6 Participants Needed

Pulsed Dye Laser Therapy for Burn Scars

JP
Overseen ByJustin P Gawaziuk, MSc
Age: 18 - 65
Sex: Any
Trial Phase: Academic
Sponsor: University of Manitoba
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)
Approved in 2 JurisdictionsThis treatment is already approved in other countries

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Pulsed Dye Laser Therapy for burn scars?

Research shows that Pulsed Dye Laser (PDL) therapy is effective in treating hypertrophic scars, which are thick, raised scars, and can help improve their appearance. It has been used successfully for scars from surgeries and burns, making it a promising option for burn scars as well.12345

Is pulsed dye laser therapy safe for treating scars?

Research indicates that pulsed dye laser therapy is generally safe for treating scars, with most people experiencing only temporary redness and bruising.12678

How is Pulsed Dye Laser Therapy different from other treatments for burn scars?

Pulsed Dye Laser Therapy (PDL) is unique because it uses a specific wavelength of light to target blood vessels in the skin, which can help reduce redness and improve the appearance of hypertrophic (raised) scars. Unlike some other treatments, PDL is non-invasive and can be precisely controlled to minimize damage to surrounding skin.2491011

What is the purpose of this trial?

The purpose of this study is to determine the effects (good or bad) of pulsed dye laser treatment in burn scar height, texture, redness and pliability in acute burn injury.

Research Team

SL

S Logsetty, MD

Principal Investigator

University of Manitoba

Eligibility Criteria

This trial is for individuals with skin types Fitzpatrick I-III who have burn scars aged one to six months and live in Winnipeg. It's not suitable for those with open wounds, active infections, prior steroid or interferon scar treatments, or a tendency towards keloid scarring.

Inclusion Criteria

Fitzpatrick I-III skin type
Patients with burn scar
Scar age one to 6 months
See 1 more

Exclusion Criteria

Patients with established disposition towards keloid scarring
I currently have an active infection.
I currently have an open wound.
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive pulsed dye laser therapy to assess its effects on burn scar height, texture, vascularity, and pliability

6 months

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Pulsed Dye Laser Therapy
Trial Overview The study is examining the effectiveness of pulsed dye laser therapy on improving the height, texture, redness, and pliability of acute burn scars.
Participant Groups
2Treatment groups
Active Control
Group I: ProximalActive Control1 Intervention
part of scar proximal to heart
Group II: DistalActive Control1 Intervention
part of scar distal to heart

Pulsed Dye Laser Therapy is already approved in United States, European Union for the following indications:

🇺🇸
Approved in United States as Pulsed Dye Laser Therapy for:
  • Port wine stains
  • Hemangiomas
  • Rosacea
  • Telangiectasias
  • Keloids
  • Hypertrophic scars
  • Acne scars
  • Burn scars
🇪🇺
Approved in European Union as Pulsed Dye Laser Therapy for:
  • Port wine stains
  • Hemangiomas
  • Rosacea
  • Telangiectasias
  • Keloids
  • Hypertrophic scars
  • Acne scars
  • Burn scars

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Manitoba

Lead Sponsor

Trials
628
Recruited
209,000+

Findings from Research

The pulsed dye laser (PDL) treatment significantly improved hypertrophic scars in 19 post-thyroidectomy patients, as measured by the Vancouver Scar Scale and three-dimensional imaging, showing reductions in scar height, vascularity, and pigmentation after eight treatment sessions.
The study suggests a cost-effective treatment protocol using the 595 nm PDL, demonstrating consistent efficacy across multiple assessment methods, with significant improvements noted throughout the treatment course.
A prospective study to evaluate the treatment effect of pulsed dye laser on thyroidectomy hypertrophic scars using 3D imaging analysis.Kim, JC., Choi, JW., Kim, YC.[2022]
In a study comparing pulsed-dye laser (PDL) treatment combined with compression therapy (CT) to CT alone in burn scar reconstruction, PDL showed significant improvements in scar characteristics, including reduced redness and height, and increased tissue elasticity after just two or three treatments.
The Vancouver Scar Scale (VSS) indicated that PDL plus CT resulted in better overall scar quality, including improvements in vascularity, pliability, pigmentation, and height compared to CT alone, suggesting that PDL is an effective adjunctive therapy for managing burn scars.
Multimodal quantitative analysis of early pulsed-dye laser treatment of scars at a pediatric burn hospital.Bailey, JK., Burkes, SA., Visscher, MO., et al.[2012]
In a study involving 20 patients with erythematous surgical scars, both the 532-nm KTP laser and the 595-nm PDL laser showed clinical improvement without significant differences in overall efficacy or safety, indicating both are effective treatment options.
The KTP laser specifically demonstrated a statistically significant improvement in the vascularity component of scar assessment, while side effects were minimal and included only mild discomfort and transient redness.
Comparison of 532 nm Potassium Titanyl Phosphate Laser and 595 nm Pulsed Dye Laser in the Treatment of Erythematous Surgical Scars: A Randomized, Controlled, Open-Label Study.Keaney, TC., Tanzi, E., Alster, T.[2015]

References

A prospective study to evaluate the treatment effect of pulsed dye laser on thyroidectomy hypertrophic scars using 3D imaging analysis. [2022]
Multimodal quantitative analysis of early pulsed-dye laser treatment of scars at a pediatric burn hospital. [2012]
Comparison of 532 nm Potassium Titanyl Phosphate Laser and 595 nm Pulsed Dye Laser in the Treatment of Erythematous Surgical Scars: A Randomized, Controlled, Open-Label Study. [2015]
Energy density and numbers of treatment affect response of keloidal and hypertrophic sternotomy scars to the 585-nm flashlamp-pumped pulsed-dye laser. [2007]
Prevention or treatment of hypertrophic burn scarring: a review of when and how to treat with the pulsed dye laser. [2022]
Efficacy of pulsed dye laser combined with fractional CO2 laser in the treatment of pediatric burn scars. [2023]
Efficacy and safety of pulsed dye laser for the treatment of surgical scars: a systematic review and meta-analysis. [2022]
Pulsed dye laser in burn scars: current concepts and future directions. [2015]
Treatment of vascular skin lesions with the variable-pulse 595 nm pulsed dye laser. [2022]
10.United Statespubmed.ncbi.nlm.nih.gov
Laser scar revision: comparison of CO2 laser vaporization with and without simultaneous pulsed dye laser treatment. [2019]
11.United Statespubmed.ncbi.nlm.nih.gov
Effect of pulse width of a 595-nm flashlamp-pumped pulsed dye laser on the treatment response of keloidal and hypertrophic sternotomy scars. [2022]
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