Acular Ls

Eye Pain, Inflammation, corneal refractive surgery + 20 more
Treatment
2 FDA approvals
20 Active Studies for Acular Ls

What is Acular Ls

KetorolacThe Generic name of this drug
Treatment SummaryKetorolac is a non-steroidal anti-inflammatory drug (NSAID) used to reduce pain. It comes in the form of tablets, injections, nasal spray, and eye drops. Ketorolac is commonly used to treat postoperative pain, rheumatoid arthritis, osteoarthritis, menstrual disorders, headaches, spinal and soft tissue pain, and ankylosing spondylitis. It works as well as morphine and meperidine but without the side effects of opioids.
Toradolis the brand name
image of different drug pills on a surface
Acular Ls Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Toradol
Ketorolac
1991
316

Approved as Treatment by the FDA

Ketorolac, also called Toradol, is approved by the FDA for 2 uses like caudal epidural block therapy and induction of Nerve Block .
caudal epidural block therapy
Used to treat caudal epidural block therapy in combination with Bupivacaine
induction of Nerve Block
Used to treat induction of Nerve Block in combination with Bupivacaine

Effectiveness

How Acular Ls Affects PatientsKetorolac is a non-selective painkiller that works by blocking the enzymes responsible for producing substances that contribute to inflammation and pain. Blocking the COX-1 enzyme can lead to an increased risk of bleeding and stomach ulcers, while blocking the COX-2 enzyme is what causes the desired anti-inflammatory and pain relief effects. However, it is not recommended to take ketorolac long-term as this can lead to dangerous side effects such as stomach bleeding, ulcers, and perforations.
How Acular Ls works in the bodyKetorolac helps reduce pain and inflammation by blocking the pathways that create prostaglandins. It works by targeting two enzymes, COX-1 and COX-2, but mainly works on the COX-2 enzyme. This enzyme is responsible for converting arachidonic acid into prostaglandins, which cause inflammation and pain. By blocking this pathway, ketorolac stops the creation of these prostaglandins and reduces pain and inflammation. It is usually given as a racemic mixture, but the "S" enantiomer is mainly responsible for its effects.

When to interrupt dosage

The prescribed measure of Acular Ls is contingent upon the indicated condition, including Eye, Macular Edema, Cystoid and Pericarditis Acute. The magnitude of dosage is subject to the method of administration (e.g. Tablet - Oral or Ophthalmic) delineated in the following table.
Condition
Dosage
Administration
Macular Edema, Cystoid
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Miosis disorder
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Seasonal Allergic Conjunctivitis
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Cataract Surgery
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Ocular Itching
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Eye Pain
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Intraocular Lens Replacement
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Macular Edema, Cystoid
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
postoperative ocular pain
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Pain
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
caudal epidural block therapy
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Macular Edema
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Acute Coryza
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Pupil
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
induction of Nerve Block
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
induction of Local Anaesthesia
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Pericarditis Acute
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Inflammation
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
corneal refractive surgery
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular
Induced Hyperthermia
, 5.0 mg/mL, 4.5 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 10.0 mg, 15.75 mg, 4.0 mg/mL, 5.0 mg, 60.0 mg/mL, 0.5 %, 0.4 %, 0.45 %, 2.88 mg/mL, 0.4 mg/mL, 40.0 mg/mL, 3.0 mg/mL, 9.0 mg/mL, 50.0 mg/mL, 45.0 mg/mL, 0.5 mg/mL, 10.0 mg/mL
Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, , Intramuscular; Intravenous, Injection, Injection - Intramuscular; Intravenous, Nasal, Spray, metered, Spray, metered - Nasal, Intramuscular, Injection - Intramuscular, Tablet, Tablet - Oral, Solution, Solution - Ophthalmic, Injection, solution, Injection, solution - Intramuscular; Intravenous, Injection, solution - Intramuscular, Intravenous, Injection, solution - Intravenous, Liquid - Intramuscular, Solution - Intramuscular, Injection, solution, concentrate - Intraocular, Injection, solution, concentrate, Intraocular, Kit, Oral, Liquid, Infiltration; Intramuscular; Intravenous; Topical, Kit - Infiltration; Intramuscular; Intravenous; Topical, Injection, solution - Ophthalmic, Epidural; Infiltration; Intramuscular; Intravenous, Topical, Epidural; Infiltration; Intramuscular; Intravenous; Topical, Spray, metered - Topical, Kit - Epidural; Infiltration; Intramuscular; Intravenous; Topical, Tablet, film coated, Tablet, film coated - Oral, Kit - Epidural; Infiltration; Intramuscular; Intravenous, Solution, concentrate, Solution, concentrate - Intraocular; Irrigation, Intraocular; Irrigation, Kit - Ophthalmic, Injection, solution - Intraocular

Warnings

Acular Ls Contraindications
Condition
Risk Level
Notes
Heart failure
Do Not Combine
Hyperkalemia
Do Not Combine
Renal Insufficiency
Do Not Combine
Hemorrhagic Disorders
Do Not Combine
Kidney Failure
Do Not Combine
A History of Gastric or Duodenal Ulcers
Do Not Combine
Liver Diseases
Do Not Combine
Major Surgery
Do Not Combine
Pulse Frequency
Do Not Combine
Gastrointestinal Hemorrhage
Do Not Combine
Crohn's Disease
Do Not Combine
suspected cerebrovascular bleeding
Do Not Combine
active Gastrointestinal Bleeding
Do Not Combine
NSAID-Induced Asthma
Do Not Combine
Severe Hepatic Impairment
Do Not Combine
incomplete hemostasis
Do Not Combine
Coronary Artery Bypass Grafting
Do Not Combine
Gastrointestinal Perforation
Do Not Combine
Pulse Frequency
Do Not Combine
Hemorrhage
Do Not Combine
Peptic Ulcer
Do Not Combine
Pulse Frequency
Do Not Combine
Labour
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Third trimester of pregnancy
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Ketorolac may interact with Pulse Frequency
Severe Hypersensitivity Reactions
Do Not Combine
Ketorolac may interact with Pulse Frequency
There are 20 known major drug interactions with Acular Ls.
Common Acular Ls Drug Interactions
Drug Name
Risk Level
Description
Aceclofenac
Major
The risk or severity of adverse effects can be increased when Ketorolac is combined with Aceclofenac.
Acemetacin
Major
The risk or severity of adverse effects can be increased when Ketorolac is combined with Acemetacin.
Acetylsalicylic acid
Major
The risk or severity of adverse effects can be increased when Ketorolac is combined with Acetylsalicylic acid.
Alclofenac
Major
The risk or severity of adverse effects can be increased when Ketorolac is combined with Alclofenac.
Alminoprofen
Major
The risk or severity of adverse effects can be increased when Ketorolac is combined with Alminoprofen.
Acular Ls Toxicity & Overdose RiskTaking ketorolac may cause abdominal pain, indigestion, nausea, and headaches in more than 10% of patients. Other common symptoms of an overdose include vomiting, epigastric pain, gastrointestinal bleeding, fatigue and drowsiness, kidney damage or failure, high blood pressure, and coma. Women who are pregnant or nursing should exercise caution when taking ketorolac as it can be passed through breast milk and may cause premature closure of the fetal ductus arteriosus. Women who are trying to conceive should avoid taking ketorolac as it may affect fertility.
image of a doctor in a lab doing drug, clinical research

Acular Ls Novel Uses: Which Conditions Have a Clinical Trial Featuring Acular Ls?

188 active clinical trials are presently analyzing the potential of Acular LS to ameliorate Macular Edema, Cystoid, acute, moderate Pain and Intraocular Lens Replacement.
Condition
Clinical Trials
Trial Phases
Inflammation
59 Actively Recruiting
Not Applicable, Early Phase 1, Phase 1, Phase 2, Phase 3, Phase 4
Induced Hyperthermia
0 Actively Recruiting
caudal epidural block therapy
6 Actively Recruiting
Not Applicable, Phase 4, Phase 3, Phase 2
Intraocular Lens Replacement
0 Actively Recruiting
Acute Coryza
0 Actively Recruiting
Macular Edema, Cystoid
0 Actively Recruiting
induction of Nerve Block
0 Actively Recruiting
Pupil
0 Actively Recruiting
Local Anaesthesia therapy
0 Actively Recruiting
corneal refractive surgery
0 Actively Recruiting
Seasonal Allergic Conjunctivitis
0 Actively Recruiting
Eye Pain
0 Actively Recruiting
postoperative ocular pain
0 Actively Recruiting
Eye
0 Actively Recruiting
Ocular Itching
0 Actively Recruiting
Pericarditis Acute
1 Actively Recruiting
Phase 2, Phase 3
Miosis disorder
0 Actively Recruiting
Macular Edema, Cystoid
0 Actively Recruiting
Macular Edema
1 Actively Recruiting
Phase 1, Phase 2
Cataract Surgery
3 Actively Recruiting
Not Applicable, Phase 4

Acular Ls Reviews: What are patients saying about Acular Ls?

5Patient Review
3/11/2008
Acular Ls for Postoperative Pain in Eye
This medication has a bit of a burning sensation upon application, but it subsides quickly.
5Patient Review
8/12/2008
Acular Ls for Eye Irritation
This medicine is amazing! I had a scratch at the back of my eye that was causing me so much pain, but after taking this it just vanished. Best sleep ever!
3Patient Review
10/27/2008
Acular Ls for Inflammation of the Eye Following Surgery
About a week after my cataract surgery, I started using this treatment four times daily. The day after I stopped, I developed throbbing and redness in the affected eye, as well as tearing. I'm seeing my eye surgeon tomorrow, but in the meantime, does anyone know if this is normal?
1.7Patient Review
6/17/2009
Acular Ls for Eye Irritation
I was very disappointed with this treatment. It did nothing to ease my pain, even temporarily, and it was quite expensive.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about acular ls

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long can you use ACULAR eye drops?

"The recommended length of use for ACULAR® eye drops is 2-4 weeks, as prescribed by a doctor."

Answered by AI

What is Acular LS used for?

"NSAIDs are a type of medication used to relieve pain, burning, and stinging. Ketorolac is a specific NSAID that is used to relieve symptoms following corneal refractive surgery."

Answered by AI

Are ACULAR eye drops an antibiotic?

"Acular is a nonsteroidal anti-inflammatory drug (NSAID) that is used to relieve itching in the eyes that is caused by seasonal allergies. Acular is also used to reduce swelling, pain, and burning or stinging after cataract surgery or corneal refractive surgery."

Answered by AI

Is ACULAR eye drops a steroid?

"Acular (ketorolac eye drops) belongs to a class of drugs called non-steroidal anti-inflammatory drugs (NSAIDs), which is different from steroids. Even though they are different types of drugs, steroids and NSAIDs are often used for similar conditions, such as eye pain or inflammation."

Answered by AI

Clinical Trials for Acular Ls

Image of McGill University Health Centre in Montreal, Canada.

Dexmedetomidine for Pain Relief

18 - 75
All Sexes
Montreal, Canada
This study will compare three different doses of perineural dexmedetomidine 0.67 mcg/kg, 1 mcg/kg, and 1.33 mcg/kg as adjuvants to local anesthetics for ultrasound-guided infraclavicular brachial plexus blocks (ICBs). Our research hypothesis is that 1.33 mcg/kg will provide a 15%-longer duration than 1mcg/kg, which in turn will provide a 15%-longer duration than 0.67 mcg/kg. Since analgesic duration and sensory duration can be influenced by intake of pain medications and surgical trauma to small cutaneous nerves, respectively, we will select motor block duration as the main outcome to better target the action of dexmedetomidine on the brachial plexus.
Phase 2
Waitlist Available
McGill University Health CentreJulián Aliste, MD
Image of University of California, San Francisco in San Francisco, United States.

Vision Centers for Eye Care

Any Age
All Sexes
San Francisco, CA
The goal of this clinical trial is to evaluate the effect of vision centers on access to eye care and eye health outcomes in South Asia. The main questions it aims to answer are: 1. Do vision centers increase visits to eyecare centers? 2. Do vision centers increase spectacle ownership and wearing? 3. Do vision centers improve visual acuity of the population? Researchers will compare outcomes in communities randomized to have a vision center is established with communities randomized to delay establishment of a vision center. Outcomes will be assessed through population-based surveys at baseline and after two years as well as through hospital records collected throughout the study period.
Waitlist Available
Has No Placebo
University of California, San FranciscoKieran O'Brien, PhD, MPH
Image of UConn Health in Farmington, United States.

Cognitive Remediation for Memory and Thinking Difficulties

18+
All Sexes
Farmington, CT
The goal of this clinical trial is to determine if a neuroscience-based computerized cognitive remediation ("brain training") program can treat neurocognitive dysfunction (i.e., memory or thinking difficulties) that emerges in some older adults following a viral infection. The main questions it aims to answer are: * Does computerized cognitive remediation improve cognitive performance and day-to-day functioning in older adults with postviral neurocognitive dysfunction? * Will treatment effects be maintained over time, leading to better long term cognitive outcomes? * Does the treatment lead to reductions in blood-based markers of inflammation as a potential mechanism of cognitive symptom improvement? * Can the treatment be optimized and refined based on feedback from participants to improve user (patient) experience? Researchers will compare the computerized cognitive remediation program to an active computer-based control condition (alternative computer activities) to see if the computerized cognitive remediation program works to treat postviral neurocognitive dysfunction. Participation takes approximately 43-48 hours over 7 months, with most activities (40-46 hours) completed within the first 7-8 weeks, including: * Initial intake visit: Eligibility confirmation (\~2-3 hours) * Computer activities: About 5 hours per week for \~6 weeks (total \~30 hours) completed on a computer tablet provided by the study and loaned to participants for use during the treatment phase * Weekly remote check-in meetings: \~30 minutes each during treatment * Blood draws: Two sessions (before and after treatment), \~20-30 minutes each * Three research visits: Pre-treatment, post-treatment, and 6-month follow-up (\~2-3 hours each, including assessments of cognitive, emotional, and daily functioning)
Waitlist Available
Has No Placebo
UConn HealthCutter Lindbergh, Ph.D.
Have you considered Acular Ls clinical trials? We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.Go to Trials
Image of Mount Sinai Hospital in Toronto, Canada.

Intrathecal Morphine for Urinary Retention

18+
All Sexes
Toronto, Canada
Revision total knee arthroplasty (rTKA) is a frequently performed procedure. Adequate pain management is an important feature, especially for fast-track and Enhanced Recovery After Surgery (ERAS) programs. The multimodal approach, including single shot or continuous nerve blocks with catheters and spinal or epidural morphine, is a stablished strategy. Although the administration of intrathecal morphine (IM) has been shown to significantly reduce pain scores, it is not free of adverse effects. Postoperative urinary retention (POUR) is possible and might increase the risk of periprosthetic infection. The purpose of this study is to compare patients undergoing rTKAS under spinal anesthesia with IM to patients undergoing the same procedure, under the same anesthetic technique, but with no IM, for POUR and postoperative pain related outcomes. All patients will have single shot and continuous adductor canal block (CACB) and single shot IPACK (interspace between the popliteal artery and the posterior knee capsule) block. The hypothesis is that postoperative pain control is comparable between the groups, with lower incidence of POUR in patients with no IM given.
Phase 3
Recruiting
Mount Sinai HospitalHermann dos Santos Fernandes, MD, PhD
Image of Abcentra Investigational Site in Los Angeles, United States.

Orticumab for Heart Attack

18+
All Sexes
Los Angeles, CA
The goal of this clinical trial is to determine the clinical effect of orticumab treatment on inflammation in study participants with prior myocardial infarction who have elevated coronary inflammation based on CCTA. The main question it aims to answer is: Clinical effects of orticumab treatment on inflammation of the coronary artery parameters measured with CCTA Researchers will compare the effects with placebo group after 6 months of treatment Participants will Keep the planned study visit appointments Provide complete information about medical and medical history Speak to the study doctor before changing any of non-study treatments, including starting new medications, receiving any vaccinations, or setting out to join any other clinical studies
Phase 2
Recruiting
Abcentra Investigational Site (+6 Sites)Abcentra
Have you considered Acular Ls clinical trials? We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.Go to Trials
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Biophoton Therapy for Stem Cell Proliferation

18 - 70
All Sexes
Tampa, FL
Study Objective The purpose of this clinical study is to evaluate if biophoton therapy, delivered by Tesla BioHealing® Biophoton Generators (Biophotonizer), can increase self-grown stem cells naturally. Study Design This is a randomized, double-blinded, placebo-controlled intervention clinical study to assess the effectiveness of biophoton therapy in impacting stem cells. Approximately 46 volunteers who want to increase self-grown stem cells will participate in the study. Study Randomization The biostatistician will prepare a randomization schedule including a serial of subject numbers. A subject number will be randomly assigned to each study participant, which will assign them to either the control group or the treatment group. Other than the Informed Consent Form (ICF), all study information will be recorded by using the subject number. The Principal Investigator, study physicians, study nurse, data-entry specialists, and biostatisticians, as well as the participants, will be blinded about who received which product during the first two weeks of study participation.
Recruiting
Online Trial
Tesla MedBed at Tampa-FL (+1 Sites)James Z Liu, MD, PhD
Image of Goldring Center for High Performance Sport in Toronto, Canada.

Physical Activity for Delayed Onset Muscle Soreness

18 - 35
All Sexes
Toronto, Canada
After completing novel activity or exercise we may experience exercise-induced muscle damage (EIMD), resulting in a period of reduced muscle function and delayed onset muscle soreness (DOMS). DOMS is characterized by muscle pain and tenderness that typically resolves within a week. While the precise cause of DOMS is unknown, there is growing evidence implicating damage to the connective tissue that surrounds our muscle fibers and is related to a small amount of inflammation. This inflammation is a normal part of our body's ability to recovery from injuries and may be visualized through the use of ultrasound technology. A variety of recovery techniques have been proposed that may help with the recovery of DOMS such as massage and electrical muscle stimulation, but these are not always accessible. Therefore, we are interested in investigating whether the number of daily steps can affect how you experience DOMS.
Waitlist Available
Has No Placebo
Goldring Center for High Performance Sport
Image of UCSF in San Francisco, United States.

Moisturizers for Aging

65+
All Sexes
San Francisco, CA
This is a randomized, investigator-blinded, self-controlled pilot study of the physiologic response to topical moisturizers among older adults with dry skin. The overarching hypothesis is that skin barrier decline is an important source of chronic inflammation, and that skin barrier restoration with moisturizers can reduce serum biomarkers of inflammation. The primary objective is to determine the feasibility for a larger trial, and the secondary objectives are to determine the extent to which measures of serum inflammation, skin barrier function, and the skin microbiome change in response to moisturizers. Participants will be asked to apply one of two topical moisturizers that are widely available over the counter in the US (Vaseline® 100% pure petroleum jelly or CeraVe® moisturizing cream) once daily for 4 weeks to the front of the torso, buttocks, arms, and legs. Subjects will act as their own control (i.e. they will be asked to apply the study moisturizer they are randomized to for one intervention period (4 weeks) and not to apply topical moisturizers for the other 4- week intervention period). Participants will be randomized in a 1:1:1:1 ratio to one of 4 treatment groups: i. no intervention then CeraVe; ii. CeraVe then no intervention; iii. no intervention then Vaseline; iv. Vaseline then no intervention. At each visit (baseline, week 4, and week 8), participants will undergo skin barrier testing, skin microbiome sampling, and phlebotomy to measure serum inflammatory markers.
Phase 4
Recruiting
UCSFKatrina Abuabara, MD
Have you considered Acular Ls clinical trials? We made a collection of clinical trials featuring Acular Ls, we think they might fit your search criteria.Go to Trials
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