IMC-002 for Cancer
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new treatment called IMC-002 to determine its safety and effectiveness for people with certain advanced cancers. It targets individuals with solid tumors that have spread or cannot be surgically removed, as well as those with lymphomas unresponsive to previous treatments. Participants must have a confirmed diagnosis of these conditions and no available treatments that improve survival. The trial aims to discover how the body processes the drug and its effects on the cancer. As a Phase 1 trial, participants will be among the first to receive this treatment, aiding researchers in understanding its function in people.
Will I have to stop taking my current medications?
The trial protocol does not specify if you must stop taking your current medications, but you cannot take certain drugs within 28 days before starting the study treatment.
Is there any evidence suggesting that IMC-002 is likely to be safe for humans?
Research has shown that IMC-002 was safe in earlier studies. Patients who received IMC-002 through an IV every two weeks, at doses up to 30 mg/kg, tolerated it well, with no major safety issues at these doses. Additionally, tests on animals at even higher doses—up to 100 mg/kg—showed good tolerance without any blood-related problems. This suggests that IMC-002 is generally safe at the tested doses. As this trial marks the first time IMC-002 is being tested in humans, researchers are closely monitoring safety.12345
Why do researchers think this study treatment might be promising?
IMC-002 is unique because it targets tumors and lymphomas in a different way than most current treatments. While many existing therapies focus on destroying cancer cells directly, IMC-002 is designed to modulate the immune system, potentially enhancing its ability to recognize and attack cancer cells. Researchers are excited about this treatment because it could offer a more targeted approach, potentially leading to better outcomes with fewer side effects compared to traditional chemotherapy and radiation. This innovative mechanism makes IMC-002 a promising option for patients with metastatic or locally advanced solid tumors and relapsed or refractory lymphomas.
What evidence suggests that IMC-002 might be an effective treatment for solid tumors and lymphomas?
Research has shown that IMC-002 holds promise for treating advanced solid tumors and certain lymphomas. Early data from ongoing studies suggest that IMC-002, the investigational treatment in this trial, could be effective. In one study, patients with liver cancer (HCC) who had limited treatment options responded well when IMC-002 was combined with lenvatinib. Researchers observed no severe side effects at various doses, indicating that the treatment is generally well-tolerated. While more research is needed, early results offer hope for those with hard-to-treat cancers.26789
Who Is on the Research Team?
HEUNG TAE KIM
Principal Investigator
ImmuneOncia Therapeutics Inc.
Are You a Good Fit for This Trial?
Inclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Dose Escalation
Participants receive escalating doses of IMC-002 to assess safety and tolerability
Expansion Cohorts
Participants receive IMC-002 at the recommended Phase 2 dose to further evaluate safety
Follow-up
Participants are monitored for safety and effectiveness after treatment
What Are the Treatments Tested in This Trial?
Interventions
- IMC-002
Find a Clinic Near You
Who Is Running the Clinical Trial?
ImmuneOncia Therapeutics Inc.
Lead Sponsor