Adalat

Anal sphincter hypertonia, Proctalgia, Other and unspecified effects of high altitude + 12 more

Treatment

3 FDA approvals

20 Active Studies for Adalat

Treatment for

Anal sphincter hypertonia

What is Adalat

NifedipineThe Generic name of this drug

Treatment SummaryNifedipine (brand name BAY a 1040) is a type of medication used to treat high blood pressure. It belongs to a class of drugs known as calcium channel blockers and is the first of its kind to be developed. Nifedipine works by blocking calcium from entering the cells in the walls of arteries, which reduces tension and widens them. This helps to lower blood pressure and improve blood flow. There are newer, second and third generation versions of nifedipine with slower onset times and longer-lasting effects, such as amlodipine. Nifedipine was approved by

Procardiais the brand name

image of different drug pills on a surface

Adalat Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Procardia

Nifedipine

1981

355

Approved as Treatment by the FDA

Nifedipine, otherwise called Procardia, is approved by the FDA for 3 uses like Vasospastic Angina and Chronic Stable Angina Pectoris .

Vasospastic Angina

Helps manage Vasospastic Angina

Chronic Stable Angina Pectoris

Helps manage Chronic Stable Angina Pectoris

Failed conventional therapy

Helps manage Failed conventional therapy

Effectiveness

How Adalat Affects PatientsNifedipine is a medication that helps to lower blood pressure and increase the amount of oxygen that reaches the heart. It needs to be taken three times a day, typically in doses of 10 to 120mg daily. It is important for patients to be aware of the risks associated with taking this medication, such as excessively low blood pressure, chest pain and heart attack.

How Adalat works in the bodyNifedipine helps reduce blood pressure and ease chest pain by blocking the entry of calcium ions into cells. This stops the cells from becoming over-stimulated, allowing blood vessels to relax and provide more oxygen to the heart.

When to interrupt dosage

The suggested dose of Adalat is contingent upon the diagnosed condition, including Achalasia, Ureteral Calculus and Hypertensive disease. The amount of dosage varies, as per the method of delivery (e.g. Tablet, film coated, extended release or Capsule) specified in the table below.

Condition

Dosage

Administration

Hypertensive Emergency

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Chronic Stable Angina Pectoris

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Anal sphincter hypertonia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Proctalgia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Vasospastic Angina

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Fissure;Anal

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Failed conventional therapy

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Pulmonary Edemas

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Ureteral Calculus

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Premature Labour

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Hypertensive disease

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Other and unspecified effects of high altitude

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Raynaud's Phenomenon

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Achalasia

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Pulmonary Hypertension

30.0 mg, 60.0 mg, 90.0 mg, , 10.0 mg, 20.0 mg, 5.0 mg, 20.0 mg/mL

, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Capsule, liquid filled, Capsule, liquid filled - Oral, Tablet, extended release, Tablet, extended release - Oral, Capsule, Capsule - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Kit; Tablet, delayed release; Tablet, extended release, Kit; Tablet, delayed release; Tablet, extended release - Oral

Warnings

Adalat has one contraindication, thus its use should be avoided if any of the situations in the table below are present.Adalat Contraindications

Condition

Risk Level

Notes

Severe Hypersensitivity Reactions

Do Not Combine

Nifedipine may interact with Pulse Frequency

There are 20 known major drug interactions with Adalat.

Common Adalat Drug Interactions

Drug Name

Risk Level

Description

Amitriptyline

Major

The metabolism of Amitriptyline can be decreased when combined with Nifedipine.

Amoxapine

Major

The metabolism of Amoxapine can be decreased when combined with Nifedipine.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Nifedipine is combined with Artemether.

Adalat Toxicity & Overdose RiskThe lowest toxic dose of the drug in rats was found to be 1022mg/kg and in mice was 202mg/kg. An overdose on this drug may cause low blood pressure, problems with the heart rate, and rapid heartbeat. Treatment for an overdose should involve monitoring vital signs, raising the patient's extremities, and administering fluids, vasopressors, and calcium.

image of a doctor in a lab doing drug, clinical research

Adalat Novel Uses: Which Conditions Have a Clinical Trial Featuring Adalat?

101 active investigations are exploring the potential of Adalat to mitigate Achalasia, Hypertensive Emergency and Anal Fissures.

Condition

Clinical Trials

Trial Phases

Other and unspecified effects of high altitude

1 Actively Recruiting

Phase 2

Pulmonary Hypertension

21 Actively Recruiting

Phase 2, Phase 3, Not Applicable, Phase 1, Early Phase 1

Proctalgia

0 Actively Recruiting

Raynaud's Phenomenon

1 Actively Recruiting

Phase 4

Pulmonary Edemas

0 Actively Recruiting

Vasospastic Angina

1 Actively Recruiting

Phase 2, Phase 3

Anal sphincter hypertonia

0 Actively Recruiting

Ureteral Calculus

0 Actively Recruiting

Failed conventional therapy

0 Actively Recruiting

Hypertensive disease

20 Actively Recruiting

Not Applicable, Phase 1, Phase 2, Phase 3

Hypertensive Emergency

1 Actively Recruiting

Phase 4

Fissure;Anal

0 Actively Recruiting

Premature Labour

4 Actively Recruiting

Not Applicable, Phase 2

Achalasia

7 Actively Recruiting

Phase 2, Not Applicable, Phase 4

Chronic Stable Angina Pectoris

1 Actively Recruiting

Not Applicable

Adalat Reviews: What are patients saying about Adalat?

5Patient Review

11/13/2007

Adalat for Angina

3Patient Review

1/16/2008

Adalat for Angina

My blood pressure and chest pain are much more manageable now.

image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about adalat

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is nifedipine and Adalat the same thing?

"Nifedipine is available as an oral tablet in the brand-name drugs Adalat CC, Afeditab CR, and Procardia XL. These are all extended-release tablets, meaning the drug is slowly released into your bloodstream over time."

Answered by AI

When do you give Adalat?

"It is recommended that you take Adalat CC once a day on an empty stomach. Adalat CC is an extended release dosage form, which means you should swallow the tablet whole, without biting or dividing it. In general, you should start with 30 mg once a day, and increase the dosage over a 7-14 day period."

Answered by AI

Is Adalat for blood pressure?

"Nifedipine, sold under the brand name Adalat, is a calcium channel blocker used to lower high blood pressure and treat chest pain. Nifedipine slows the movement of calcium into the cells of the heart and blood vessels. This relaxes the blood vessels, lowers blood pressure, and makes it easier for the heart to pump."

Answered by AI

What is Adalat used for?

"This medication prevents certain types of chest pain by blocking calcium channels. This allows the individual to exercise more and have fewer angina attacks."

Answered by AI

Clinical Trials for Adalat

Image of Mount Blue Sky in Evergreen, United States.

Prochlorperazine for Altitude Sickness

This trial is testing a drug called prochlorperazine to see if it can prevent acute mountain sickness. Participants will either take the drug or a fake pill (placebo) and go on a hike

Mount Blue SkyElan Small, MD

Image of Arkansas Children's Nutrition Center in Little Rock, United States.

Exercise for High Blood Pressure in Teens

Little Rock, AR

This trial aims to see if isometric exercises like squats and planks are better at improving blood pressure in teens aged 13 to 17.5 years compared to aerobic exercises like running. Adoles

Waitlist Available

Arkansas Children's Nutrition CenterEva C Diaz

Image of Stanford Hospital in Palo Alto, United States.

Targeted Medical Therapy for Angina

This trial aims to see if a specific medical treatment can help improve symptoms and quality of life in patients with chest pain and clear arteries, compared to a fake treatment. Participants will receive either the real treatment

Waitlist Available

Stanford HospitalJennifer Tremmel, MD

Image of Tufts University in Boston, United States.

Food as Medicine for Cardiometabolic Health

This trial focuses on improving the health of residents in the Mississippi Delta, who have faced food insecurity and poverty due to historical factors. The project aims to provide a "Food is Medicine" intervention through distributing

Tufts UniversityChristina D Economos, PhD

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Supplemental Oxygen for Pulmonary Hypertension

This trial aims to see if giving extra oxygen during dialysis can help people with high blood pressure in the lungs and low oxygen levels during dialysis.

Waitlist Available

No Cost For Treatment

Davita Durham East (+10 Sites)Daniel Edmonston, MD, MHS

Image of Cedars-Sinai Medical Center in Los Angeles, United States.

Inhaled Nitric Oxide for ARDS-related Pulmonary Hypertension

Los Angeles, CA

"This trial is studying the use of inhaled nitric oxide for patients who develop pulmonary hypertension during Acute Respiratory Distress Syndrome. The goal is to see if giving nitric oxide early in the

Waitlist Available

Cedars-Sinai Medical CenterYuri Matusov, MDMallinckrodt

Image of Mayo Clinic in Rochester in Rochester, United States.

Losartan for Coarctation of the Aorta

This trial investigates if a drug called Losartan can help treat a condition called coarctation of aorta.

Mayo Clinic in RochesterAlexander Egbe, MBBS, MPH

Image of UT Southwestern Medical Center in Dallas, United States.

Polypill for Cardiomyopathy Prevention in Type 2 Diabetes

This trial will test if a polypill with 3 meds can help people with type 2 diabetes and a high risk of heart failure. It will measure if it improves med adherence and physical performance, compared to usual care.

UT Southwestern Medical CenterAmbarish Pandey, MD, MSCS

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Image of St. Louis Heart and Vascular in Saint Louis, United States.

Levosimendan for Pulmonary Hypertension with Heart Failure

Saint Louis, MO

This trial is going to compare the effectiveness of a medication called TNX-103 (levosimendan) with a placebo in people who have a condition called PH-HFpEF. They

St. Louis Heart and Vascular (+22 Sites)Tenax Therapeutics, Inc.

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Blood Pressure Medication for Early Pregnancy Hypertension

This trial is testing whether treating high blood pressure in early pregnancy with specific medications (nifedipine or labetalol) improves health outcomes for mothers and babies. The study focuses on pregnant women with elevated blood pressure. These medications work by relaxing blood vessels or slowing the heart rate to lower blood pressure. Nifedipine and labetalol are commonly used medications for high blood pressure in pregnancy, with studies showing their effectiveness in managing hypertensive disorders of pregnancy.

Marshall Obstetrics and Gynecology

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Tadalafil for COPD with Pulmonary Hypertension

This trial is testing whether tadalafil can help Veterans with COPD and high blood pressure in the lungs by reducing shortness of breath and improving overall health. The drug works by relaxing blood vessels to improve blood flow. The study will compare tadalafil to another group over several months to see if it makes a significant difference in symptoms and quality of life. Tadalafil received FDA approval in 2009 for the treatment of pulmonary arterial hypertension (PAH) and has shown to improve exercise capacity and quality of life in patients.

Waitlist Available

Rocky Mountain Regional VA Medical Center, Aurora, CO (+4 Sites)Sharon I Rounds, MD

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Exercise Training for Right Ventricular Dysfunction in COPD

This trial will assess how COPD affects heart function and explore new treatments to improve outcomes.

University of Colorado Anschutz Medical CampusLindsay Forbes, MD

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