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What is Requip Xl
RopiniroleThe Generic name of this drug
Treatment SummaryRopinirole, also known as ReQuip, is a medication used to treat Parkinson's disease and restless legs syndrome. It was approved by the FDA in 1997 for Parkinson's disease and in 2005 for restless legs syndrome. In 2008, extended-release capsules were approved, allowing patients to take the medication less often while still having the same effectiveness and side effects as the original version. Ropinirole is manufactured by GlaxoSmithKline Pharmaceuticals.
Requipis the brand name
Requip Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Requip
Ropinirole
1997
379
Approved as Treatment by the FDA
Ropinirole, otherwise called Requip, is approved by the FDA for 4 uses such as Primary and Restless Legs Syndrome .Primary
Restless Legs Syndrome
Parkinson's Disease
Helps manage Parkinson's Disease (PD)
Restless Legs Syndrome
Effectiveness
How Requip Xl Affects Patients**Effects on Parkinson's and Restless Leg Syndrome**
This drug helps improve symptoms of Parkinson's or restless leg syndrome by stimulating the dopamine receptors in the body, which control movement. **Effects on Blood Pressure**Ropinirole can cause blood pressure changes in some people, leading to dizziness or fainting. This is believed to be due to a decrease in the body's ability to regulate blood pressure when standing. Nausea is also a common symptom with these blood pressure changes. **Effects on Prolactin**Taking as little as 0.2 mg of
How Requip Xl works in the bodyRopinirole is a drug that helps treat Parkinson's and Restless Legs Syndrome by stimulating certain dopamine receptors in the brain. It has the highest affinity for D3 receptors, which are found in the limbic areas of the brain, and it also stimulates D2 receptors in the caudate-putamen system. It has no effect on other receptors such as alpha2 adrenoreceptors, 5HT-1 receptors, or GABA receptors. We don't know exactly how it works to treat these conditions, but we think it is related to its ability to stimulate dopamine receptors.
When to interrupt dosage
The endorsed dosage of Requip Xl is subject to the diagnosed affliction, comprising of Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease. The quantity of dosage is contingent upon the delivery method specified in the table below.Condition
Dosage
Administration
Primary
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson's Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Warnings
Requip Xl ContraindicationsCondition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ropinirole may interact with Pulse Frequency
Common Requip Xl Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Acebutolol.
Aliskiren
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Aliskiren.
Ambrisentan
Minor
Ropinirole may increase the hypotensive activities of Ambrisentan.
Amifostine
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amifostine.
Amiloride
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amiloride.
Requip Xl Toxicity & Overdose RiskOverdosing on ropinirole can cause agitation, chest pain, confusion, drowsiness, uncontrollable muscle movements, light-headedness when standing, nausea, and vomiting. Animal studies found an increase in tumors in male rats and uterine polyps in female mice at high doses. The drug was not found to be mutagenic or clastogenic. Ropinirole can disrupt implantation in pregnant rats, but no studies have been done in pregnant women. Pregnancy Category C means that it has the potential to cause harm to an unborn baby.
Requip Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Requip Xl?
51 active clinical trials are currently being conducted to assess the utility of Requip Xl in treating Restless Legs Syndrome, Parkinson Disease and related Restless Legs Syndrome symptoms.Condition
Clinical Trials
Trial Phases
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Not Applicable, Phase 2
Parkinson's Disease
46 Actively Recruiting
Phase 3, Not Applicable, Phase 1, Phase 2, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting
Primary
0 Actively Recruiting
Restless Legs Syndrome
0 Actively Recruiting
Requip Xl Reviews: What are patients saying about Requip Xl?
5Patient Review
1/21/2012 Requip XL has helped me a lot during the day, but by early evening the effects seem to wear off and my RLS becomes quite painful. Soaking in a hot tub is usually the only thing that provides relief.
5Patient Review
3/12/2015 Ropinirole Er has been a huge help to me, however I have experienced some unexpected nocturnal urination. Has anyone else experienced this? Could there be a connection?
5Patient Review
8/2/2013 Though this medication has helped with my restless leg syndrome, it's also killed my sex drive. Unfortunately, that's led to some difficulties in my marriage.
5Patient Review
10/22/2013 This treatment has greatly improved my quality of life.
5Patient Review
6/10/2018 I have severe restless legs syndrome.
4.7Patient Review
5/25/2012 I experienced numbness in my left stomach and blurred vision after taking this medication.
4.3Patient Review
9/28/2011 It can sometimes take a little while for this to work, but it's worth being consistent with the dosage.
3.7Patient Review
9/10/2012 Unfortunately, this drug had some pretty severe side effects for me. I was constantly awake and felt like I had to be doing something all the time. As a result, my quality of life suffered quite a bit. It took my doctor over a year to figure out what was wrong. So, in short, I would not recommend this drug to anyone.
3.3Patient Review
1/14/2012 I've been taking RequipXL for about 12 years now and it's really helped me maintain an active lifestyle. I don't think I could continue playing golf 18 holes a day without it. The side effects have been manageable, although I would like to increase my dosage even more.
3.3Patient Review
7/24/2013 I take requipxl alongside other medication to help me get by.
1.3Patient Review
8/18/2012 Withdrawal from this drug has been both gradual and horrifying. I experienced a range of symptoms including nausea, diarrhea, headaches, confusion, and abdominal pain. Please be very careful if you decide to stop taking this medication.
1Patient Review
1/21/2012 Requip XL time release was a complete game-changer for me. I had been struggling with nausea for years, and this medicine completely alleviated that issue. Additionally, my balance and tremor improved, and I was even able to pick up knitting again!
1Patient Review
8/1/2012 I had a lot of negative reactions to this medication, including confusion, dizziness, headaches, and muscle spasms. I stopped taking it for a while, but now I only take half the dosage every other night.
Patient Q&A Section about requip xl
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.How long does Requip XL last?
"The purpose of REQUIP XL is to provide a steady release of medication over the course of a day."
Answered by AI
What are the side effects from Requip?
"These are some of the side effects that may occur. If they persist or get worse, be sure to tell your doctor."
Answered by AI
What is Requip XL used for?
"Requip XL helps to restore the balance of dopamine in the brain in order to treat the symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control."
Answered by AI
How long does the extended-release ropinirole last?
"Ropinirole extended-release tablets are designed to release medication over a 24-hour period. If rapid gastrointestinal transit occurs, there is a risk of incomplete release of medication and medication residue being passed in the stool."
Answered by AI