Rexulti

Schizophrenia, Depression, Antidepressants
Treatment
20 Active Studies for Rexulti

What is Rexulti

BrexpiprazoleThe Generic name of this drug
Treatment SummaryBrexpiprazole is a medication prescribed to treat schizophrenia and major depressive disorder (MDD). It works by modulating the activity of serotonin and dopamine in the brain, while also blocking serotonin 2A receptors. Brexpiprazole has been designed to provide better results than other treatments for depression, with fewer side effects such as restlessness and insomnia.
Rexultiis the brand name
image of different drug pills on a surface
Rexulti Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rexulti
Brexpiprazole
2015
22

Effectiveness

How Rexulti works in the bodyBrexpiprazole helps treat depression and schizophrenia, but exactly how it works is not known. It appears to work by partially activating serotonin and dopamine receptors, while blocking serotonin 2A receptors.

When to interrupt dosage

The amount of Rexulti is contingent upon the indicated disorder, including Depression, Schizophrenia and Antidepressive Agents. The measure of dosage is subject to the mode of administration (e.g. Oral or Kit; Tablet) featured in the table beneath.
Condition
Dosage
Administration
Antidepressants
0.25 mg, , 0.5 mg, 1.0 mg, 2.0 mg, 3.0 mg, 4.0 mg
, Tablet, Oral, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Depression
0.25 mg, , 0.5 mg, 1.0 mg, 2.0 mg, 3.0 mg, 4.0 mg
, Tablet, Oral, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral
Schizophrenia
0.25 mg, , 0.5 mg, 1.0 mg, 2.0 mg, 3.0 mg, 4.0 mg
, Tablet, Oral, Tablet - Oral, Kit; Tablet, Kit; Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Rexulti has one restriction. Therefore, it should not be consumed when any of the conditions outlined in the table below are present.Rexulti Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Brexpiprazole may interact with Pulse Frequency
There are 20 known major drug interactions with Rexulti.
Common Rexulti Drug Interactions
Drug Name
Risk Level
Description
Alfuzosin
Major
Brexpiprazole may increase the hypotensive activities of Alfuzosin.
Amisulpride
Major
Brexpiprazole may increase the antipsychotic activities of Amisulpride.
Aripiprazole lauroxil
Major
Brexpiprazole may increase the orthostatic hypotensive, hypotensive, and antihypertensive activities of Aripiprazole lauroxil.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Brexpiprazole.
Azelastine
Major
Brexpiprazole may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Rexulti Toxicity & Overdose RiskCommon side effects of antipsychotic drugs include weight gain, restlessness, fatigue, trembling, and a sore throat. Babies exposed to antipsychotics during the third trimester of pregnancy may experience symptoms such as muscle stiffness or withdrawal.
image of a doctor in a lab doing drug, clinical research

Rexulti Novel Uses: Which Conditions Have a Clinical Trial Featuring Rexulti?

There are currently 356 active studies investigating the efficacy of Rexulti in treating Depression, Schizophrenia and other Antidepressive-related ailments.
Condition
Clinical Trials
Trial Phases
Depression
200 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Phase 4, Early Phase 1
Antidepressants
0 Actively Recruiting
Schizophrenia
177 Actively Recruiting
Not Applicable, Phase 3, Phase 2, Early Phase 1, Phase 4, Phase 1

Rexulti Reviews: What are patients saying about Rexulti?

4.3Patient Review
6/24/2022
Rexulti for Additional Medications to Treat Depression
So far, Rexulti has been working well for me in combination with Lexapro. If you're considering this medication for depression, just know that you should also be taking an antidepressant. I'd say it's worth giving Rexulti a chance if you're starting out.
4Patient Review
1/26/2022
Rexulti for Major Depressive Disorder
I've been taking this medication for a few years now and it's really helped me become more stable and level-headed. I used to have a lot of negative and racing thoughts, but that has reduced significantly. I'm also a lot less snippy and short tempered. Additionally, I've even lost 50 pounds since starting the medication–which is great considering I'm still 80 pounds overweight. Thankful for modern medicine indeed.
2.7Patient Review
9/5/2022
Rexulti for Major Depressive Disorder
This medication helped with my anxiety, but the restlessness and increased appetite were too much to handle. I had to stop taking it.
2.7Patient Review
9/24/2021
Rexulti for Additional Medications to Treat Depression
I didn't see many results from this treatment, even after taking it for several months. The only real changes I noticed were weight gain and fatigue.
2.3Patient Review
9/5/2022
Rexulti for Major Depressive Disorder
At first, this medication was highly effective for me. However, the longer I took it, the more my emotions became blunted. Eventually, I had to stop taking the medication entirely due to the lack of feelings.
2Patient Review
1/10/2022
Rexulti for Additional Medications to Treat Depression
Unfortunately, this medication caused my throat to close up and I had a lot of trouble swallowing. This then led to me having my first panic attack as I felt like I couldn't breathe. It was awful and scary. Thankfully, after stopping the medication and having an endoscopy done to fix my throat, I finally started feeling normal again after about three months.
1.3Patient Review
2/28/2022
Rexulti for Major Depressive Disorder
I had the Mirena IUD inserted which stopped my periods. Rexulti, however, brought them back with a vengeance after about six months. When I stopped taking Rexulti for just three days, the periods went away; but as soon as I started up again, they came back full force and lasted over nine days. Needless to say, I'll be stoppingRexulti--the benefits are not worth it.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about rexulti

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Rexulti the same as Abilify?

"The company Otsuka claims that the drug Rexulti has a stronger activity at dopamine (D2) receptors as well as 5-HT2A serotonin receptors than the drug Abilify. They say that these attributes make Rexulti an improvement on Abilify, but only time will tell whether or not this is the actually the case."

Answered by AI

Is Rexulti good for depression?

"Adding Rexulti to ongoing antidepressant treatment led to a 62% greater reduction in symptoms of depression in a 6-week long study in adults."

Answered by AI

Is Rexulti an antidepressant?

"Rexulti may cause serious side effects, including:

Suicidal thoughts or actions

Abnormal bleeding

Swelling of the hands, legs, and feet

High blood sugar

Low sodium levels in the blood

Low white blood cell counts

Liver problems

Low platelet counts

Rexulti may cause other side effects. Call your doctor if you have any unusual problems while taking this medication.

Rexulti is a prescription medicine used to treat adults with major depressive disorder (MDD).

Rexulti is not approved for use in children.

Important Safety Information

Suicidal Thoughts and Actions

Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term studies. These studies did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in patients over age 24; there was a reduction in risk with antidepressant use in patients aged 65 and older.

Depression and other serious mental illnesses are themselves associated with increases in the risk of suicide. Patients of all ages who are started on antidepressant therapy should be monitored appropriately and observed closely for clinical worsening, suicidality, or unusual changes in behavior. Families and caregivers should be advised of the need for close observation and communication with the prescriber. Rexulti is not approved for use in pediatric patients.

Abnormal Bleeding

Rexulti and other antidepressant medicines may increase your risk of bleeding or bruising, especially if you take the blood thinner warfarin (Coumadin®, Jantoven®), a non-steroidal anti-inflammatory drug (NSAIDs, like ibuprofen or naproxen), or aspirin.

Swelling of the Hands, Legs, and Feet

Rexulti and other antidepressant medicines may increase your risk of swelling, especially of your hands, legs, and feet. Tell your doctor if you have swelling in any of these areas."

Answered by AI

What is Rexulti used to treat?

"This medication is used to manage certain mental/mood disorders (e.g. schizophrenia, depression). It helps patients to think more clearly, feel less anxious, and participate in everyday activities. Additionally, it may diminish hallucinations (e.g. hearing/seeing things that are not actually there)."

Answered by AI

How does Rexulti make you feel?

"Most of the side effects associated with REXULTI are common, such as weight gain and feeling restless. These were reported during clinical studies of adults with major depressive disorder."

Answered by AI

Is Abilify the same as Rexulti?

"Otsuka Pharmaceuticals claims that Rexulti has a stronger effect on dopamine (D2) receptors and 5-HT2A serotonin receptors than Abilify. They say that this makes Rexulti an improvement on Abilify, but only time will tell if this is truly the case."

Answered by AI

Clinical Trials for Rexulti

Have you considered Rexulti clinical trials? We made a collection of clinical trials featuring Rexulti, we think they might fit your search criteria.
Have you considered Rexulti clinical trials? We made a collection of clinical trials featuring Rexulti, we think they might fit your search criteria.
Have you considered Rexulti clinical trials? We made a collection of clinical trials featuring Rexulti, we think they might fit your search criteria.