30 Participants Needed

Task-Specific Exercise for Multiple Sclerosis

Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: New York Presbyterian Brooklyn Methodist Hospital
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of this study is to compare the effectiveness of 2 different types of Home Exercise Programs (HEP) on mobility in persons with Multiple Sclerosis (MS). Specifically, we will be comparing the Standard of Care (SOC) a program based on aerobic conditioning and calisthenics to a Task Specific Program (TSP). Primary Question: Will persons with who receive a Task Specific HEP have greater improvement in mobility than those who receive the SOC? Secondary question: Will a task specific HEP be as well tolerated as the SOC HEP by persons with MS

Do I need to stop my current medications for this trial?

The trial information does not specify whether you need to stop taking your current medications.

What data supports the effectiveness of the treatment Task Specific Home Exercise Program, Task Specific Home Exercise Program, Task Oriented Circuit Training, Home-Based Task-Oriented Program for Multiple Sclerosis?

Research shows that task-oriented training, including circuit training, can help improve motor function, walking abilities, and quality of life in people with Multiple Sclerosis. These programs are designed to be intensive and can be done at home, making them accessible and potentially beneficial for managing symptoms.12345

Is task-specific exercise safe for people with Multiple Sclerosis?

A study evaluating task-oriented circuit training in people with Multiple Sclerosis found it to be safe and feasible, suggesting it can be done without significant risk.12456

How is the Task Specific Home Exercise Program treatment different from other treatments for Multiple Sclerosis?

The Task Specific Home Exercise Program is unique because it combines supervised and home-based task-oriented circuit training, focusing on improving motor and cognitive performance through specific tasks. This approach is designed to enhance walking abilities and conditioning, offering a structured yet flexible exercise routine that can be adapted to individual needs, unlike standard treatments that may not be as personalized or task-focused.12357

Eligibility Criteria

This trial is for individuals with Multiple Sclerosis who are looking to improve their mobility. Participants should be able to perform exercises at home and commit to the program's duration. Specific eligibility criteria details were not provided, so interested individuals should contact the study organizers for more information.

Inclusion Criteria

I can walk for at least 30 seconds by myself, with or without help from a device.
I have been officially diagnosed with Multiple Sclerosis.
I am between 18 and 75 years old.
See 2 more

Exclusion Criteria

I have had a recent flare-up of my MS.
I don't have any health issues that stop me from joining a physical therapy program.
I am currently undergoing physical therapy as an outpatient.

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants engage in either a Task Specific Home Exercise Program or a Standard of Care Home Exercise Program

8 weeks
Home-based exercise with periodic assessments

Follow-up

Participants are monitored for safety and effectiveness after treatment

4 weeks

Treatment Details

Interventions

  • Task Specific Home Exercise Program
Trial OverviewThe study compares two home exercise programs: a Standard of Care (SOC) program focusing on aerobic conditioning and calisthenics, versus a Task Specific Program (TSP) designed for improving specific mobility tasks in people with MS.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Individualized Task Specific Physical Therapy Home Exercise ProgramExperimental Treatment1 Intervention
Physical Therapy Home Exercise program based on specific outcome measure findings.
Group II: Generic physical therapy home exercise programActive Control1 Intervention
Generalized fitness-based exercise program

Find a Clinic Near You

Who Is Running the Clinical Trial?

New York Presbyterian Brooklyn Methodist Hospital

Lead Sponsor

Trials
21
Recruited
3,900+

Findings from Research

Task-oriented circuit training (TOCT) significantly improved balance and walking performance in 20 patients with Multiple Sclerosis over six weeks, while the control group showed no changes.
Cognitive performance and manual dexterity did not show significant improvements with TOCT, indicating that while physical aspects of performance benefit, cognitive effects require further investigation.
Effect of task-oriented circuit training on motor and cognitive performance in patients with multiple sclerosis: A single-blinded randomized controlled trial.Ozkul, C., Guclu-Gunduz, A., Eldemir, K., et al.[2020]
A two-week intensive task-oriented circuit training (TOCT) program significantly improved knee joint dynamics in MS patients with mild to moderate disability, particularly in those with pyramidal impairments.
The study involved 19 MS patients and showed that while overall gait dynamics improved, the benefits were more pronounced in patients with pyramidal impairments compared to those with cerebellar impairments, suggesting targeted rehabilitation strategies may be necessary.
An intensive task-oriented circuit training positively impacts gait biomechanics in MS patients.Tramonti, C., Di Martino, S., Chisari, C.[2020]
A combination of 2 weeks of supervised task-oriented circuit training followed by 12 weeks of a home-based program significantly improved walking endurance and ability in patients with Multiple Sclerosis, as evidenced by better scores on the Six Minute Walk Test and other mobility assessments.
The intervention also led to improvements in fatigue and resting muscle oxygen consumption, suggesting it not only enhances physical capabilities but may also help reduce physical deconditioning in patients with unassisted walking.
Combining a supervised and home-based task-oriented circuit training improves walking endurance in patients with multiple sclerosis. The MS_TOCT randomized-controlled trial.Straudi, S., De Marco, G., Martinuzzi, C., et al.[2022]

References

Effect of task-oriented circuit training on motor and cognitive performance in patients with multiple sclerosis: A single-blinded randomized controlled trial. [2020]
An intensive task-oriented circuit training positively impacts gait biomechanics in MS patients. [2020]
Combining a supervised and home-based task-oriented circuit training improves walking endurance in patients with multiple sclerosis. The MS_TOCT randomized-controlled trial. [2022]
A task-oriented circuit training in multiple sclerosis: a feasibility study. [2021]
Intensity-dependent clinical effects of an individualized technology-supported task-oriented upper limb training program in Multiple Sclerosis: A pilot randomized controlled trial. [2020]
Home-Based Exercise Training in Multiple Sclerosis: A Systematic Review with Implications for Future Research. [2021]
Effect of task related circuit training on walking ability in a Multiple Sclerosis subject. A single case study. [2012]