Understanding Episodic Memory in Epilepsy
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to explore how the brain manages learning, memory, and decision-making. Researchers seek to understand these processes better to eventually design treatments for learning and memory disorders. The trial uses specialized equipment, such as the Adtech Behnke-Fried micro-electrodes and the Blackrock Cerestim stimulator, to monitor brain activity during simple tasks. People with hard-to-control epilepsy who are already undergoing brain monitoring might be suitable candidates, especially if they can press buttons on a laptop to answer questions. As an unphased trial, participants can contribute to groundbreaking research that may lead to future treatments.
Will I have to stop taking my current medications?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.
What prior data suggests that these devices are safe for use in this study?
Previous studies have shown that Adtech Behnke-Fried micro-electrodes carry a very low risk of serious complications. For instance, one study found that only 0.4% of electrodes caused serious issues, with no infections or deaths reported, indicating general safety for brain monitoring.
Human studies have thoroughly tested the Blackrock Cerestim stimulator. It provides safe electrical stimulation, adhering to guidelines that maintain safe levels.
Researchers often use the Cedrus RB-844 response pad to record responses during tests. It poses no direct risks to users, as it serves as a data collection tool rather than a treatment device.
The Neurolynx electrophysiology system records brain activity and is a standard, safe tool for data gathering in research.
Overall, various studies have tested each of these tools for safety, and they are regularly used in research. This ensures they are well-tolerated and safe for participants in clinical trials.12345Why are researchers excited about this trial?
Researchers are excited about this trial because it's exploring new ways to understand how epilepsy affects memory. Unlike traditional treatments that mainly focus on controlling seizures with medication, this study uses advanced technology like micro-electrodes and brain stimulators to record and analyze brain activity in real time. By diving deep into how neuronal signals relate to memory, researchers hope to uncover insights that could lead to more targeted therapies in the future. This approach is unique because it aims not just to treat symptoms but to understand the underlying brain processes, potentially paving the way for breakthroughs in managing memory issues in epilepsy patients.
What evidence suggests that these devices are effective for understanding episodic memory in epilepsy?
Research has shown that Adtech Behnke-Fried micro-electrodes, used in this trial, can test memory processes in people with epilepsy. These tiny devices measure brain activity with high accuracy, crucial for understanding memory function. Studies also indicate that the Blackrock Cerestim stimulator, another tool in this trial, can enhance memory by delivering small electrical pulses to specific brain regions. This stimulation has been shown to boost memory performance. The Cedrus RB-844 response pad records answers during memory tasks, aiding in the precise collection of data on memory function. Finally, the Neurolynx electrophysiology system monitors brain activity to study communication between brain areas during memory tasks, helping researchers learn more about memory operations in the brain.36789
Who Is on the Research Team?
Adam Mamelak, MD
Principal Investigator
Cedars-Sinai Medical Center
Ueli Rutishauser, PhD
Principal Investigator
Cedars-Sinai Medical Center
Are You a Good Fit for This Trial?
This trial is for individuals aged 13 or older with intractable epilepsy who are already undergoing invasive monitoring. Participants should have an IQ over 70 and be able to understand and perform tasks on a computer by pressing buttons. Those unable to complete the tasks due to cognitive, psychological limits, or pain cannot join.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Behavioral Testing
Participants undergo behavioral and neuronal recordings to assess memory strength and decision-making processes
Follow-up
Participants are monitored for safety and effectiveness after the main experimental procedures
What Are the Treatments Tested in This Trial?
Interventions
- Adtech Behnke-Fried micro-electrodes
- Blackrock Cerestim stimulator
- Cedrus RB-844 response pad
- Neurolynx electrophysiology system
Find a Clinic Near You
Who Is Running the Clinical Trial?
Cedars-Sinai Medical Center
Lead Sponsor
California Institute of Technology
Collaborator
Johns Hopkins University
Collaborator
University of Colorado, Denver
Collaborator
University Health Network, Toronto
Collaborator
Boston Children's Hospital
Collaborator
University of California, Santa Barbara
Collaborator
National Institute of Neurological Disorders and Stroke (NINDS)
Collaborator
National Institutes of Health (NIH)
Collaborator