30 Participants Needed

HIIT Programs for Cardiac Rehabilitation

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AR
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Overseen ByJenna-Lee Taylor, PhD
Age: 18+
Sex: Any
Trial Phase: Academic
Sponsor: Mayo Clinic
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

What is the purpose of this trial?

The purpose of the study is to examine the effect of two different high intensity interval training (HIIT) prescription approaches on improving fitness, heart function, and the ability of the body's muscles to receive oxygen.

Will I have to stop taking my current medications?

The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial coordinators or your doctor.

What data supports the effectiveness of the treatment Constant High Intensity Interval Training (CON-HIIT) and Progressive High Intensity Interval Training (PRO-HIIT) for cardiac rehabilitation?

Research shows that high-intensity interval training (HIIT) is a safe and effective alternative to moderate-intensity continuous training for improving heart health in older patients with cardiovascular disease. Studies have found that HIIT can lead to greater improvements in cardiorespiratory fitness compared to moderate-intensity training.12345

Is high-intensity interval training (HIIT) safe for cardiac rehabilitation?

Research shows that HIIT is generally safe for cardiac rehabilitation, with a low rate of major adverse cardiovascular events. In a study of 1117 participants, only one major cardiovascular event occurred per 17,083 training sessions, and minor events were mostly musculoskeletal complaints.34678

How does the HIIT treatment for cardiac rehabilitation differ from other treatments?

The HIIT treatment for cardiac rehabilitation is unique because it involves short bursts of high-intensity exercise followed by rest, which can improve heart and lung fitness more effectively than traditional continuous exercise. This approach is still being studied to determine the best way to use it for heart conditions like coronary artery disease and heart failure.248910

Research Team

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Amanda R Bonikowske, PhD

Principal Investigator

Mayo Clinic

Eligibility Criteria

This trial is for adults over 18 who speak English and can consent to participate. It's specifically for those with certain heart conditions like acute coronary syndrome or stable angina, who are recommended non-surgical cardiac rehab. People post-heart surgery, with heart devices, or unable to do structured exercise aren't eligible.

Inclusion Criteria

I need heart rehab for a condition that didn't require surgery.
Able to provide consent
English speaking
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Exclusion Criteria

Patients who are unable to engage in a regularly structured exercise training program as part of a clinically indicated center-based outpatient cardiac rehabilitation program are not eligible
I was referred to cardiac rehab after heart surgery or because I have a ventricular assist device.
Patients unable/unwilling to provide informed consent will not be enrolled
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Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Treatment

Participants undergo a 12-week high-intensity interval training (HIIT) program with either progressive or standard-care interval training approaches

12 weeks
Weekly sessions

Follow-up

Participants are monitored for changes in cardiorepiratory fitness, oxygen uptake, and other health metrics

4 weeks

Treatment Details

Interventions

  • Constant High Intensity Interval Training (CON-HIIT)
  • Progressive High Intensity Interval Training (PRO-HIIT)
Trial OverviewThe study compares two types of high-intensity interval training (HIIT) in cardiac rehab: Constant HIIT (CON-HIIT) and Progressive HIIT (PRO-HIIT). The goal is to see which one better improves fitness levels, heart function, and muscle oxygen uptake.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Progressive interval-training groupExperimental Treatment1 Intervention
Subjects will complete an interval-training program during which the number of intervals and the duration of each interval are changed across the 12-week cardiac rehabilitation program.
Group II: Standard-care interval-training groupActive Control1 Intervention
Subjects will complete a standard interval-training program that remains constant for the entire 12 weeks of cardiac rehabilitation.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Mayo Clinic

Lead Sponsor

Trials
3,427
Recruited
3,221,000+

Findings from Research

In a study of 238 patients undergoing cardiac rehabilitation after acute coronary syndrome, exercise intensity significantly increased over 8 weeks, indicating improved functional capacity.
Patients experienced lower perceived exertion and heart rates at higher exercise intensities, suggesting that they could handle more intense workouts without feeling as fatigued, which is beneficial for their recovery.
Progression of aerobic exercise intensity in a cardiac rehabilitation program.Amorim, H., Cadilha, R., Parada, F., et al.[2021]
Higher-intensity interval training (HIIT) was safely integrated into a standard cardiac rehabilitation program for 39 patients, with no hospitalizations reported during or after exercise, indicating its safety for patients with stable coronary heart disease.
HIIT led to a significantly greater improvement in peak oxygen uptake (3.6 mLยทkgโปยนยทminโปยน) compared to moderate-intensity continuous training (1.7 mLยทkgโปยนยทminโปยน), demonstrating its efficacy in enhancing cardiorespiratory fitness.
Greater improvement in cardiorespiratory fitness using higher-intensity interval training in the standard cardiac rehabilitation setting.Keteyian, SJ., Hibner, BA., Bronsteen, K., et al.[2022]
In a study of 81 heart disease patients with very high cardiovascular risk, both moderate and high-intensity interval training (MIIT and HIIT) were found to be safe, with no adverse outcomes reported during the training.
While there were no statistically significant differences in overall exercise improvements between the training types, the HIIT group showed a trend towards greater improvements in exercise tolerance, suggesting it may be more effective than continuous moderate intensity training (MICT).
Safety and improvement in exercise tolerance with interval training vs moderate-intensity continuous training in heart disease patient of very high cardiovascular risk.Pineda-Garcรญa, AD., Lara-Vargas, JA., Ku-Gonzรกlez, A., et al.[2022]

References

Progression of aerobic exercise intensity in a cardiac rehabilitation program. [2021]
Greater improvement in cardiorespiratory fitness using higher-intensity interval training in the standard cardiac rehabilitation setting. [2022]
Safety and improvement in exercise tolerance with interval training vs moderate-intensity continuous training in heart disease patient of very high cardiovascular risk. [2022]
Low-volume high-intensity interval training vs continuous aerobic cycling in patients with chronic heart failure: a pragmatic randomised clinical trial of feasibility and effectiveness. [2022]
High-Intensity Interval Training in Cardiac Rehabilitation. [2020]
High-Intensity Interval Training for Patients With Cardiovascular Disease-Is It Safe? A Systematic Review. [2021]
High-Intensity Interval Training in Older Adults: a Scoping Review. [2021]
Effects of high-intensity interval training on trajectories of gas-exchange measures and blood lactate concentrations during cardiopulmonary exercise tests in cardiac rehabilitation-A randomized controlled trial. [2023]
High-intensity Interval Training Dosage for Heart Failure and Coronary Artery Disease Cardiac Rehabilitation. A Systematic Review and Meta-analysis. [2019]
High-intensity interval training in cardiac rehabilitation: a multi-centre randomized controlled trial. [2023]