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What is Rivastigmine
RivastigmineThe Generic name of this drug
Treatment SummaryRivastigmine is a medication used to treat mild to moderate Alzheimer's dementia. It works by increasing the amount of a chemical messenger in the brain which helps to improve memory and thinking skills. Rivastigmine is a type of drug known as a cholinesterase inhibitor, which works by blocking the breakdown of two important chemicals in the brain.
Rivastigmine Tartrateis the brand name
Rivastigmine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Rivastigmine Tartrate
Rivastigmine
2000
128
Approved as Treatment by the FDA
Rivastigmine, also known as Rivastigmine Tartrate, is approved by the FDA for 4 uses including Parkinson Disease and Alzheimer's Disease .Parkinson Disease
Helps manage mild Dementia due to Parkinson's disease
Alzheimer's Disease
Helps manage moderate Alzheimer's Type Dementia
Parkinson Disease
Helps manage moderate Dementia due to Parkinson's disease
mild Dementia of the Alzheimer's Type
Helps manage mild Dementia of the Alzheimer's Type
Effectiveness
How Rivastigmine Affects PatientsRivastigmine works by increasing the levels of a brain chemical called acetylcholine. Acetylcholine plays an important role in memory and thinking, and is known to be in low levels in people with Alzheimer's disease. Rivastigmine is thought to do this by blocking the enzyme (cholinesterase) that breaks down acetylcholine. However, as the disease progresses and fewer neurons are working, the effectiveness of rivastigmine may lessen.
How Rivastigmine works in the bodyRivastigmine works by blocking the enzymes that break down acetylcholine, a chemical in the brain that helps send messages between nerve cells. This means that the amount of acetylcholine in the brain increases, which can help improve thinking and memory. Rivastigmine is more effective in the brain than other parts of the body, so it can help with cognitive issues without causing too many side effects.
When to interrupt dosage
The proposed dosage of Rivastigmine is contingent upon the diagnosed state, such as Parkinson Disease, Parkinson Disease and Alzheimer's Disease. The dosage amount vacillates as per the technique of administration (e.g. Patch, extended release - Transdermal or Capsule - Oral) delineated in the table below.Condition
Dosage
Administration
Parkinson Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
mild Dementia of the Alzheimer's Type
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Parkinson Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Dementia
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Alzheimer's Disease
1.5 mg, , 3.0 mg, 4.5 mg, 6.0 mg, 0.46 mg/hour, 1.33 mg/hour, 0.95 mg/hour, 0.46 mg/[USP'U], 4.6 mg, 9.5 mg, 13.3 mg, 0.95 mg/[USP'U], 2.0 mg/mL, 9.0 mg/cm2, 1.8 mg/cm2
, Oral, Capsule, Capsule - Oral, Transdermal, Patch, extended release, Patch, extended release - Transdermal, Solution, Solution - Oral, Patch - Transdermal, Patch, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral
Warnings
Rivastigmine ContraindicationsCondition
Risk Level
Notes
Anniversary Reaction
Do Not Combine
Common Rivastigmine Drug Interactions
Drug Name
Risk Level
Description
Metoclopramide
Major
The risk or severity of adverse effects can be increased when Rivastigmine is combined with Metoclopramide.
Acetylcholine
Minor
The risk or severity of adverse effects can be increased when Rivastigmine is combined with Acetylcholine.
Agmatine
Minor
The therapeutic efficacy of Agmatine can be decreased when used in combination with Rivastigmine.
Alcuronium
Minor
The therapeutic efficacy of Alcuronium can be decreased when used in combination with Rivastigmine.
Amantadine
Minor
The therapeutic efficacy of Amantadine can be decreased when used in combination with Rivastigmine.
Rivastigmine Novel Uses: Which Conditions Have a Clinical Trial Featuring Rivastigmine?
17 active clinical trials are currently investigating the potential of Rivastigmine to ameliorate Dementia, Alzheimer's Disease and mild forms of Alzheimer's Type Dementia.Condition
Clinical Trials
Trial Phases
Parkinson Disease
0 Actively Recruiting
Dementia
18 Actively Recruiting
Phase 4, Not Applicable, Phase 1, Phase 2, Early Phase 1
Alzheimer's Disease
2 Actively Recruiting
Phase 3, Phase 2
Parkinson Disease
0 Actively Recruiting
mild Dementia of the Alzheimer's Type
0 Actively Recruiting
Rivastigmine Reviews: What are patients saying about Rivastigmine?
5Patient Review
10/14/2013 My mother took this medicine for only 3 days and had very bad diahrea, dehydrated, weakness, tired. She ended up in the hospital for 2 days!
5Patient Review
6/14/2017 I experienced some really bizarre dreams while using this treatment, and unfortunately it didn't actually help with my problem. It felt like a total ripoff.
4.7Patient Review
8/9/20083.7Patient Review
5/19/2015 I may not have gotten my lost memories back, but the rate of memory loss has decreased since I started this treatment. Additionally, it seems to take less time for me to recall memories now.
2.3Patient Review
5/22/2013 I accidentally gave my dad 12mg instead of 6mg a day. I didn't realize it until after a month later when I changed his dosage back to 6mg. Now he's complaining of headaches, sleepiness, and not being able to walk very well. His doctor won't return my phone calls until after the weekend. Is this normal response to the change in medication?
1.7Patient Review
9/30/2015 I've been taking this for a year now, and it's helped my memory some. I tried to quit taking it a few months ago but noticed my memory getting worse, so I started back up again.
1.3Patient Review
9/13/20101Patient Review
7/3/2018 Unfortunately, this medication has never agreed with me. Every time I have taken it, I have experienced intense nausea and vomiting, dizziness, an accelerated heartbeat, and paranoia.
Patient Q&A Section about rivastigmine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Does rivastigmine slow down dementia?
"Although transdermal rivastigmine may improve cognitive function or slow cognitive decline, it does not cure Alzheimer's disease or dementia in people with Parkinson's disease."
Answered by AI
What class of drug is rivastigmine?
"Rivastigmine is a type of medication that is designed to help improve mental function by increasing the levels of a natural substance in the brain."
Answered by AI
What does rivastigmine do to the brain?
"Rivastigmine is an acetylcholinesterase inhibitor that increases levels of the brain chemical acetylcholine, allowing for better communication between nerve cells. This can improve the symptoms of dementia. Rivastigmine can be taken as capsules or liquid orally, or applied as a patch to the skin."
Answered by AI
Does rivastigmine make you sleepy?
"This medicine can cause some people to become dizzy, drowsy, or less alert than they are normally. If this happens to you, do not drive, use machines, or do anything else that could be dangerous until you know how this medicine affects you."
Answered by AI