Pimozide

Tics, Delusional Parasitosis, Tourette's Disorder (TD)
Treatment
2 FDA approvals
7 Active Studies for Pimozide

What is Pimozide

PimozideThe Generic name of this drug
Treatment SummaryPimozide is a drug used to treat psychosis and reduce vocal and motor tics in people with Tourette Syndrome. Its exact mechanism of action is unclear, but it is believed to work by blocking dopamine receptors in the brain.
Orapis the brand name
image of different drug pills on a surface
Pimozide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Orap
Pimozide
1990
6

Approved as Treatment by the FDA

Pimozide, otherwise called Orap, is approved by the FDA for 2 uses including Tics and Tourette's Disorder (TD) .
Tics
Helps manage Tics
Tourette's Disorder (TD)
Helps manage Tourette's Disorder (TD)

Effectiveness

How Pimozide Affects PatientsPimozide is an oral medication used to treat mental illnesses. It blocks the dopamine receptors in the brain and causes changes to dopamine metabolism and function, which can provide therapeutic benefits as well as unwanted side effects. Unlike other antipsychotics, it does not cause as much sedation or low blood pressure, so it is a good alternative to haloperidol.
How Pimozide works in the bodyPimozide works to reduce tics in Tourette's Syndrome by blocking dopamine receptors in the brain.

When to interrupt dosage

The measure of Pimozide is contingent upon the perceived affliction, including Tourette's Disorder (TD), Tics and Delusional Parasitosis. The amount of dosage is contingent upon the administration method delineated in the table beneath.
Condition
Dosage
Administration
Tics
1.0 mg, , 2.0 mg, 4.0 mg, 10.0 mg
, Oral, Tablet, Tablet - Oral
Delusional Parasitosis
1.0 mg, , 2.0 mg, 4.0 mg, 10.0 mg
, Oral, Tablet, Tablet - Oral
Tourette's Disorder (TD)
1.0 mg, , 2.0 mg, 4.0 mg, 10.0 mg
, Oral, Tablet, Tablet - Oral

Warnings

Pimozide Contraindications
Condition
Risk Level
Notes
simple tics
Do Not Combine
Pulse Frequency
Do Not Combine
Cardiac Arrhythmia
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypomagnesemia
Do Not Combine
Pulse Frequency
Do Not Combine
Mental Depression
Do Not Combine
Pulse Frequency
Do Not Combine
Comatose
Do Not Combine
Pulse Frequency
Do Not Combine
Long QT Syndrome
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Hypokalemia
Do Not Combine
Tic, Vocal
Do Not Combine
There are 20 known major drug interactions with Pimozide.
Common Pimozide Drug Interactions
Drug Name
Risk Level
Description
2,5-Dimethoxy-4-ethylamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylamphetamine can be decreased when used in combination with Pimozide.
2,5-Dimethoxy-4-ethylthioamphetamine
Major
The therapeutic efficacy of 2,5-Dimethoxy-4-ethylthioamphetamine can be decreased when used in combination with Pimozide.
4-Bromo-2,5-dimethoxyamphetamine
Major
The therapeutic efficacy of 4-Bromo-2,5-dimethoxyamphetamine can be decreased when used in combination with Pimozide.
Aminophylline
Major
The metabolism of Aminophylline can be decreased when combined with Pimozide.
Amisulpride
Major
Pimozide may increase the antipsychotic activities of Amisulpride.
Pimozide Toxicity & Overdose RiskThe lowest dose of the drug at which half of the test rats or mice die is 1100 mg/kg for rats and 228 mg/kg for mice.
image of a doctor in a lab doing drug, clinical research

Pimozide Novel Uses: Which Conditions Have a Clinical Trial Featuring Pimozide?

11 active studies are currently being conducted to examine the potential of Pimozide in providing relief for symptoms of Tics, Tourette's Disorder (TD) and Delusional Parasitosis.
Condition
Clinical Trials
Trial Phases
Tourette's Disorder (TD)
2 Actively Recruiting
Not Applicable, Phase 3
Tics
5 Actively Recruiting
Not Applicable, Phase 2
Delusional Parasitosis
0 Actively Recruiting

Pimozide Reviews: What are patients saying about Pimozide?

5Patient Review
3/13/2010
Pimozide for Mental Disorder with Loss of Normal Personality & Reality
The generic brands for this drug aren't working, and it's Not available in India.
3.7Patient Review
5/17/2018
Pimozide for Tourette's
This drug was effective at decreasing tics, but after having my son's hormones checked, we found that they were all messed up. I'm highly suspicious that this drug is the reason, and so we're going to try to come off of it and see if his hormones go back to normal.
3.3Patient Review
8/18/2014
Pimozide for Tourette's
Of all the medication my grandson has taken, this one has been the most effective.
3Patient Review
3/15/2010
Pimozide for Osteoporosis
This treatment really helped me. I'm grateful for modern medicine.
1.7Patient Review
3/13/2018
Pimozide for Tourette's
This medication made me tired and apathetic. It would work sometimes, but I always felt worse when I was on it, so I stopped taking it. Definitely not worth it for tourettes.
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Patient Q&A Section about pimozide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is pimozide used for?

"Pimozide is a drug that helps to control the vocal outbursts and uncontrolled, repeated movements of the body (tics) that may interfere with the patient's normal life. It will not completely cure the tics, but will help to reduce their number and severity."

Answered by AI

Is pimozide first generation antipsychotic?

"Pimozide is a first generation antipsychotic drug which is used to treat positive symptoms including hallucinations and delusions. It is older than the second generation antipsychotic drugs."

Answered by AI

Is pimozide used for schizophrenia?

"Pimozide was formulated in the late 1960s and is still used to treat people with schizophrenia or similar mental illnesses like delusional disorder. It's usually well-tolerated, but can cause movement disorders."

Answered by AI

Clinical Trials for Pimozide

Have you considered Pimozide clinical trials? We made a collection of clinical trials featuring Pimozide, we think they might fit your search criteria.