Artane

Extrapyramidal disorder, Extrapyramidal symptoms caused by dibenzoxazepines, Extrapyramidal symptoms caused by thioxanthenes + 5 more
Treatment
8 FDA approvals
9 Active Studies for Artane

What is Artane

TrihexyphenidylThe Generic name of this drug
Treatment SummaryTrihexyphenidyl is a medication used to treat Parkinson's disease and other movement disorders caused by certain medications. It was first approved by the FDA in 1949, but it is no longer used as a first-line treatment due to its potential side effects. It has been largely replaced by drugs like Levodopa.
Trihexyphenidyl Hydrochlorideis the brand name
image of different drug pills on a surface
Artane Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Trihexyphenidyl Hydrochloride
Trihexyphenidyl
1987
71

Approved as Treatment by the FDA

Trihexyphenidyl, also known as Trihexyphenidyl Hydrochloride, is approved by the FDA for 8 uses which include Parkinson Disease and Extrapyramidal disorder .
Parkinson Disease
Extrapyramidal disorder
Helps manage Extrapyramidal disorder
Parkinsonism post encephalitic
Extrapyramidal symptoms caused by dibenzoxazepines
Helps manage Extrapyramidal symptoms caused by dibenzoxazepines
Arteriosclerosis
Butyrophenones
Helps manage Extrapyramidal symptoms caused by butyrophenones
phenothiazine
Helps manage Extrapyramidal symptoms caused by phenothiazines
Extrapyramidal symptoms caused by thioxanthenes
Helps manage Extrapyramidal symptoms caused by thioxanthenes

Effectiveness

How Artane Affects PatientsTrihexyphenidyl is a medicine used to treat Parkinson's disease and other side effects from other drugs. It does not need to be taken every day, and is generally safe to use at high doses. However, people using this drug should have their eyes checked regularly and be warned of the potential risk of lack of sweat and overheating.
How Artane works in the bodyTrihexyphenidyl is a drug that helps treat symptoms of Parkinson’s disease and other movement disorders. It works by blocking a certain type of chemical messenger, called acetylcholine, in the brain and muscles. It is thought to also help increase dopamine levels in the brain, which is beneficial for movement control. The exact way it works is not yet known.

When to interrupt dosage

The suggested measure of Artane is contingent upon the diagnosed state, including phenothiazine, Extrapyramidal reactions caused by dibenzoxazepines and Butyrophenones. The amount of dosage fluctuates, in relation to the administration technique (e.g. Tablet or Tablet - Oral) shown in the following table.
Condition
Dosage
Administration
Parkinsonism post encephalitic
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Parkinson Disease
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by dibenzoxazepines
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
phenothiazine
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal symptoms caused by thioxanthenes
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Butyrophenones
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Extrapyramidal disorder
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral
Arteriosclerosis
, 2.0 mg/mL, 5.0 mg, 2.0 mg, 0.4 mg/mL
, Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Elixir, Elixir - Oral

Warnings

Artane Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Trihexyphenidyl may interact with Pulse Frequency
There are 20 known major drug interactions with Artane.
Common Artane Drug Interactions
Drug Name
Risk Level
Description
Aclidinium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Aclidinium.
Cimetropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Cimetropium.
Eluxadoline
Major
The risk or severity of constipation can be increased when Trihexyphenidyl is combined with Eluxadoline.
Glycopyrronium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Glycopyrronium.
Ipratropium
Major
The risk or severity of adverse effects can be increased when Trihexyphenidyl is combined with Ipratropium.
Artane Toxicity & Overdose RiskOverdosing on trihexyphenidyl can cause dry mouth, no sweating, dilated pupils, nausea, vomiting, rapid heartbeat, high fever, decreased digestion, difficulty urinating, rash, confusion, restlessness, poor coordination, paranoia, psychosis, delirium, and hallucinations. If left untreated, it can lead to respiratory failure, circulatory failure, and death. Treatment includes providing supportive care and airway maintenance, as well as potentially using a drug called physostigmine.
image of a doctor in a lab doing drug, clinical research

Artane Novel Uses: Which Conditions Have a Clinical Trial Featuring Artane?

Currently, 8 active clinical trials are being conducted to explore the potential of Artane to reduce Extrapyramidal symptoms caused by thioxanthenes, Post-Encephalitic Parkinsonism and Extrapyramidal symptomatology caused by dibenzoxazepines.
Condition
Clinical Trials
Trial Phases
phenothiazine
0 Actively Recruiting
Parkinson Disease
7 Actively Recruiting
Phase 3, Early Phase 1, Not Applicable, Phase 2
Parkinsonism post encephalitic
0 Actively Recruiting
Extrapyramidal symptoms caused by dibenzoxazepines
0 Actively Recruiting
Butyrophenones
0 Actively Recruiting
Extrapyramidal disorder
0 Actively Recruiting
Extrapyramidal symptoms caused by thioxanthenes
0 Actively Recruiting
Arteriosclerosis
2 Actively Recruiting
Phase 4, Not Applicable

Artane Reviews: What are patients saying about Artane?

5Patient Review
6/21/2014
Artane for Extrapyramidal Reaction
I feel really good when I take this medication. It's a great high and I get really horny, too. The orgasms are also way better.
5Patient Review
10/25/2017
Artane for Parkinson's Disease
This treatment was good and it helped me.
4.3Patient Review
2/16/2011
Artane for Parkinson Symptoms
I developed tardive dyskenesia from taking abilify, and was prescribed 10mg of Artane. This dosage was far too high for me, and caused extreme short-term memory loss for a few hours after taking it. After several doses, I started to feel nauseous, but drinking orange juice with pulp would help alleviate this. I now only take a quarter of a 5mg pill every now and then, which has kept my symptoms at bay. The Danbury brand is also much better than Qualitest in terms of not upsetting my stomach.
4.3Patient Review
12/21/2013
Artane for Extrapyramidal Reaction
I have oral mandibular dystonia, which this medication has helped me somewhat with.
4Patient Review
10/25/2014
Artane for Extrapyramidal Reaction
It increases my appetite and sex drive, as well as making me have to use the restroom more frequently.
3.7Patient Review
9/21/2010
Artane for Extrapyramidal Reaction
3.3Patient Review
7/2/2010
Artane for Parkinson's Disease
2.3Patient Review
4/24/2022
Artane for Extrapyramidal Reaction
This medication did its job in that I only had one faint myoclonic jerk while on it. However, I found it to be very cognitively impairing and memory- affecting. All in all, I would not recommend this medication because of these serious side effects.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about artane

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Does Artane cause anxiety?

"You may experience serious side effects from taking Artane, including fast or irregular heartbeats, anxiety, hallucinations, confusion, agitation, hyperactivity, or loss of consciousness. Seizures and eye pain are also possible. If you experience any of these symptoms, seek medical attention immediately."

Answered by AI

What is the drug Artane used for?

"Artane is an antispasmodic drug that is used to treat symptoms of Parkinson's disease, such as stiffness, tremors, spasms, and poor muscle control. Artane can also be used to prevent these symptoms when they are caused by certain drugs."

Answered by AI

Why is Artane used in schizophrenia?

"Anticholinergic drugs are used in psychiatric practice to counteract the side effect of EPS secondary to antipsychotic drugs. Trihexyphenidyl (Benzhexol), commonly known as 'Artane', is the most widely used anticholinergic drug in Zambia."

Answered by AI

How does Artane make you feel?

"tiredness, lightheadedness, constipation, flushing, nausea, nervousness, blurred vision, or dry mouth may occur. These effects generally improve as your body becomes accustomed to the medication. If any of these effects persist or worsen, contact your doctor or pharmacist."

Answered by AI

Clinical Trials for Artane

Have you considered Artane clinical trials? We made a collection of clinical trials featuring Artane, we think they might fit your search criteria.