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Device

Repetitive Transcranial Magnetic Stimulation (rTMS) for Depression

N/A
Waitlist Available
Led By David L Brody, MD, PhD
Research Sponsored by Henry M. Jackson Foundation for the Advancement of Military Medicine
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age 18-50 at the time of consent
Current or former US military service member eligible for care at a military treatment facility
Timeline
Screening 3 weeks
Treatment Varies
Follow Up follow-up period, from 1-6 months after the final rtms session
Awards & highlights

Study Summary

This trial will compare three types of rTMS to see which is most effective in treating depression in military service members with a history of concussion.

Eligible Conditions
  • Depression
  • Concussion
  • Traumatic Brain Injury

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~follow-up period, from 1-6 months after the final rtms session
This trial's timeline: 3 weeks for screening, Varies for treatment, and follow-up period, from 1-6 months after the final rtms session for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Mental Depression
Change from Baseline in Montgomery-Asberg Depression Rating Scale (MADRS) Scores in a Subgroup
Change in Montgomery-Asberg Depression Rating Scale (MADRS) Scores from Baseline to 6-month follow-up
+3 more
Secondary outcome measures
Comparison of Change in Inventory of Depressive Symptomatology-Self Report (IDS-SR) Scores from Baseline to 6-month follow-up
Comparison of Change in Inventory of Depressive Symptomatology-Self Report (IDS-SR) Scores from Baseline to post-intervention
Comparison of Change in PTSD Checklist for DSM-5 (PCL-5) Scores from Baseline to 6-month Follow-up
+8 more

Trial Design

16Treatment groups
Experimental Treatment
Placebo Group
Group I: Arm 9Experimental Treatment1 Intervention
Active rTMS/Scalp targeting/Bilateral/Standard rTMS protocol
Group II: Arm 8Experimental Treatment1 Intervention
Active rTMS/Structural targeting/Unilateral/TBS rTMS protocol
Group III: Arm 7Experimental Treatment1 Intervention
Active rTMS/Structural targeting/Unilateral/Standard rTMS protocol
Group IV: Arm 6Experimental Treatment1 Intervention
Active rTMS/Structural targeting/Bilateral/TBS rTMS protocol
Group V: Arm 5Experimental Treatment1 Intervention
Active rTMS/Structural targeting/Bilateral/Standard rTMS protocol
Group VI: Arm 4Experimental Treatment1 Intervention
Active rTMS/ICT/Unilateral/TBS rTMS protocol
Group VII: Arm 3Experimental Treatment1 Intervention
Active rTMS/ICT/Unilateral/Standard rTMS protocol
Group VIII: Arm 2Experimental Treatment1 Intervention
Active rTMS/ICT/Bilateral/Theta Burst Stimulation (TBS) rTMS protocol
Group IX: Arm 12Experimental Treatment1 Intervention
Active rTMS/Scalp targeting/Unilateral/TBS rTMS protocol
Group X: Arm 11Experimental Treatment1 Intervention
Active rTMS/Scalp targeting/Unilateral/Standard rTMS protocol
Group XI: Arm 10Experimental Treatment1 Intervention
Active rTMS/Scalp targeting/Bilateral/TBS rTMS protocol
Group XII: Arm 1Experimental Treatment1 Intervention
Active rTMS/Individualized Connectome Targeting (ICT)/Bilateral/Standard rTMS protocol
Group XIII: Sham 2Placebo Group1 Intervention
Sham rTMS/Scalp targeting/Bilateral laterality/TBS rTMS protocol
Group XIV: Sham 4Placebo Group1 Intervention
Sham rTMS/Scalp targeting/Unilateral/TBS rTMS protocol
Group XV: Sham 1Placebo Group1 Intervention
Sham rTMS/Scalp targeting/Bilateral laterality/Standard rTMS protocol
Group XVI: Sham 3Placebo Group1 Intervention
Sham rTMS/Scalp targeting/Unilateral/Standard rTMS protocol
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Repetitive Transcranial Magnetic Stimulation (rTMS)
2019
Completed Phase 2
~780

Find a Location

Who is running the clinical trial?

Henry M. Jackson Foundation for the Advancement of Military MedicineLead Sponsor
92 Previous Clinical Trials
92,608 Total Patients Enrolled
4 Trials studying Depression
837 Patients Enrolled for Depression
Uniformed Services University of the Health SciencesFED
116 Previous Clinical Trials
91,415 Total Patients Enrolled
2 Trials studying Depression
200 Patients Enrolled for Depression
David L Brody, MD, PhDPrincipal InvestigatorUniformed Services University of the Health Sciences
3 Previous Clinical Trials
539 Total Patients Enrolled
1 Trials studying Depression
10 Patients Enrolled for Depression

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does this therapeutic trial accommodate senior citizens?

"This trial only allows individuals from 18 to 50 years old to participate, while there are other studies catering to minors and seniors respectively with 251 experiments for those under the age of 18, and 1072 trials available for people over 65."

Answered by AI

Are there any unfilled slots for volunteers in this medical experiment?

"Current information on clinicaltrials.gov denotes that this medical study is not actively enrolling patients at the moment, having been initially posted August 17th 2022 and last updated September 28th 2022. Even though recruitment for this specific trial has ceased, there are 1458 other trials open to new participants right now."

Answered by AI

What are the principal aims of this trial?

"This clinical trial's primary objective is to compare the duration of remission in Montgomery-Asberg Depression Rating Scale (MADRS) scores. Secondary outcomes include comparison of change in Symptoms of Major Depressive Disorder Scale (SMDDS), Inventory of Depressive Symptomatology-Self Report (IDS-SR), and TBI Quality Of Life scale subtest scores from baseline to post-intervention, as well as six month follow up periods. The study will track changes on scales ranging from 0 ("Not at all" or "Never") to 4 ("Extremely" or "Always"), with a higher score indicating more severe depressive"

Answered by AI

To what extent are individuals eligible to take part in this experiment?

"This study requires a specific cohort of individuals, namely those suffering from mental depression aged 18 to 50. There are only 1 spots available for this medical trial."

Answered by AI
~0 spots leftby Mar 2025