Multiple Sclerosis Clinical Trials
Here are the 6 most popular medical studies for multiple sclerosis
Monoclonal Antibodies
Ocrelizumab for Relapsing Multiple Sclerosis
This trial is testing whether a short course of treatment with a B-cell depleting antibody can have long-term effects in people with relapsing multiple sclerosis, and whether this is associated with normalization of a B-cell tolerance defect.
Popular filter options for multiple sclerosis trials
MS Clinical Trials
View 98 MS medical studies.
Central Nervous System Stimulant
Adderall XR for Cognitive Impairment in MS
This trial will compare the effects of two doses of Adderall XR (a mixed amphetamine salt, extended release medication) to placebo on measures of processing speed and memory in people with MS.
Procedure
Deep Brain Stimulation for Parkinson's Disease
This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.
Immunomodulator
Teriflunomide for Pediatric Multiple Sclerosis
This trial is testing whether the drug teriflunomide can help treat multiple sclerosis in children and adolescents. The trial will compare teriflunomide to a placebo, and will measure disease activity, brain MRI changes, and cognitive function.
Parkinson's Disease Clinical Trials
View 7 Parkinson's Disease medical studies.
Procedure
Deep Brain Stimulation for Parkinson's Disease
This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.
Behavioural Intervention
Movement-2-Music Exercise Program for Mobility Disabilities
This trial is testing the effects of an innovative exercise program, movement-2-music (M2M), on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants will be recruited and randomly enrolled into one of two groups: M2M or waitlist control. The primary aim of this study is to determine the effects of the 12-week M2M program on health and fitness in participants with physical/mobility disabilities. The study will also compare the observed effects of the program to a previous M2M study, and test whether adherence (attendance to the 12-week program) affects the
Phase 3 Multiple Sclerosis Clinical Trials
View 98 phase 3 multiple sclerosis medical studies.
Central Nervous System Stimulant
Adderall XR for Cognitive Impairment in MS
This trial will compare the effects of two doses of Adderall XR (a mixed amphetamine salt, extended release medication) to placebo on measures of processing speed and memory in people with MS.
Immunomodulator
Teriflunomide for Pediatric Multiple Sclerosis
This trial is testing whether the drug teriflunomide can help treat multiple sclerosis in children and adolescents. The trial will compare teriflunomide to a placebo, and will measure disease activity, brain MRI changes, and cognitive function.
Monoclonal Antibodies
High-Dose Ocrelizumab for Multiple Sclerosis
This trial is testing a higher dose of ocrelizumab, given every 24 weeks, to see if it is more effective than the current 600 mg dose, in people with RMS. The trial will also look at safety and how the body processes the drug.
Multiple Sclerosis Clinical Trials With No Placebo
View 98 multiple sclerosis medical studies that do not have a placebo group.
Procedure
Deep Brain Stimulation for Parkinson's Disease
This trial is testing different types of deep brain stimulation to see which is most effective in treating Parkinson's, essential tremor, and multiple sclerosis. The results will help design more effective stimulation patterns and aid in understanding how DBS works.
Behavioural Intervention
Computerized Cognitive Exercise Training for Multiple Sclerosis
This trial is testing a new computer-based treatment for cognitive impairment in people with multiple sclerosis, to see if it is better than a control computer-based treatment.
Behavioral Intervention
Fatigue Management Programs for Multiple Sclerosis
This trial is comparing 3 ways of delivering a course on reducing fatigue for people with MS. The goal is to see if the cheaper and easier versions are just as good as the in-person version.
Behavioural Intervention
Behavioral Intervention for Multiple Sclerosis
This trial will test whether a 6-month behavioral intervention, delivered online, can help people with MS increase their physical activity and improve their mobility, cognition, symptoms, and quality of life.
Paid Multiple Sclerosis Clinical Trials
View 98 multiple sclerosis medical studies that offer remuneration.
Leukocyte Tracking PET/MRI for Multiple Sclerosis
This trial will use PET/MRI to track white blood cells in people with conditions associated with brain inflammation. The hope is that by understanding neuroinflammation better, patients can be better diagnosed and treated in the future.
PET Radiopharmaceutical
DPA-714 PET/MRI for Chronic Pain and Fatigue
This trial is testing a new way to measure neuroinflammation in people with chronic pain and fatigue, which may be caused by neuroinflammation. The new method uses a PET tracer that binds to a protein in the mitochondria of activated microglia/macrophages. The trial will compare levels of neuroinflammation in patients and healthy controls.
F-18 3F4AP Imaging for Multiple Sclerosis
This trial is testing the safety and efficacy of using a new imaging agent, [18F]3F4AP, to visualize demyelinating diseases such as multiple sclerosis. The goal is to see if this agent can help assess disease severity and progression, and to see if it can help guide treatment decisions.
Behavioural Intervention
High-Fiber Supplement for Multiple Sclerosis
This trial will examine the effect of a specially designed high-fiber supplement on the growth of short-chain fatty acid-producing gut bacteria and development of regulatory immune cells in people with MS.
View More Multiple Sclerosis Trials
See another 67 medical studies focused on multiple sclerosis.
Frequently Asked Questions
Introduction to multiple sclerosis
What are the top hospitals conducting multiple sclerosis research?
When it comes to advancing treatment options for multiple sclerosis (MS), several hospitals across the United States are leading the way in groundbreaking clinical trials. In Cleveland, Ohio, the renowned Cleveland Clinic is actively involved in five ongoing MS trials and has an impressive track record of 26 completed trials since their first recorded endeavor in 2005. Meanwhile, in Oklahoma City, the Oklahoma Medical Research Foundation is making significant contributions with four active MS trials and a total of 11 completed studies since initiating their first trial in 2011.
In Chicago, Illinois, the University of Illinois at Chicago is also dedicated to pioneering new treatments for MS through its participation in four ongoing clinical trials. Their commitment dates back to 2003 when they conducted their initial trial on this complex neurological disorder.
Another prominent institution contributing to our understanding of MS is the National Institutes of Health Clinical Center located in Bethesda, Maryland. With four active clinical trials and a remarkable history involving 15 previous investigations dating all the way back to their first recorded trial on MS in 1992.
Lastly but not least important,the University of Texas Southwestern Medical Center situated Dallas takes pride into offering three current clinical tests while holding around thirteen former inquiries;theirs can be traced back only seventeen years ago where they initiated exploration into managing this condition from as early as year2004
These hospitals serve as beacons of hope for those affected by multiple sclerosis by pushing forward medical boundaries through innovative research initiatives. The collective efforts displayed by these institutions underscore our commitment towards finding better treatment options and ultimately improving quality of life for individuals living with this chronic autoimmune disease
Which are the best cities for multiple sclerosis clinical trials?
When it comes to multiple sclerosis clinical trials, several cities emerge as leading hubs for research and development. Philadelphia, Pennsylvania stands out with 17 active trials focusing on treatments like RPC-1063, Ocrelizumab, and BNT162b2. New york, New York follows closely behind with 15 ongoing studies exploring interventions such as Ocrelizumab and Bivalent + Continue IS (MTX). Additionally, Cleveland, Ohio hosts 11 active trials investigating treatments like RPC-1063 and Cohort B. These cities serve as centers of excellence in multiple sclerosis research, offering individuals affected by the condition access to innovative therapies that hold promise for improved outcomes.
Which are the top treatments for multiple sclerosis being explored in clinical trials?
Multiple sclerosis (MS) research is at the forefront of medical advancements, with several promising treatments currently under exploration in clinical trials. The leading contenders include:
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Ocrelizumab: Demonstrating its potential, ocrelizumab is involved in seven active trials and has been a part of 48 multiple sclerosis studies since it was first listed in 2008.
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HB-adMSCs: A newcomer on the scene, HB-adMSCs are being investigated in one ongoing trial for MS. This therapy shows great promise as it enters the world of clinical research.
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Phase 3; MYOBLOC: Another recent addition to the list, phase 3 MYOBLOC holds significant potential for treating multiple sclerosis. Currently engaged in one active trial, this treatment option warrants close attention from researchers and patients alike.
These cutting-edge therapies offer hope for individuals living with MS and highlight the continuous efforts made to find effective solutions against this complex neurological disorder.
What are the most recent clinical trials for multiple sclerosis?
Recent clinical trials offer promising prospects for individuals living with multiple sclerosis. One such trial focuses on Clemastine Fumarate, which has progressed to Phase 2 after successful results in Phase 1. Another study examines the effectiveness of PIPE-791 as a potential treatment option for multiple sclerosis patients following positive outcomes in its Phase 1 trial. Additionally, an ongoing Phase 2 trial is investigating a novel treatment arm specifically tailored for individuals with multiple sclerosis. These advancements bring hope and optimism to those affected by this debilitating condition, showcasing the dedication of researchers and medical professionals towards improving patient care and quality of life.
What multiple sclerosis clinical trials were recently completed?
In recent years, several clinical trials have concluded in their quest to advance the understanding and treatment options for multiple sclerosis (MS). Notable among them is a trial sponsored by the University of Utah which focused on MRI Brain and Cervical Spine, completed in June 2022. Additionally, Mapi Pharma Ltd.'s GA Depot trial finished in September 2019, followed closely by Columbia University's Aspirin 650mg Oral Capsule study which concluded in April of that same year. Other significant trials include Novartis Pharmaceuticals' Siponimod (February 2019), Biogen's Natalizumab (November 2018), Tisch Multiple Sclerosis Research Center of New york's Intrathecal MSC-NP injection (September 2018), and Johns Hopkins University's Tauroursodeoxycholic Acid research (June 2018). These collective efforts demonstrate ongoing dedication towards advancing treatments for individuals living with MS.