Requip Xl

Parkinson Disease, Parkinson's Disease, Primary + 2 more
Treatment
7 FDA approvals
20 Active Studies for Requip Xl

What is Requip Xl

RopiniroleThe Generic name of this drug
Treatment SummaryRopinirole, also known as ReQuip, is a medication used to treat Parkinson's disease and restless legs syndrome. It was approved by the FDA in 1997 for Parkinson's disease and in 2005 for restless legs syndrome. In 2008, extended-release capsules were approved, allowing patients to take the medication less often while still having the same effectiveness and side effects as the original version. Ropinirole is manufactured by GlaxoSmithKline Pharmaceuticals.
Requipis the brand name
image of different drug pills on a surface
Requip Xl Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Requip
Ropinirole
1997
379

Approved as Treatment by the FDA

Ropinirole, otherwise called Requip, is approved by the FDA for 7 uses such as Parkinson's Disease (PD) and Severe restless legs syndrome (RLS) .
Parkinson's Disease (PD)
Helps manage Parkinson's Disease (PD)
Severe restless legs syndrome (RLS)
Moderate restless legs syndrome (RLS)
Primary
Restless Legs Syndrome
Restless Legs Syndrome
Parkinson's Disease
Helps manage Parkinson's Disease (PD)

Effectiveness

How Requip Xl Affects Patients**Effects on Parkinson's and Restless Leg Syndrome** This drug helps improve symptoms of Parkinson's or restless leg syndrome by stimulating the dopamine receptors in the body, which control movement. **Effects on Blood Pressure**Ropinirole can cause blood pressure changes in some people, leading to dizziness or fainting. This is believed to be due to a decrease in the body's ability to regulate blood pressure when standing. Nausea is also a common symptom with these blood pressure changes. **Effects on Prolactin**Taking as little as 0.2 mg of
How Requip Xl works in the bodyRopinirole is a drug that helps treat Parkinson's and Restless Legs Syndrome by stimulating certain dopamine receptors in the brain. It has the highest affinity for D3 receptors, which are found in the limbic areas of the brain, and it also stimulates D2 receptors in the caudate-putamen system. It has no effect on other receptors such as alpha2 adrenoreceptors, 5HT-1 receptors, or GABA receptors. We don't know exactly how it works to treat these conditions, but we think it is related to its ability to stimulate dopamine receptors.

When to interrupt dosage

The endorsed dosage of Requip Xl is subject to the diagnosed affliction, comprising of Restless Legs Syndrome, Restless Legs Syndrome and Parkinson's Disease. The quantity of dosage is contingent upon the delivery method specified in the table below.
Condition
Dosage
Administration
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Restless Legs Syndrome
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Parkinson's Disease
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral
Primary
, 12.0 mg, 6.0 mg, 2.0 mg, 4.0 mg, 8.0 mg, 0.25 mg, 0.5 mg, 1.0 mg, 3.0 mg, 5.0 mg
, Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, coated, Tablet, coated - Oral

Warnings

Requip Xl Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Ropinirole may interact with Pulse Frequency
There are 20 known major drug interactions with Requip Xl.
Common Requip Xl Drug Interactions
Drug Name
Risk Level
Description
Acebutolol
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Acebutolol.
Aliskiren
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Aliskiren.
Ambrisentan
Minor
Ropinirole may increase the hypotensive activities of Ambrisentan.
Amifostine
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amifostine.
Amiloride
Minor
The risk or severity of adverse effects can be increased when Ropinirole is combined with Amiloride.
Requip Xl Toxicity & Overdose RiskOverdosing on ropinirole can cause agitation, chest pain, confusion, drowsiness, uncontrollable muscle movements, light-headedness when standing, nausea, and vomiting. Animal studies found an increase in tumors in male rats and uterine polyps in female mice at high doses. The drug was not found to be mutagenic or clastogenic. Ropinirole can disrupt implantation in pregnant rats, but no studies have been done in pregnant women. Pregnancy Category C means that it has the potential to cause harm to an unborn baby.

Requip Xl Novel Uses: Which Conditions Have a Clinical Trial Featuring Requip Xl?

51 active clinical trials are currently being conducted to assess the utility of Requip Xl in treating Restless Legs Syndrome, Parkinson Disease and related Restless Legs Syndrome symptoms.
Condition
Clinical Trials
Trial Phases
Parkinson Disease
7 Actively Recruiting
Early Phase 1, Phase 2, Not Applicable
Restless Legs Syndrome
0 Actively Recruiting
Primary
0 Actively Recruiting
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Restless Legs Syndrome
0 Actively Recruiting

Requip Xl Reviews: What are patients saying about Requip Xl?

5Patient Review
1/21/2012
Requip Xl for Parkinson's Disease
Requip XL has helped me a lot during the day, but by early evening the effects seem to wear off and my RLS becomes quite painful. Soaking in a hot tub is usually the only thing that provides relief.
5Patient Review
3/12/2015
Requip Xl for Extreme Discomfort in Calves when Sitting or Lying Down
Ropinirole Er has been a huge help to me, however I have experienced some unexpected nocturnal urination. Has anyone else experienced this? Could there be a connection?
5Patient Review
8/2/2013
Requip Xl for Extreme Discomfort in Calves when Sitting or Lying Down
Though this medication has helped with my restless leg syndrome, it's also killed my sex drive. Unfortunately, that's led to some difficulties in my marriage.
5Patient Review
10/22/2013
Requip Xl for Parkinson's Disease
This treatment has greatly improved my quality of life.
5Patient Review
6/10/2018
Requip Xl for Extreme Discomfort in Calves when Sitting or Lying Down
I have severe restless legs syndrome.
View All Reviews

Patient Q&A Section about requip xl

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How long does Requip XL last?

"The purpose of REQUIP XL is to provide a steady release of medication over the course of a day."

Answered by AI

What are the side effects from Requip?

"These are some of the side effects that may occur. If they persist or get worse, be sure to tell your doctor."

Answered by AI

What is Requip XL used for?

"Requip XL helps to restore the balance of dopamine in the brain in order to treat the symptoms of Parkinson's disease, such as stiffness, tremors, muscle spasms, and poor muscle control."

Answered by AI

How long does the extended-release ropinirole last?

"Ropinirole extended-release tablets are designed to release medication over a 24-hour period. If rapid gastrointestinal transit occurs, there is a risk of incomplete release of medication and medication residue being passed in the stool."

Answered by AI

Clinical Trials for Requip Xl

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Have you considered Requip Xl clinical trials? We made a collection of clinical trials featuring Requip Xl, we think they might fit your search criteria.
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