Vitro Fertilization techniques; Anti-Mullerian hormone lower than 1.0; and no administration of Aspirin or Motrin within seven days prior to treatment commencement."

Answered by AI

What are the registration requirements for this experiment?

"Clinicaltrials.gov attests that this clinical trial is currently open for enrollment, with the initial post on February 24th 2020 and a recent update provided in November 2021."

Answered by AI

Are individuals over 20 eligible for this research endeavor?

"In agreement with the trial's prerequisites, participants must be between 21 and 44 years old."

Answered by AI

What is the scope of participation in this research endeavor?

"Affirmative. Clinicaltrials.gov states that this clinical trial, which was first posted on February 24th 2020, is recruiting patients. 90 individuals from 1 medical centre need to be enrolled in the study."

Answered by AI

Who else is applying?

What state do they live in?
New Jersey
New York
How old are they?
18 - 65
What site did they apply to?
Center for Human Reproduction
What portion of applicants met pre-screening criteria?
Did not meet criteria
Met criteria
How many prior treatments have patients received?

Why did patients apply to this trial?

No success with pregnancy in over year and low amh. I have had 2 failed IVF cycles and my insurance doesn’t cover anything at this point .
PatientReceived no prior treatments
I have been researching new treatments that could possible increase our chances of pregnancy.
PatientReceived 1 prior treatment
Iv tried 4 protocols with poor response to all only collected 2 mature eggs from 4 retrievals and at my age this would be my last hope to gain a successful pregnancy.
PatientReceived 2+ prior treatments

How responsive is this trial?

Typically responds via
Most responsive sites:
  1. Center for Human Reproduction: < 24 hours
Average response time
  • < 2 Days
~32 spots leftby Dec 2025