Nifedipine

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more
Treatment
3 FDA approvals
20 Active Studies for Nifedipine

What is Nifedipine

NifedipineThe Generic name of this drug
Treatment SummaryNifedipine, also known as BAY a 1040, is a medication used to treat high blood pressure. It belongs to the family of drugs known as calcium channel blockers and was developed by Bayer in 1972. Nifedipine is the first generation of this type of drug and has since been followed by second and third generation versions with longer-lasting effects. The most common third-generation calcium channel blocker is amlodipine. Nifedipine was approved by the FDA in 1981.
Procardiais the brand name
image of different drug pills on a surface
Nifedipine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Procardia
Nifedipine
1981
355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .
Angina, Stable
Helps manage Chronic Stable Angina Pectoris
Failed conventional therapy
Helps manage Failed conventional therapy
Vasospastic Angina
Helps manage Vasospastic Angina

Effectiveness

How Nifedipine Affects PatientsNifedipine helps reduce blood pressure and give the heart more oxygen. It needs to be taken three times a day, typically with a dose of 10-120mg daily. It is important to be aware of the risks associated with taking nifedipine, such as very low blood pressure, chest pain, and heart attack.
How Nifedipine works in the bodyNifedipine works by stopping calcium from entering cells in the blood vessels and heart. This reduces the pressure in the vessels and increases oxygen supply to the heart, relieving angina.

When to interrupt dosage

The proposed portion of Nifedipine is contingent upon the identified disorder, for example Achalasia, Ureteral Calculus and Hypertensive disease. The measure differs, in function of the technique of delivery (e.g. Tablet, film coated, extended release or Capsule) enumerated in the table below.
Condition
Dosage
Administration
Failed conventional therapy
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Ureteral Calculi
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Proctalgia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Angina, Stable
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Vasospastic Angina
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Edema
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Fissure in Ano
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Altitude Sickness
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Raynaud Disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive disease
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Hypertensive Emergency
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Anal sphincter hypertonia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Obstetric Labor, Premature
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Esophageal Achalasia
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral
Pulmonary Hypertension
30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Warnings

Nifedipine Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Nifedipine may interact with Pulse Frequency
There are 20 known major drug interactions with Nifedipine.
Common Nifedipine Drug Interactions
Drug Name
Risk Level
Description
Amitriptyline
Major
The metabolism of Amitriptyline can be decreased when combined with Nifedipine.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Nifedipine.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.
Nifedipine Toxicity & Overdose RiskThe lowest toxic dose of this drug in rats has been found to be 1022mg/kg and in mice is 202mg/kg. Those who overdose may experience low blood pressure, abnormal heart rate or rhythm, and fast heartbeat. Treatment may involve monitoring vital signs, raising the patient's arms and legs, and administering medications to increase blood pressure, fluids, and calcium.
image of a doctor in a lab doing drug, clinical research

Nifedipine Novel Uses: Which Conditions Have a Clinical Trial Featuring Nifedipine?

At present, 101 active trials are exploring the potential of Nifedipine to alleviate Achalasia, Hypertensive Emergency and Anal Fissure.
Condition
Clinical Trials
Trial Phases
Hypertensive disease
27 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3
Pulmonary Edema
0 Actively Recruiting
Obstetric Labor, Premature
2 Actively Recruiting
Not Applicable
Angina, Stable
0 Actively Recruiting
Esophageal Achalasia
0 Actively Recruiting
Altitude Sickness
0 Actively Recruiting
Raynaud Disease
1 Actively Recruiting
Phase 4
Pulmonary Hypertension
30 Actively Recruiting
Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1
Proctalgia
0 Actively Recruiting
Hypertensive Emergency
1 Actively Recruiting
Phase 4
Fissure in Ano
0 Actively Recruiting
Vasospastic Angina
1 Actively Recruiting
Phase 2, Phase 3
Anal sphincter hypertonia
0 Actively Recruiting
Ureteral Calculi
0 Actively Recruiting
Failed conventional therapy
0 Actively Recruiting

Nifedipine Reviews: What are patients saying about Nifedipine?

5Patient Review
11/17/2015
Nifedipine for High Blood Pressure
I switched to this treatment after 10 years of taking amlodipine, and I'm really happy with the results. My gums and legs had been swelling from the previous medication, but that's not an issue anymore.
5Patient Review
5/1/2016
Nifedipine for High Blood Pressure
This drug has been a lifesaver for me. I have chronic kidney disease, so there are a lot of blood pressure medications I can't take. When my doctor started me on this medication, my blood pressure immediately dropped into the "safe zone." I average 100-110/65-75 with this medicine, along with a few other medicines. I haven't had any side effects while taking this medicine. I would highly recommend this medication to those who have high blood pressure!
4.7Patient Review
8/20/2017
Nifedipine for High Blood Pressure
I've been on blood pressure medication since 2005 with no avail; my blood pressure would stay at a steady 170/100. However, when I went to see a doctor out of town, he prescribed me nifedipine and wow- after just 30mg a day, my BP lowered to 135/80! If I take 60mg a day, it gets even better to 117/71. Although there's a little bit of a headache that comes along with it, I'm willing to deal with it because finally my blood pressure is controllable. Perhaps there's also a cure for the headaches somewhere down the line.
3.7Patient Review
1/6/2014
Nifedipine for High Blood Pressure
I didn't see the results I wanted with this medication. My blood pressure only lowered from 180 to 160, which isn't enough. It also caused headaches, depression and fatigue. I tried taking an additional 30 mg, but the headaches got worse and I started feeling nauseous.
3.3Patient Review
4/9/2015
Nifedipine for High Blood Pressure
My daughter, who is an RN, just informed me that the symptoms I am experiencing are a severe allergic reaction to this medication. These include a severe headache, sore throat, and a rash on my torso. Be aware of these side effects and consult with your doctor if you experience them.
3Patient Review
6/1/2022
Nifedipine for High Blood Pressure
Almost immediately after starting this medication, I began experiencing a whole host of unpleasant side effects. These include: headaches, dizziness, tingling in my limbs, fatigue, and shortness of breath. If you're someone who is sensitive to medications, I would recommend steer clear of this one.
3Patient Review
10/12/2020
Nifedipine for High Blood Pressure
Nifedipine was lowering my blood pressure as intended, but the side effects were really bad. I felt terrible all the time, and my eyes were always irritated. I stopped taking it a few days ago and feel so much better already.
2.7Patient Review
4/15/2015
Nifedipine for High Blood Pressure
I didn't have a good experience with this medication. It gave me headaches and made my feet swell, only slightly lowered my numbers. I'm going to ask my doctor for something else as soon as possible.
2.7Patient Review
1/4/2014
Nifedipine for High Blood Pressure
1.7Patient Review
3/7/2018
Nifedipine for High Blood Pressure
I got a lot of unpleasant side effects from this drug, including swelling in my legs and feet, neck pain, chest pain, and vision problems. My doctor still wanted me to take it, but I refused because the side effects were too much for me to handle.
1.7Patient Review
6/25/2018
Nifedipine for High Blood Pressure
My blood pressure dropped significantly, which is great. However, I started experiencing a lot of negative side effects like heartburn, chest pain, and lethargy.
1.3Patient Review
7/24/2019
Nifedipine for High Blood Pressure
I am having a bad reaction to this medication. My bones are aching terribly and I think it might be giving me diabetes. I'll update soon after I figure out which pill is causing the problem.
1Patient Review
2/12/2019
Nifedipine for High Blood Pressure
I had a really severe reaction to this medication after only taking one dose. I was extremely hot, my blood pressure and heart rate shot up, and I had a terrible headache. When I called my doctor, they told me to double the dosage! Needless to say, I won't be taking this again.
1Patient Review
9/20/2019
Nifedipine for High Blood Pressure
Though this medication did help to lower my blood pressure, I've been experiencing some really severe headaches. My doctor says they'll eventually go away, but in the meantime, I'm just feeling really sick and uncomfortable.
1Patient Review
8/30/2017
Nifedipine for High Blood Pressure
I had a really bad headache and started vomiting.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about nifedipine

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

When should you not take nifedipine?

"Nifedipine capsules (Procardia) should not be taken immediately after a heart attack."

Answered by AI

Why is nifedipine no longer used?

"The hypertension medication nifedipine, a dihydropyridine calcium channel blocker, was once widely used but is now less so due to concerns about safety and tolerability, the introduction of new classes of hypertension medications, and data showing that other classes of medications may be more effective."

Answered by AI

What is the drug nifedipine used for?

"UK

Nifedipine is medication used to treat high blood pressure. It belongs to a class of drugs called calcium channel blockers."

Answered by AI

What are the side effects of taking nifedipine?

"Bloating or swelling in the face, arms, hands, lower legs, or feet, difficulty breathing, dizziness, fainting, a fast or irregular heartbeat, feeling hot, headaches, muscle cramps, or shaking in the legs, arms or feet."

Answered by AI

Clinical Trials for Nifedipine

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL
This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.
Waitlist Available
Has No Placebo
U Health (+1 Sites)Ziad Zoghby, M.D., M.B.A.Biobeat Technologies Ltd.
Image of UPMC Presybeterian in Pittsburgh, United States.

Telaglenastat for Pulmonary Hypertension

18 - 75
All Sexes
Pittsburgh, PA
The research study is being conducted to evaluate the effectiveness of a drug called Telaglenastat in adults diagnosed with Pulmonary Hypertension (PH). PH is a progressive condition that affects the arteries in the lungs, specifically the pulmonary arteries, which carry blood from the right side of the heart to the lungs. Telaglenastat is not currently approved by the Food and Drug Administration for the treatment of PH. However, the study investigators believe that Telaglenastat may help lower blood pressure in the lungs and improve both heart and lung function. It is important to note that the drug will not be available to participants once the study concludes.
Phase 1 & 2
Waitlist Available
UPMC PresybeterianMichael Risbano, MD
Have you considered Nifedipine clinical trials? We made a collection of clinical trials featuring Nifedipine, we think they might fit your search criteria.Go to Trials
Image of University of Alabama at Birmingham in Birmingham, United States.

Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL
Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.
Waitlist Available
Has No Placebo
University of Alabama at BirminghamPankaj Arora, MD, FAHA
Image of Brigham and Women's Hospital in Boston, United States.

Oral Treprostinil for Raynaud's Disease

18+
All Sexes
Boston, MA
Raynaud's phenomenon is a condition where the blood vessels in participants fingers and toes get too narrow when cold or stressed. This makes participants fingers and toes change colors - they might turn white, then blue, and finally red as blood flow returns. It can be painful and cause numbness or tingling. When participants have Raynaud's, blood vessels react too strongly to cold or stress. Fingers and toes may turn white (blood moves away from the area), blue (lack of oxygen), or red and feel painful or tingly when warming up. These episodes usually last from a few minutes to several hours. There are two types of Raynaud's. Primary Raynaud's (also called Raynaud's disease) itself and isn't connected to other health problems. It's the most common type and affects mostly women under 30. Secondary Raynaud's (also called Raynaud's phenomenon) is caused by other diseases like lupus, scleroderma, or rheumatoid arthritis. This type tends to be more serious and may cause painful sores on fingertips called digital ulcers. For mild cases, staying warm might be enough. But if symptoms are severe, participants doctor might prescribe various medications including calcium channel blockers - blood pressure medicines that help open blood vessels, or other vasodilators - medicines that widen blood vessels. About 40% of people with scleroderma develop painful sores on their fingertips called digital ulcers. These happen when there isn't enough blood flow to heal small injuries. For severe cases with digital ulcers, doctors might use prostacyclin therapy - medicines that mimic a natural substance that opens blood vessels. Oral treprostinil is a newer pill form of prostacyclin therapy that helps improve blood flow. The investigators are conducting a research study testing whether oral treprostinil - a pill that mimics prostacyclin (a natural blood vessel opener) - can help people with severe Raynaud's that doesn't respond to usual treatments. This represents hope for better treatment options for people with the most challenging cases of this condition.
Phase 4
Waitlist Available
Brigham and Women's HospitalAaron B Waxman, MD, PhD
Have you considered Nifedipine clinical trials? We made a collection of clinical trials featuring Nifedipine, we think they might fit your search criteria.Go to Trials
Image of University of Oklahoma health sciences Center in Oklahoma City, United States.

Neuromodulation for Pulmonary Arterial Hypertension

18 - 90
All Sexes
Oklahoma City, OK
Patients with Group 1 pulmonary hypertension will be enrolled in this study. Investigators will test the hypothesis of low-level tragal stimulation in patients with pulmonary hypertension. The study will be conducted over 4 weeks and patients will undergo low-level tragus stimulation for 1 hour every day for 4 weeks. At baseline the following tests will be conducted-6-minute walk distance, vascular function testing using noninvasive device and blood samples will be collected. Patient will also undergo a limited echocardiography to assess right ventricular function. After 4 weeks of stimulation patients will come back to undergo these tests again. Investigators hypothesized that low-level tragus stimulation (neuromodulation) will lead to improvement in vascular function, 6-minute walk distance and blood based biomarkers in patients with pulmonary hypertension.
Phase 1 & 2
Waitlist Available
University of Oklahoma health sciences CenterTarun Dasari, MD
Have you considered Nifedipine clinical trials? We made a collection of clinical trials featuring Nifedipine, we think they might fit your search criteria.Go to Trials
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