← Back to Search

Diagnostic Test

SVC Assessment for POTS

N/A
Recruiting
Led By Cyndya Shibao, M.D
Research Sponsored by Vanderbilt University Medical Center
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Between 18 and 50 years of age
If pre-menopausal women: must have regular menstrual cycle
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline up to 180 minutes post glucose challenge
Awards & highlights

Study Summary

This trial found that meals rich in carbohydrates worsened the symptoms of POTS by causing excessive blood pooling in the splanchnic circulation.

Who is the study for?
This trial is for adults aged 18-50 with Postural Tachycardia Syndrome (POTS) who experience symptoms like dizziness after meals. Participants should have a BMI of 18.5 to 29.9 and, if female and pre-menopausal, regular menstrual cycles. Exclusions include heart conditions, seizures, neuropathy, pregnancy, substance abuse, certain chronic diseases or medications.Check my eligibility
What is being tested?
The study measures the Splanchnic venous capacitance (SVC) in POTS patients compared to healthy controls to see if SVC increases more in POTS patients after eating glucose-rich foods causing worse symptoms.See study design
What are the potential side effects?
Since this trial involves measurement rather than medication or invasive procedures, side effects are minimal but may include discomfort from standing during tests or minor risks associated with non-invasive monitoring.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
Select...
I am between 18 and 50 years old.
Select...
I am a pre-menopausal woman with a regular menstrual cycle.
Select...
I have been diagnosed with POTS and feel faint after eating.
Select...
I am between 18 and 50 years old.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline up to 180 minutes post glucose challenge
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline up to 180 minutes post glucose challenge for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Syndrome
Secondary outcome measures
Measure Glucose-dependent Insulinotropic polypeptide (GIP) hormone level in POTS patients and Controls after 75 grams of glucose ingestion

Trial Design

1Treatment groups
Experimental Treatment
Group I: Splanchnic venous capacitance(SVC).Experimental Treatment1 Intervention
Splanchnic venous capacitance(SVC), the comparison between participants with POTS (Postural Tachycardia Syndrome) and Healthy Control group.

Find a Location

Who is running the clinical trial?

National Heart, Lung, and Blood Institute (NHLBI)NIH
3,819 Previous Clinical Trials
47,295,707 Total Patients Enrolled
10 Trials studying Postural Orthostatic Tachycardia Syndrome
440 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
Vanderbilt University Medical CenterLead Sponsor
853 Previous Clinical Trials
671,018 Total Patients Enrolled
16 Trials studying Postural Orthostatic Tachycardia Syndrome
859 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome
Cyndya Shibao, M.DPrincipal InvestigatorVanderbilt University Medical Center
2 Previous Clinical Trials
110 Total Patients Enrolled
2 Trials studying Postural Orthostatic Tachycardia Syndrome
110 Patients Enrolled for Postural Orthostatic Tachycardia Syndrome

Media Library

Measurement of Splanchnic venous capacitance(SVC) (Diagnostic Test) Clinical Trial Eligibility Overview. Trial Name: NCT05375968 — N/A
Postural Orthostatic Tachycardia Syndrome Research Study Groups: Splanchnic venous capacitance(SVC).
Postural Orthostatic Tachycardia Syndrome Clinical Trial 2023: Measurement of Splanchnic venous capacitance(SVC) Highlights & Side Effects. Trial Name: NCT05375968 — N/A
Measurement of Splanchnic venous capacitance(SVC) (Diagnostic Test) 2023 Treatment Timeline for Medical Study. Trial Name: NCT05375968 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is the participant demographic restricted to individuals 18 years or older?

"This clinical investigation will include patients between 18 years old and 50 years of age."

Answered by AI

May I submit an application to join this investigation?

"The requirements for acceptance into this study are a diagnosis of tachycardia and age between 18 to 50. In total, the trial is seeking 50 participants."

Answered by AI

Are there any slots available for those wishing to participate in this experiment?

"The information found on clinicaltrials.gov states that this particular medical trial is not actively recruiting at present, having been first posted on November 20th 2022 and last amended on the 6th of November. However, 1483 other research efforts are currently in search for patients to participate."

Answered by AI

Who else is applying?

What state do they live in?
Hawaii
New Mexico
Texas
How old are they?
18 - 65
What site did they apply to?
Vanderbilt University Medical Center
What portion of applicants met pre-screening criteria?
Met criteria
Did not meet criteria
Recent research and studies
~26 spots leftby Jun 2025