Adalat

Anal sphincter hypertonia, Proctalgia, Altitude Sickness + 12 more

Treatment

3 FDA approvals

20 Active Studies for Adalat

What is Adalat

Nifedipine

The Generic name of this drug

Treatment Summary

Nifedipine (brand name BAY a 1040) is a type of medication used to treat high blood pressure. It belongs to a class of drugs known as calcium channel blockers and is the first of its kind to be developed. Nifedipine works by blocking calcium from entering the cells in the walls of arteries, which reduces tension and widens them. This helps to lower blood pressure and improve blood flow. There are newer, second and third generation versions of nifedipine with slower onset times and longer-lasting effects, such as amlodipine. Nifedipine was approved by

Procardia

is the brand name

image of different drug pills on a surface

Adalat Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procardia

Nifedipine

1981

355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Angina, Stable and Failed conventional therapy .

Angina, Stable

Helps manage Chronic Stable Angina Pectoris

Failed conventional therapy

Helps manage Failed conventional therapy

Vasospastic Angina

Helps manage Vasospastic Angina

Effectiveness

How Adalat Affects Patients

Nifedipine is a medication that helps to lower blood pressure and increase the amount of oxygen that reaches the heart. It needs to be taken three times a day, typically in doses of 10 to 120mg daily. It is important for patients to be aware of the risks associated with taking this medication, such as excessively low blood pressure, chest pain and heart attack.

How Adalat works in the body

Nifedipine helps reduce blood pressure and ease chest pain by blocking the entry of calcium ions into cells. This stops the cells from becoming over-stimulated, allowing blood vessels to relax and provide more oxygen to the heart.

When to interrupt dosage

The suggested dose of Adalat is contingent upon the diagnosed condition, including Achalasia, Ureteral Calculus and Hypertensive disease. The amount of dosage varies, as per the method of delivery (e.g. Tablet, film coated, extended release or Capsule) specified in the table below.

Condition

Dosage

Administration

Ureteral Calculi

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Angina, Stable

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Fissure in Ano

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Vasospastic Angina

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Failed conventional therapy

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Proctalgia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Edema

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Altitude Sickness

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Raynaud Disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Hypertensive Emergency

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Anal sphincter hypertonia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Obstetric Labor, Premature

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Esophageal Achalasia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Pulmonary Hypertension

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

Tablet, film coated, extended release, Oral, , Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule - Oral, Capsule, Tablet, Tablet - Oral, Tablet, film coated - Oral, Tablet, film coated, Kit; Tablet, delayed release; Tablet, extended release - Oral, Kit; Tablet, delayed release; Tablet, extended release

Warnings

Adalat has one contraindication, thus its use should be avoided if any of the situations in the table below are present.

Adalat Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nifedipine may interact with Pulse Frequency

There are 20 known major drug interactions with Adalat.

Common Adalat Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Nifedipine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Nifedipine.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.

Adalat Toxicity & Overdose Risk

The lowest toxic dose of the drug in rats was found to be 1022mg/kg and in mice was 202mg/kg. An overdose on this drug may cause low blood pressure, problems with the heart rate, and rapid heartbeat. Treatment for an overdose should involve monitoring vital signs, raising the patient's extremities, and administering fluids, vasopressors, and calcium.

image of a doctor in a lab doing drug, clinical research

Adalat Novel Uses: Which Conditions Have a Clinical Trial Featuring Adalat?

101 active investigations are exploring the potential of Adalat to mitigate Achalasia, Hypertensive Emergency and Anal Fissures.

Condition

Clinical Trials

Trial Phases

Obstetric Labor, Premature

2 Actively Recruiting

Not Applicable

Pulmonary Edema

0 Actively Recruiting

Hypertensive disease

27 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Angina, Stable

0 Actively Recruiting

Esophageal Achalasia

0 Actively Recruiting

Altitude Sickness

0 Actively Recruiting

Raynaud Disease

1 Actively Recruiting

Phase 4

Pulmonary Hypertension

33 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Proctalgia

0 Actively Recruiting

Hypertensive Emergency

1 Actively Recruiting

Phase 4

Fissure in Ano

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Anal sphincter hypertonia

0 Actively Recruiting

Ureteral Calculi

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

Adalat Reviews: What are patients saying about Adalat?

5

Patient Review

11/13/2007

Adalat for Angina

3

Patient Review

1/16/2008

Adalat for Angina

My blood pressure and chest pain are much more manageable now.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adalat

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is nifedipine and Adalat the same thing?

"Nifedipine is available as an oral tablet in the brand-name drugs Adalat CC, Afeditab CR, and Procardia XL. These are all extended-release tablets, meaning the drug is slowly released into your bloodstream over time."

Answered by AI

When do you give Adalat?

"It is recommended that you take Adalat CC once a day on an empty stomach. Adalat CC is an extended release dosage form, which means you should swallow the tablet whole, without biting or dividing it. In general, you should start with 30 mg once a day, and increase the dosage over a 7-14 day period."

Answered by AI

Is Adalat for blood pressure?

"Nifedipine, sold under the brand name Adalat, is a calcium channel blocker used to lower high blood pressure and treat chest pain. Nifedipine slows the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels, lowers blood pressure, and makes it easier for the heart to pump."

Answered by AI

What is Adalat used for?

"This medication prevents certain types of chest pain by blocking calcium channels. This allows the individual to exercise more and have fewer angina attacks."

Answered by AI

Clinical Trials for Adalat

Image of Miles Square Health Center Chicago in Chicago, United States.

Food is Medicine for High Blood Pressure and Obesity

Any Age
All Sexes
Chicago, IL

The goal of this clinical trial is to treat both hypertension and obesity in adults using a food is medicine framework. Participants will be randomized 1:1 to FIM+DASH or usual-care control. The 24-week trial includes a 12-week FIM+DASH intervention followed by a 12-week maintenance period and leverages existing partnerships with community-based organizations for home food delivery and culinary skill-skill building. The main questions it aims to answer are: (1) What is the effect of FIM+DASH vs. usual care control on blood pressure? (2) What is the effect of FIM+DASH vs. usual care control on DASH diet adherence (diet quality), body weight, and waist circumference? (3) How to identify factors associated with the sustainability and scalability of FIM+DASH in real-world settings?

Phase 2
Waitlist Available

Miles Square Health Center Chicago (+3 Sites)

Image of U Health in Miami, United States.

Cuffless PPG Monitor for High Blood Pressure

18+
All Sexes
Miami, FL

This study aims to validate the accuracy and reliability of blood pressure (BP) estimates obtained over 24 hours using a PPG-based chest-patch device compared to the gold standard ambulatory blood pressure monitoring (ABPM) method using an upper arm cuff-based oscillometric BP device, in both hypertensive and normotensive individuals referred by their provider to undergo a 24-hours ABPM for clinical indication. The Awake/Asleep test, which is the primary test recommended for automated wearable cuffless BP devices that are cuff-calibrated (based on the 2023 European Society of Hypertension (ESH) recommendations for the validation of cuffless blood pressure measuring devices), will be conducted in this study. The secondary aim of the study is to assess the feasibility and convenience of the PPG-based device.

Waitlist Available
Has No Placebo

U Health (+1 Sites)

Ziad Zoghby, M.D., M.B.A.

Biobeat Technologies Ltd.

Image of UPMC Presybeterian in Pittsburgh, United States.

Telaglenastat for Pulmonary Hypertension

18 - 75
All Sexes
Pittsburgh, PA

The research study is being conducted to evaluate the effectiveness of a drug called Telaglenastat in adults diagnosed with Pulmonary Hypertension (PH). PH is a progressive condition that affects the arteries in the lungs, specifically the pulmonary arteries, which carry blood from the right side of the heart to the lungs. Telaglenastat is not currently approved by the Food and Drug Administration for the treatment of PH. However, the study investigators believe that Telaglenastat may help lower blood pressure in the lungs and improve both heart and lung function. It is important to note that the drug will not be available to participants once the study concludes.

Phase 1 & 2
Waitlist Available

UPMC Presybeterian

Michael Risbano, MD

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Dietary Interventions for Hypertension

18+
All Sexes
Birmingham, AL

Natriuretic peptides (NPs) are hormones produced by the heart and play an important role in maintaining cardiovascular health and have favorable metabolic benefits. Low NP levels are associated with an increased likelihood of the development of cardiometabolic diseases like diabetes and hypertension. NP levels are known to be highly heritable, with up to half of the differences in NP levels being explained by genetics. The investigators aim to describe the genetic architecture of NPs by examining the genetic variants associated with NPs, and generate and validate a polygenic score (PGS) for NPs. The investigators will use this NP PGS to examine the association of genetically determined NP levels with cardiometabolic and cardiovascular outcomes. The investigators will conduct a genotype-guided physiological clinical trial that aims to assess the genetic factors affecting NP levels and their impact on blood pressure and NP response to saline infusion, high-salt diet, and low-salt diet. These findings will help support personal medicine approaches to lower the increasing burden of hypertension in the United States.

Waitlist Available
Has No Placebo

University of Alabama at Birmingham

Pankaj Arora, MD, FAHA

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PF-07868489 for Pulmonary Hypertension

18+
All Sexes
San Francisco, CA

The purpose of this study is to learn about the long-term safety, tolerability and effects of the study medicine (PF-07868489) for the possible treatment of PAH. PAH is a condition in which there is high blood pressure in the arteries that carry blood from the heart to the lungs. This high pressure makes it harder for the heart to pump blood through those lungs, potentially damaging the right side of the heart. This is an open-label study. Which means that both the healthcare providers and the study participants are aware of the medicine being given. This study is also an extension study with study medicine (PF-07868489). An extension study allows patients from an earlier clinical study (also called as qualifying study) to continue participating to assess long-term benefits and safety of the medicine.

Phase 2
Recruiting

UCSF Health St. Mary's Hospital (+6 Sites)

Pfizer CT.gov Call Center

Pfizer

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