Eplontersen for Cardiomyopathy
Trial Summary
Will I have to stop taking my current medications?
Yes, if you are currently taking diflunisal, doxycycline, or certain calcium-channel blockers like verapamil or diltiazem, you will need to stop taking them at least 14 days before joining the trial.
What is the purpose of this trial?
To evaluate the efficacy of eplontersen compared to placebo in participants with ATTR-CM receiving available standard of care (SoC). For more information, please visit https://www.cardio-ttransform.com.
Eligibility Criteria
This trial is for adults with ATTR-CM, a type of heart disease caused by amyloid deposits. Participants must have certain heart measurements and confirmed amyloid deposits but can't be on specific heart medications, have had recent major cardiovascular events or procedures, or expect to need a heart transplant or assist device within a year.Inclusion Criteria
Exclusion Criteria
Timeline
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive subcutaneous injections of either eplontersen or placebo once every 4 weeks, along with daily supplemental doses of vitamin A
Follow-up
Participants are monitored for safety and effectiveness after treatment
Treatment Details
Interventions
- AKCEA-TTR-LRx
- Eplontersen
- Placebo
Find a Clinic Near You
Who Is Running the Clinical Trial?
Ionis Pharmaceuticals, Inc.
Lead Sponsor
Dr. Brett P. Monia
Ionis Pharmaceuticals, Inc.
Chief Executive Officer since 2020
PhD in Pharmacology from the University of Pennsylvania, BSc in Molecular Biology and Analytical Chemistry from Stockton State College
Dr. Eric Bastings
Ionis Pharmaceuticals, Inc.
Chief Medical Officer
MD