39 Participants Needed

Interval Training for Parkinson's Disease

Recruiting at 1 trial location
JF
KJ
Overseen ByKylie J. Martinez, MS
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: University of Miami
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Do I have to stop taking my current medications for the trial?

The trial protocol does not specify whether you need to stop taking your current medications.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the idea that Interval Training for Parkinson's Disease is an effective treatment?

The available research shows that high-intensity interval training (HIIT) is a feasible and effective exercise option for people with Parkinson's Disease. It suggests that HIIT can help improve motor symptoms and slow their progression. Compared to other exercise types like resistance training and endurance training, HIIT is considered safe and beneficial. Resistance training improves muscle strength and quality of life, while endurance training enhances fitness and mobility. Overall, these exercise methods, including HIIT, are valuable for managing Parkinson's Disease symptoms.12345

What data supports the effectiveness of the treatment High-Intensity Interval Training for Parkinson's Disease?

Research shows that high-intensity interval training (HIIT) is a feasible and effective exercise for people with Parkinson's, helping to improve symptoms like balance and muscle strength. Studies also suggest that similar intensive exercises, like resistance and endurance training, can enhance functional outcomes and quality of life for those with Parkinson's.12345

What safety data exists for interval training in Parkinson's disease?

The safety of high-intensity interval training (HIIT) and other intensive exercise modalities for Parkinson's disease (PD) has been evaluated in several studies. A high-intensity exercise boot camp was found to be feasible and safe for individuals with PD. A systematic review and meta-analysis concluded that resistance training (RT), endurance training (ET), and other intensive exercise modalities (OITM) are safe and feasible, without worsening PD symptoms. Additionally, sprint exercise and high-intensity interval cycle ergometer training have been studied for feasibility and safety, with positive findings. Overall, these studies suggest that high-intensity interval training and similar exercises are safe for people with Parkinson's disease.36789

Is interval training safe for people with Parkinson's disease?

Research shows that high-intensity interval training (HIIT) and other intensive exercise programs are generally safe for people with Parkinson's disease. These exercises do not worsen symptoms and may even improve balance and mood.36789

Is High-Intensity Interval Training a promising treatment for Parkinson's Disease?

Yes, High-Intensity Interval Training (HIIT) is a promising treatment for Parkinson's Disease. It can help reduce inflammation, improve learning and memory, and lower the risk of heart disease. HIIT is also effective in managing motor symptoms and enhancing overall quality of life for people with Parkinson's.12379

How does the treatment 'Interval Training for Parkinson's Disease' differ from other treatments for this condition?

Interval training, specifically high-intensity interval training (HIIT), is unique for Parkinson's disease as it not only helps with motor symptoms but also promotes neuroplasticity (the brain's ability to reorganize itself) and reduces inflammation, which are not typically addressed by standard treatments. Unlike medications that mainly manage symptoms, HIIT offers a potential disease-modifying effect by improving brain health and function.12379

What is the purpose of this trial?

This research is designed to compare the impact of high-intensity interval training and high-velocity circuit resistance training on heart rate variability, gait, and functional performance in patients with Parkinsons disease.

Research Team

JF

Joseph F. Signorile, PhD

Principal Investigator

University of Miami

Eligibility Criteria

This trial is for individuals with Parkinson's Disease, specifically those who have issues with their autonomic nervous system. The exact eligibility criteria are not provided, but typically participants should be medically stable to engage in physical training.

Inclusion Criteria

I am between 30 and 90 years old.
My Parkinson's symptoms are mild, as assessed within the last year.
I have been diagnosed with Parkinson's disease.

Exclusion Criteria

Having a pacemaker or other internal medical devices
I have HIV or another immune system condition.
I have a neuromuscular condition that is not Parkinson's disease.
See 2 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants receive either high-intensity interval training or high-velocity circuit resistance training 2 times per week for 10 consecutive weeks

10 weeks

Follow-up

Participants are monitored for changes in heart rate variability, gait, and functional performance

4 weeks

Treatment Details

Interventions

  • High-Intensity Interval Training
  • High-Velocity Circuit Resistance Training
Trial Overview The study compares two exercise approaches: high-intensity interval training (short bursts of intense exercise) and high-velocity circuit resistance training (strength exercises at a fast pace), focusing on their effects on heart rate variability, walking ability, and overall function.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: High-Intensity Interval TrainingExperimental Treatment1 Intervention
Participants in this group will receive high-intensity interval training 2 times per week for 10 consecutive weeks.
Group II: High-Velocity Circuit Resistance TrainingActive Control1 Intervention
Participants in this group will receive high-velocity circuit resistance training 2 times per week for 10 consecutive weeks.

Find a Clinic Near You

Who Is Running the Clinical Trial?

University of Miami

Lead Sponsor

Trials
976
Recruited
423,000+

Findings from Research

High-intensity interval training (HIIT) has been shown to significantly improve disease severity and quality of life in individuals with Parkinson's disease, based on a systematic review of 15 randomized clinical trials involving 654 participants.
While HIIT demonstrated benefits in motor function and functional mobility compared to control groups, the evidence comparing HIIT to moderate intensity exercise remains limited and shows variability among studies.
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis.Sena, IG., Costa, AVD., Santos, IKD., et al.[2023]
High-intensity interval training (HIIT) is feasible and safe for people with mild-to-moderate Parkinson's disease, with 90-100% program completion reported in studies lasting up to 12 weeks.
HIIT significantly improves cardiorespiratory fitness (VO2peak/max) and may enhance brain-derived neurotrophic factor (BDNF) levels and motor symptoms, although it did not show superior effects compared to moderate-intensity continuous exercise.
The feasibility, safety, physiological and clinical effects of high-intensity interval training for people with Parkinson's: a systematic review and meta-analysis.Harpham, C., Gunn, H., Marsden, J., et al.[2023]
Resistance training (RT) and endurance training (ET) are safe and feasible exercise modalities for people with Parkinson's disease, showing significant benefits in muscle strength, functional capacity, and quality of life based on a review of 33 new randomized controlled trials.
RT demonstrated a strong positive impact on muscle strength (SMD = 0.83) and functional capacity, while ET improved cardiorespiratory fitness (SMD = 0.27) and also showed potential benefits for functional outcomes, indicating that both types of exercise can be effective adjunct therapies for managing Parkinson's disease.
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis.Gamborg, M., Hvid, LG., Dalgas, U., et al.[2022]

References

Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis. [2023]
The feasibility, safety, physiological and clinical effects of high-intensity interval training for people with Parkinson's: a systematic review and meta-analysis. [2023]
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis. [2022]
FIGHT-PD: A feasibility study of periodized boxing training for Parkinson disease. [2023]
Study in Parkinson's disease of exercise phase 3 (SPARX3): study protocol for a randomized controlled trial. [2023]
A High-Intensity Exercise Boot Camp for Persons With Parkinson Disease: A Phase II, Pragmatic, Randomized Clinical Trial of Feasibility, Safety, Signal of Efficacy, and Disease Mechanisms. [2022]
High-intensity interval training modulates inflammatory response in Parkinson's disease. [2022]
Sprint exercise for subjects with mild-to-moderate Parkinson's disease: Feasibility and biomechanical outputs. [2021]
High-Intensity Interval Cycle Ergometer Training in Parkinson's Disease: Protocol for Identifying Individual Response Patterns Using a Single-Subject Research Design. [2020]
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