Teriflunomide

Multiple Sclerosis
Treatment
1 FDA approval
20 Active Studies for Teriflunomide

What is Teriflunomide

TeriflunomideThe Generic name of this drug
Treatment SummaryTeriflunomide, also known as Aubagio®, is a medication used to treat multiple sclerosis. It works by reducing the activity of the immune system, which helps reduce inflammation and relapses. However, teriflunomide can have serious side effects, such as liver damage and birth defects, so patients must be carefully monitored while taking this medication.
Aubagiois the brand name
image of different drug pills on a surface
Teriflunomide Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Aubagio
Teriflunomide
2013
44

Approved as Treatment by the FDA

Teriflunomide, also known as Aubagio, is approved by the FDA for 1 uses which include Multiple Sclerosis .
Multiple Sclerosis
Helps manage Multiple Sclerosis

Effectiveness

How Teriflunomide Affects PatientsTeriflunomide is a drug that helps to reduce inflammation and prevent cell growth in the central nervous system. It does this by reducing the amount of active white blood cells in the CNS.
How Teriflunomide works in the bodyTeriflunomide works by preventing cells from producing pyrimidine, a compound essential for proper functioning. This stops cells from producing energy and boosts the immune system's ability to fight off MS.

When to interrupt dosage

The suggested measure of Teriflunomide is contingent upon the diagnosed condition. The amount of dosage is contingent upon the delivery approach (e.g. Tablet, film coated or Tablet - Oral) featured in the table beneath.
Condition
Dosage
Administration
Multiple Sclerosis
, 14.0 mg, 7.0 mg
, Oral, Tablet, Tablet - Oral, Tablet, film coated, Tablet, film coated - Oral

Warnings

Teriflunomide Contraindications
Condition
Risk Level
Notes
Severe Hepatic Impairment
Do Not Combine
females of reproductive potential
Do Not Combine
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Teriflunomide.
Common Teriflunomide Drug Interactions
Drug Name
Risk Level
Description
9-(N-methyl-L-isoleucine)-cyclosporin A
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with 9-(N-methyl-L-isoleucine)-cyclosporin A.
Acteoside
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with Acteoside.
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Teriflunomide.
Antilymphocyte immunoglobulin (horse)
Major
The risk or severity of adverse effects can be increased when Teriflunomide is combined with Antilymphocyte immunoglobulin (horse).
Bacillus calmette-guerin substrain russian BCG-I live antigen
Major
The therapeutic efficacy of Bacillus calmette-guerin substrain russian BCG-I live antigen can be decreased when used in combination with Teriflunomide.
Teriflunomide Toxicity & Overdose RiskWomen who are pregnant or of childbearing age should not take teriflunomide due to the potential risk of birth defects. Additionally, those with severe liver damage should avoid this drug because it can cause liver toxicity, liver failure, and death.
image of a doctor in a lab doing drug, clinical research

Teriflunomide Novel Uses: Which Conditions Have a Clinical Trial Featuring Teriflunomide?

193 active clinical trials are underway to investigate the potential of Teriflunomide to mitigate Multiple Sclerosis symptoms.
Condition
Clinical Trials
Trial Phases
Multiple Sclerosis
194 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Phase 1, Phase 4, Early Phase 1

Teriflunomide Reviews: What are patients saying about Teriflunomide?

3.7Patient Review
8/19/2014
Teriflunomide for Multiple Sclerosis Symptoms Return then Become Less Severe
The medicine appears to be effective, but the side-effects are becoming increasingly unpleasant. In particular, I have experienced worsening diarrhea over the seven months that I've been taking it. Additionally, I have suffered from hair loss and weight loss (though the latter is not necessarily a bad thing). Some of my symptoms have improved since starting this medication regimen.
3.7Patient Review
3/2/2014
Teriflunomide for Multiple Sclerosis Symptoms Return then Become Less Severe
The longer I took this medication, the more side effects developed. These included hair loss, dizziness, feeling lightheaded, visual changes, terrible taste and joint stiffness.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about teriflunomide

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is teriflunomide FDA approved?

"The U.S. Food and Drug Administration has approved teriflunomide, a once-daily pill, to treat relapsing forms of MS. This is the second oral disease-modifying therapy approved for the treatment of multiple sclerosis."

Answered by AI

What does Aubagio do to your body?

"Tell your doctor right away if you have any new or worsening skin problems, such as a rash, blisters, peeling skin, redness, or itching.

Aubagio may cause severe skin reactions, including Stevens-Johnson syndrome, which can be life-threatening. If you experience any new or worsening skin problems, such as a rash, blisters, peeling skin, redness, or itching, you should contact your doctor immediately."

Answered by AI

Is teriflunomide an immunosuppressant?

"The results of the study showed that Teriflunomide and Cladribine are both effective in treating MS patients. Teriflunomide, in particular, was shown to reduce the annualized relapse rate (ARR) by more than 30% and disability progression by 30% compared to placebo."

Answered by AI

What is teriflunomide used for?

"This medicine is used to treat the relapsing forms of multiple sclerosis (MS), including clinically isolated syndrome, relapsing-remitting disease, and active secondary progressive disease. This medicine will not cure MS, but it may slow some disabling effects and decrease the number of relapses of the disease."

Answered by AI

Clinical Trials for Teriflunomide

Have you considered Teriflunomide clinical trials? We made a collection of clinical trials featuring Teriflunomide, we think they might fit your search criteria.
Have you considered Teriflunomide clinical trials? We made a collection of clinical trials featuring Teriflunomide, we think they might fit your search criteria.
Have you considered Teriflunomide clinical trials? We made a collection of clinical trials featuring Teriflunomide, we think they might fit your search criteria.
Unbiased ResultsWe believe in providing patients with all the options.
Your Data Stays Your DataWe only share your information with the clinical trials you're trying to access.
Verified Trials OnlyAll of our trials are run by licensed doctors, researchers, and healthcare companies.
Back to top