64 Participants Needed

High-Intensity Interval Training for Parkinson's Disease

(PD HIIT Trial)

TB
RW
Overseen ByRon Walser, PT, DPT
Age: Any Age
Sex: Any
Trial Phase: Academic
Sponsor: Pacific Northwest University of Health Sciences
No Placebo GroupAll trial participants will receive the active study treatment (no placebo)

Trial Summary

Will I have to stop taking my current medications?

The trial does not specify if you need to stop taking your current medications, but it mentions that a major change in medication during the study period is not allowed. It's best to discuss your current medications with the study team.

What data supports the effectiveness of the treatment High-Intensity Interval Training for Parkinson's Disease?

Research suggests that high-intensity interval training (HIIT) is a promising treatment for Parkinson's disease, as it may help improve motor symptoms and promote neuroplasticity (the brain's ability to reorganize itself). Studies have shown that similar high-intensity exercises can enhance muscle strength, balance, and quality of life in people with Parkinson's.12345

Is high-intensity interval training safe for people with Parkinson's disease?

Research shows that high-intensity interval training (HIIT) is generally safe for people with Parkinson's disease and does not worsen symptoms. It can also have positive effects on balance, muscle strength, and overall quality of life.23567

How is high-intensity interval training different from other treatments for Parkinson's disease?

High-intensity interval training (HIIT) is unique for Parkinson's disease as it not only helps improve motor symptoms but also promotes neuroplasticity (the brain's ability to adapt) and reduces inflammation, which are not typically addressed by standard drug treatments. Unlike continuous exercise, HIIT involves short bursts of intense activity, which may lead to quicker improvements in both motor and cognitive functions.12378

What is the purpose of this trial?

The goal of the study is to compare different types of high intensity circuit exercises over an 8-class training series in people with Parkinson disease. The main question it aims to answer is:-Does including arm and hand exercises with leg exercises improve reaction time, balance, functional measures, gait speed and quality of life? This group will be compared to a group that only does leg exercises. Participants will be asked to participate in 8 high intensity circuit exercise classes.

Research Team

TB

Tiffany B Salido, DPT, PhD

Principal Investigator

Pacific Northwest University of Health Sciences

Eligibility Criteria

This trial is for individuals with Parkinson's Disease who are interested in participating in an exercise program. The study will include people willing to complete 8 high-intensity circuit training classes focusing on different body parts.

Inclusion Criteria

I can walk on my own, with or without help from a device.
I have been cleared by a doctor to do moderate or hard exercise.
I have been diagnosed with Parkinson's disease.
See 1 more

Exclusion Criteria

I haven't changed my medications significantly during the study period.
I have unstable bones or severe osteoporosis.
I have a muscle or ligament tear.
See 4 more

Timeline

Screening

Participants are screened for eligibility to participate in the trial

2-4 weeks

Baseline Assessment

Baseline assessment includes demographics, disease and fall history, and outcome measure collection

1 week
1 visit (in-person)

Treatment

Participants engage in 8 high intensity circuit exercise classes focusing on lower and/or upper extremity training

8 weeks
8 visits (in-person)

Post-intervention Assessment

Post-intervention balance and stepping outcomes are reassessed

1 week
1 visit (in-person)

Follow-up

Participants are monitored for safety and effectiveness after treatment

8-10 weeks

Treatment Details

Interventions

  • High-intensity Interval Circuit Training
Trial Overview The study tests whether a combination of arm and hand exercises with leg exercises can improve reaction time, balance, functional measures, gait speed, and quality of life compared to just leg exercises.
Participant Groups
2Treatment groups
Experimental Treatment
Active Control
Group I: Lower extremity and upper extremity exerciseExperimental Treatment1 Intervention
Exercises in the circuit (8 total) will focus on the lower extremity (4) and upper extremity (4)
Group II: Lower extremity exerciseActive Control1 Intervention
Exercises in the circuit (8 total) will focus on the lower extremity (4) alone.

Find a Clinic Near You

Who Is Running the Clinical Trial?

Pacific Northwest University of Health Sciences

Lead Sponsor

Trials
11
Recruited
2,200+

Findings from Research

A study involving four participants with Parkinson's disease compared the effects of 4 weeks of high-intensity interval training (HIIT) to continuous aerobic exercise, aiming to assess improvements in both motor and non-motor symptoms.
The research also aimed to explore the relationship between exercise types and changes in blood biomarkers related to neuroplasticity and neurodegeneration, which could provide insights into potential disease-modifying effects of HIIT.
High-Intensity Interval Cycle Ergometer Training in Parkinson's Disease: Protocol for Identifying Individual Response Patterns Using a Single-Subject Research Design.van Wegen, EEH., Hirsch, MA., van de Berg, WDJ., et al.[2020]
Resistance training (RT) and endurance training (ET) are safe and feasible exercise modalities for people with Parkinson's disease, showing significant benefits in muscle strength, functional capacity, and quality of life based on a review of 33 new randomized controlled trials.
RT demonstrated a strong positive impact on muscle strength (SMD = 0.83) and functional capacity, while ET improved cardiorespiratory fitness (SMD = 0.27) and also showed potential benefits for functional outcomes, indicating that both types of exercise can be effective adjunct therapies for managing Parkinson's disease.
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis.Gamborg, M., Hvid, LG., Dalgas, U., et al.[2022]
High-intensity interval training (HIIT) has been shown to significantly improve disease severity and quality of life in individuals with Parkinson's disease, based on a systematic review of 15 randomized clinical trials involving 654 participants.
While HIIT demonstrated benefits in motor function and functional mobility compared to control groups, the evidence comparing HIIT to moderate intensity exercise remains limited and shows variability among studies.
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis.Sena, IG., Costa, AVD., Santos, IKD., et al.[2023]

References

High-Intensity Interval Cycle Ergometer Training in Parkinson's Disease: Protocol for Identifying Individual Response Patterns Using a Single-Subject Research Design. [2020]
Parkinson's disease and intensive exercise therapy - An updated systematic review and meta-analysis. [2022]
Feasibility and effect of high-intensity training on the progression of motor symptoms in adult individuals with Parkinson's disease: A systematic review and meta-analysis. [2023]
The feasibility, safety, physiological and clinical effects of high-intensity interval training for people with Parkinson's: a systematic review and meta-analysis. [2023]
A High-Intensity Exercise Boot Camp for Persons With Parkinson Disease: A Phase II, Pragmatic, Randomized Clinical Trial of Feasibility, Safety, Signal of Efficacy, and Disease Mechanisms. [2022]
FIGHT-PD: A feasibility study of periodized boxing training for Parkinson disease. [2023]
High-intensity interval training modulates inflammatory response in Parkinson's disease. [2022]
Differential Acute Effect of High-Intensity Interval or Continuous Moderate Exercise on Cognition in Individuals With Parkinson's Disease. [2020]
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