Ketamine for Pelvic Pain
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to determine if adding ketamine to standard anesthesia can reduce post-surgery pain for individuals with endometriosis. Ketamine, typically used during surgery to induce sleep, will be administered to participants randomly assigned to receive either regular anesthesia or regular anesthesia with ketamine during their laparoscopic surgery. The trial seeks participants undergoing outpatient laparoscopic surgery for endometriosis who can complete short surveys about their post-surgery pain. As a Phase 4 trial, this research explores how the already FDA-approved and effective treatment benefits a broader range of patients.
Do I need to stop my current medications to join the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What is the safety track record for ketamine?
Research has shown that ketamine is generally safe in medical settings such as surgery. The FDA has approved ketamine for use as anesthesia, indicating it has undergone safety testing. In studies where ketamine provided pain relief, many patients reported improvement without serious side effects. However, recreational use of ketamine can cause bladder problems, though this is not typically a concern in a controlled medical environment. Overall, ketamine is considered safe for surgical use.12345
Why are researchers enthusiastic about this study treatment?
Unlike the standard treatments for pelvic pain, which often include medications like NSAIDs and opioids, ketamine offers a novel approach by acting on the brain's glutamate system. This mechanism is different from typical pain relievers, which usually target inflammatory pathways or opioid receptors. Researchers are excited about ketamine because it might provide rapid pain relief and potentially help people who haven't found success with other treatments. Additionally, ketamine's unique action on the nervous system could offer new insights into managing chronic pain conditions.
What evidence suggests that ketamine might be an effective treatment for pelvic pain?
Research shows that ketamine can help reduce pain after surgery. Studies have found that ketamine provides strong pain relief during administration, and some patients continue to feel better even after treatment ends. In this trial, one group will receive standard general anesthesia with ketamine, potentially offering quick relief for pelvic pain that may persist for weeks or months. Another group will receive standard general anesthesia without ketamine. Ketamine is well-known and approved for medical use as part of anesthesia in surgeries.25678
Who Is on the Research Team?
Morgan Cheeks, MD
Principal Investigator
University Hosptials
Adi Cosic, DO
Principal Investigator
University Hospitals
Are You a Good Fit for This Trial?
This trial is for individuals undergoing surgery who experience conditions like endometrial thinning, endometriosis, or pelvic pain. Participants must be eligible for the surgical procedure and able to provide feedback on their pain levels after surgery.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Patients undergo surgery with standard anesthesia, with or without ketamine infusion
Post-operative Observation
Patients rate their pain in the post-operative observation unit
Follow-up
Participants are monitored for pain and analgesic consumption at their two-week post-operative visit
What Are the Treatments Tested in This Trial?
Interventions
- Ketamine
Find a Clinic Near You
Who Is Running the Clinical Trial?
University Hospitals Cleveland Medical Center
Lead Sponsor