50 Participants Needed

Exercise Program for Parkinson's Disease

(LifePD Trial)

BJ
Overseen ByBrenda Jeng, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Illinois at Chicago
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It is best to consult with the trial coordinators or your doctor for guidance.

What data supports the effectiveness of the treatment GET Up PD for Parkinson's Disease?

Research shows that exercise programs, like Nordic walking, can improve mobility and quality of life for people with Parkinson's Disease. These benefits were observed immediately after training and persisted for months, suggesting that similar exercise treatments could be effective.12345

Is the exercise program for Parkinson's disease safe for participants?

Exercise programs for Parkinson's disease, like the SPARX trial, have been studied for safety, with concerns mainly about the risk of falls and heart-related issues in more active patients. However, these programs are generally considered safe when properly supervised and tailored to individual needs.678910

How is the GET Up PD treatment different from other treatments for Parkinson's disease?

The GET Up PD treatment is unique because it focuses on a structured exercise program specifically designed for Parkinson's disease, potentially incorporating elements like Tai Chi, resistance training, and personalized coaching, which are not typically part of standard medical treatments for this condition.1112131415

What is the purpose of this trial?

The investigators propose a Stage-I randomized controlled trial (RCT) of a remotely-delivered, 16-week social-cognitive theory-based behavioral intervention focusing on combined exercise (aerobic and resistance) training for yielding increases in device-measured physical activity and improvements in cognitive function, symptoms, and quality of life (QOL), and social-cognitive theory (SCT) outcomes among physically inactive persons with Parkinson's disease (PD). Participants (N=50) will be randomly assigned into exercise training (combined aerobic and resistance exercise) condition or active control (flexibility and stretching) condition. The 16-week intervention will be delivered and monitored remotely within a participant\'s home/community and supported by Zoom-based chats guided by SCT via a behavioral coach. Participants will receive training materials (e.g., prescriptive manual and exercise equipment), one-on-one coaching, action-planning via calendars, self-monitoring via logs, and SCT-based newsletters. The investigators hypothesize that the home-based exercise intervention will yield improvements in cognitive, symptomatic, and QOL outcomes.

Research Team

Motl, Robert | College of Applied ...

Robert Motl, Ph.D

Principal Investigator

University of Illinois at Chicago

Eligibility Criteria

This trial is for physically inactive individuals with Parkinson's Disease who are interested in improving their physical activity, cognitive function, symptoms, and quality of life. Participants will engage in a 16-week program from home using Zoom and must be willing to follow the exercise or stretching routines provided.

Inclusion Criteria

English as a primary language
Confirmed diagnosis of PD
Internet and email access
See 5 more

Exclusion Criteria

Severe cognitive impairment based on a modified Telephone Interview for Cognitive Status (TICS-M) score of less than 18
Above inclusion criteria not met
Moderate or high risk of contraindications for possible injury or death when undertaking strenuous or maximal exercise using the PAR-Q
See 1 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 16-week remotely-delivered, social-cognitive theory-based behavioral intervention focusing on combined exercise (aerobic and resistance) training or active control (flexibility and stretching) condition.

16 weeks
Remote sessions via Zoom

Follow-up

Participants are monitored for changes in cognitive function, symptoms, and quality of life after the intervention.

4 weeks

Treatment Details

Interventions

  • GET Up PD
Trial Overview The study tests a social-cognitive theory-based behavioral intervention that includes aerobic and resistance exercises (GET Up PD) against an active control group doing flexibility and stretching. It aims to see if the exercise training can improve physical activity levels, cognitive functions, symptoms, and quality of life over 16 weeks.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: GET Up PDExperimental Treatment1 Intervention
Remotely-coached/guided, home-based program delivered using telerehabilitation focusing on aerobic fitness and muscle strength as a mode of training
Group II: Stretching and FlexibilityActive Control1 Intervention
Remotely-coached/guided, home-based program delivered using telerehabilitation focusing on stretching and range of motion as the mode of training

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Illinois at Chicago

Lead Sponsor

Trials
653
Recruited
1,574,000+

National Institute on Aging (NIA)

Collaborator

Trials
1,841
Recruited
28,150,000+

Findings from Research

A 6-month community exercise program for people with Parkinson's disease was found to be safe, with high adherence rates (37 out of 53 participants) and no serious adverse events related to the exercise.
The exercise group showed positive effects on motor symptoms, with a small effect size for improvements in walking distance and overall motor function, suggesting potential long-term benefits of regular exercise for this population.
Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease.Collett, J., Franssen, M., Meaney, A., et al.[2021]
A survey of 64 Parkinson's Disease patients revealed that 67% exercised at least twice a week, with walking being the most common form of exercise, and 97% reported improvements in their symptoms due to exercise.
Patients who exercised in groups experienced greater symptomatic improvements compared to those who exercised alone, highlighting the potential added benefits of social interaction and cognitive engagement in group activities like dance therapy.
Self-Reported Exercise Trends in Parkinson's Disease Patients.Raje, P., Ning, S., Branson, C., et al.[2019]
In a 16-month study involving 121 individuals with Parkinson's disease, the flexibility/balance/function exercise (FBF) program showed significant improvements in overall physical function compared to a home-based control group at 4 months.
The supervised aerobic exercise (AE) program demonstrated better walking economy than the FBF program at multiple time points (4, 10, and 16 months), indicating its effectiveness in enhancing physical performance in individuals with Parkinson's disease.
Exercise for people in early- or mid-stage Parkinson disease: a 16-month randomized controlled trial.Schenkman, M., Hall, DA., Barón, AE., et al.[2022]

References

Phase II randomised controlled trial of a 6-month self-managed community exercise programme for people with Parkinson's disease. [2021]
The effects of balance training and high-intensity resistance training on persons with idiopathic Parkinson's disease. [2022]
Self-Reported Exercise Trends in Parkinson's Disease Patients. [2019]
Exercise for people in early- or mid-stage Parkinson disease: a 16-month randomized controlled trial. [2022]
Nordic walking improves mobility in Parkinson's disease. [2022]
The meaning of regular participation in vigorous-intensity exercise among men with Parkinson's disease. [2022]
How might physical activity benefit patients with Parkinson disease? [2022]
Implementation of a Community-Based Exercise Program for Parkinson Patients: Using Boxing as an Example. [2020]
Study in Parkinson disease of exercise (SPARX): translating high-intensity exercise from animals to humans. [2021]
A long-term community gym program for people with Parkinson's disease: a feasibility study of the Monash Health "Health and Fitness" model. [2023]
11.Korea (South)pubmed.ncbi.nlm.nih.gov
The Efficacy of Exercise Programs for Parkinson's Disease: Tai Chi versus Combined Exercise. [2021]
[Implementation of an individualized tablet-based training program in the domestic setting following complex treatment of Parkinson's disease-Success factors and barriers]. [2022]
13.United Statespubmed.ncbi.nlm.nih.gov
Effects of moderate-volume, high-load lower-body resistance training on strength and function in persons with Parkinson's disease: a pilot study. [2021]
14.United Statespubmed.ncbi.nlm.nih.gov
Promoting Physical Activity via Telehealth in People With Parkinson Disease: The Path Forward After the COVID-19 Pandemic? [2020]
Samba, deep water, and poles: a framework for exercise prescription in Parkinson's disease. [2022]
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top
Terms of Service·Privacy Policy·Cookies·Security