20 Participants Needed

Blood Flow Restriction Training for Parkinson's Disease

AS
AM
Overseen ByAlyssa Main
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: The University of Texas Health Science Center at San Antonio
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Blood Flow Restriction Training for Parkinson's Disease?

Research shows that blood flow restriction training combined with low-intensity resistance exercises can improve leg strength and function in people with Parkinson's disease, while also reducing symptoms of Restless Leg Syndrome. Additionally, resistance training in general has been found to enhance strength, balance, and quality of life in individuals with Parkinson's disease.12345

Is blood flow restriction training safe for people with Parkinson's Disease?

Blood flow restriction training is generally considered safe for people with neurologic conditions, with most healthcare professionals reporting no serious side effects. However, some people may find the pressure uncomfortable, and more research is needed to confirm its safety specifically for Parkinson's Disease.678910

How does blood flow restriction training differ from other treatments for Parkinson's disease?

Blood flow restriction training is unique because it combines low-intensity resistance exercises with restricted blood flow to the muscles, which can lead to strength and function improvements similar to traditional high-intensity training but with less strain on the body. This approach is novel for Parkinson's disease as it may also help reduce symptoms like Restless Leg Syndrome, improving overall quality of life.1251112

What is the purpose of this trial?

This study is being done to understand how reducing blood flow (BRT) during balance-challenging strengthening exercises (instability resistance training, or IRT) can help improve symptoms of Parkinson's disease.

Research Team

AS

Anjali Sivaramakrishnan, PhD, PT

Principal Investigator

The University of Texas Health Science Center at San Antonio

Eligibility Criteria

Inclusion Criteria

A score of ≥23 on the mini-Mental Scale Examination
My Parkinson's disease is at a moderate to advanced stage.
I am between 40-85 years old and have been diagnosed with Parkinson's Disease.

Exclusion Criteria

Ankle branchial index ≤ 0.9 or > 1.3
I have a history of heart disease or uncontrolled high blood pressure.
Absolute contraindications to exercise as per the American College of Sports Medicine (uncontrolled arrhythmias, third-degree heart block, recent electrocardiogram (EKG) changes, unstable angina, acute myocardial infarction, or acute congestive heart failure
See 7 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants will receive either Blood Flow Restriction plus Instability Resistance Training or Instability Resistance Training only, with 2 sessions per week over 6 weeks

6 weeks
12 visits (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment, including assessments of balance, mobility, and muscle strength

8 weeks

Treatment Details

Interventions

  • Blood flow restriction training
  • Instability Resistance Training
Participant Groups
2Treatment groups
Experimental Treatment
Group I: IRT Only Control GroupExperimental Treatment1 Intervention
Instability Resistance Training only group. Participants will receive 2 sessions per week over 6 weeks.
Group II: BFR plus IRT GroupExperimental Treatment2 Interventions
Blood Flow Restriction plus Instability Resistance Training group. Participants will receive 2 sessions per week over 6 weeks.

Find a Clinic Near You

Who Is Running the Clinical Trial?

The University of Texas Health Science Center at San Antonio

Lead Sponsor

Trials
486
Recruited
92,500+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Findings from Research

A study involving 35 individuals with Parkinson's disease showed that both periodized resistance training with functional exercises and traditional resistance training significantly improved functional capacity, balance, and strength over 12 weeks.
The group that included functional training specifically showed improvements in freezing of gait, while traditional resistance training led to notable improvements in motor symptoms, suggesting tailored exercise programs can effectively address different challenges faced by individuals with Parkinson's disease.
Periodized Resistance Training With and Without Functional Training Improves Functional Capacity, Balance, and Strength in Parkinson's Disease.Strand, KL., Cherup, NP., Totillo, MC., et al.[2023]
Resistance training (RT) significantly improves leg strength (SMD = 0.79) and balance capability (SMD = 0.34) in individuals with Parkinson's disease, based on a meta-analysis of 31 studies involving 1,239 participants.
RT also enhances quality of life (MD = -7.22) and shows improvements in gait performance, particularly in fast gait velocity and timed-up-and-go tests, indicating its potential as an effective rehabilitation strategy for managing motor symptoms in Parkinson's disease.
Lower Limb Resistance Training in Individuals With Parkinson's Disease: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials.Li, X., He, J., Yun, J., et al.[2020]
A 12-week progressive resistance training program significantly improved cardiac autonomic modulation in patients with Parkinson's disease, as evidenced by a notable decrease in the low-frequency component of heart rate variability.
The training also enhanced cardiovascular responses to stress tests, with the PDT group showing a greater reduction in systolic blood pressure during orthostatic stress, achieving levels comparable to healthy controls.
Effects of Progressive Resistance Training on Cardiovascular Autonomic Regulation in Patients With Parkinson Disease: A Randomized Controlled Trial.Kanegusuku, H., Silva-Batista, C., Peçanha, T., et al.[2018]

References

Periodized Resistance Training With and Without Functional Training Improves Functional Capacity, Balance, and Strength in Parkinson's Disease. [2023]
Lower Limb Resistance Training in Individuals With Parkinson's Disease: An Updated Systematic Review and Meta-Analysis of Randomized Controlled Trials. [2020]
Effects of Progressive Resistance Training on Cardiovascular Autonomic Regulation in Patients With Parkinson Disease: A Randomized Controlled Trial. [2018]
Effectiveness of resistance training on muscle strength and physical function in people with Parkinson's disease: a systematic review and meta-analysis. [2018]
Blood flow restriction resistance training in a recreationally active person with Parkinson's disease. [2022]
The Safety of Blood Flow Restriction Training as a Therapeutic Intervention for Patients With Musculoskeletal Disorders: A Systematic Review. [2020]
THE EFFECTS OF BLOOD FLOW RESTRICTION TRAINING ON FUNCTIONAL IMPROVEMENTS IN AN ACTIVE SINGLE SUBJECT WITH PARKINSON DISEASE. [2022]
Clinical use of blood flow restriction in people with neurologic conditions: a cross-sectional survey. [2022]
Hemodynamic and Hemostatic Response to Blood Flow Restriction Resistance Exercise in Coronary Artery Disease: A Pilot Randomized Controlled Trial. [2021]
Blood flow restriction training for an individual with relapsing-remitting multiple sclerosis: a case report. [2022]
Altered cardiorespiratory regulation during exercise in patients with Parkinson's disease: A challenging non-motor feature. [2020]
Functional and Brain Activation Changes Following Specialized Upper-Limb Exercise in Parkinson's Disease. [2020]
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