Multiple Sclerosis Clinical Trials 2022

Multiple Sclerosis studies recruiting patients for novel treatments. Filter by phase, distance, and inclusion criteria to find your perfect multiple sclerosis clinical trial in 2022.

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Impact of four week coaching program on dietary habits

The purpose of this study is to explore the effects of a four week diet coaching program on pain, fatigue, mood, and dietary habits among adults with multiple sclerosis.

This study is evaluating whether a treatment with stem cells might help people with multiple sclerosis.

eSupport Health Weekly Group Sessions for PwMS

This study is evaluating whether a support group can help people with multiple sclerosis.

Phase 2/3, randomized, double-blind, placebo-controlled, single-treatment, multicenter trial assessing the efficacy and safety of MYOBLOC for the treatment of upper limb spasticity in adults followed by an open-label extension safety trial.

This study is evaluating whether a drug called Mavenclad can help people with multiple sclerosis.

A safety study of ANK-700 in patients with relapsing remitting multiple sclerosis. The study has two parts: Part A - first in human study in which patients receive a single dose of ANK-700 Part B - patients will receive three doses of either ANK-700 or placebo

This study is evaluating whether nabiximols can help reduce muscle spasms in people with multiple sclerosis.

Transcranial Rotating Permanent Magnet Stimulator (TRPMS)

This study is evaluating whether brain centers are involved in initiating voiding in patients with neurogenic bladder dysfunction.

This study is evaluating whether a wearable robotic exoskeleton can help individuals with neurological conditions.

Prospective Memory Intervention

Up to 70% of persons with multiple sclerosis (PwMS) experience cognitive impairment, which can have a significant impact on several aspects of their daily lives. One cognitive domain that has been shown to impact daily functioning, but is understudied in MS, is prospective memory (PM). Whi…

This study is evaluating whether ocrelizumab is safe for breastfeeding women.

This study is evaluating whether minocycline can reduce the number of new brain lesions in people with multiple sclerosis.

behavioral telehealth

We will tailor a telehealth obesity intervention for obese patients with MS (figure 2). Half of the patients will be randomly assigned to 24 weekly hour-long group weight loss sessions and 6 monthly individual sessions; half will be assigned to a brief education/Treatment as Usual (TAU) co…

PMT/Blackrock Combination Device

This study is evaluating whether brain signals can be used to control devices for motor and speech control.

This study is evaluating whether ocrelizumab is effective in people with multiple sclerosis.

This study is evaluating whether a drug that improves blood flow in the brain can improve the way in which MS lesions evolve.

Communication with the clinic

This study is evaluating whether a questionnaire can be used to confirm a relapse has occurred.

non-invasive transcranial electrical stimulation

This study is evaluating whether non-invasive electrical stimulation can help improve cognition in individuals with multiple sclerosis.

This study is evaluating whether a drug may help treat multiple sclerosis.

The use of simulators to retrain driving skills of patients with stroke, Parkinson's disease (PD), or multiple sclerosis (MS) is very limited because of cost, space required, and incidence of simulator sickness in high fidelity simulators. The Principal investigator recently developed a lo…

Treadmill Walking Exercise Training

This study is evaluating whether exercise may help improve cognitive processing speed for individuals with multiple sclerosis.

Background: In people with multiple sclerosis (MS), brain and cerebrospinal fluid (CSF) biomarkers indicate inflammation or disease. Researchers want to see if 4 drugs given alone or combined affect MS biomarkers. They want to see if a change in biomarker levels can predict which drugs a …

The purpose of this research study is to compare the effects of cannabidiol (CBD), tetrahydrocannabinol (THC), or both, on sleep and pain in persons with multiple sclerosis (MS). Little is known about how CBD and/or THC may help sleep, reduce pain, or perhaps even treat pain through better…

Conscientiousness Coach

This study is evaluating whether a phone app can help people with their health management and employment.

This study is evaluating whether a treatment that increases muscle tension and stretch in the spine and lower extremities can improve movement and function in people with MS.

This study is evaluating whether a biomarker can be used to detect changes in the brain that may be associated with MS.

Proximal Resistance Training

This study is evaluating whether a new exercise program may help improve walking ability for individuals with multiple sclerosis.

This study is evaluating whether a tool which helps older adults decide whether to continue driving may help improve their quality of life.

Fecal microbial transplant (FMT)

This study is evaluating whether fecal microbial transplantation may be an effective treatment for multiple sclerosis.

This study is evaluating whether a brain scan can be used to determine if a person is receiving a placebo or an active treatment.

This study is evaluating whether a drug called RPC1063 is safe and effective in treating people with relapsing multiple sclerosis.

Therapeutic Stimulation Patterns

This study is evaluating whether non-regular patterns of deep brain stimulation can improve symptoms in people with Parkinson's disease, essential tremor, or multiple sclerosis.

Multicenter, Randomized, Double-blind, Placebo-controlled Study to Evaluate Efficacy, Safety, and Tolerability of IMU-838 in Patients with Progressive Multiple Sclerosis - CALLIPER

Our overall objective is to obtain an initial assessment of the potential value of using [18F]3F4AP for imaging demyelinating diseases such as multiple sclerosis: Aim 1) Assess the safety of [18F]3F4AP in healthy volunteers and subjects with multiple sclerosis (MS). Hypothesis 1: Administ…

This study is evaluating whether a higher dose of a drug may help people with primary progressive multiple sclerosis.

CBT for Uncertainty Tolerance

This study is evaluating whether a brief, telephone-based psychological intervention may help reduce distress in people with a recent diagnosis of multiple sclerosis.

This study is evaluating whether two non-pharmacological treatments can help decrease pain and other outcomes (e.g., sleep, fatigue) in persons with multiple sclerosis.

This study is evaluating whether a drug may help reduce the frequency of relapses in individuals with multiple sclerosis.

Intrathecal MSC-NP injection

This study is evaluating whether multiple intrathecal injections of autologous mesenchymal stem cell-derived neural progenitor cells (MSC-NP) can improve disability in people with progressive multiple sclerosis.

This study is evaluating whether ponesimod is safe and effective for people with relapsing multiple sclerosis.

The purpose of this study is to compare the effects of two delivery models of an evidence-based complementary alternative medicine (CAM) program that combines neurorehabilitative (functional) exercise, yoga, and Pilates for adults age 18-70 with multiple sclerosis (MS). CAM will be deliver…

Blood Flow Restriction

This research is being done to compare the current standard of care for strength training for patients with Multiple Sclerosis to lightweight resistance training with blood flow restriction.

This study is evaluating whether a virtual seated physical intervention can improve cardiovascular health and wellness in people with chronic neurological impairments.

Body-weight supported treadmill training in a room cooled to 16°C

This study is evaluating whether a vigorous intensity cool room treadmill training program can improve fatigue and heat sensitivity in people with multiple sclerosis.

This is a randomized controlled trial of the Assistive Device Selection, Training, and Education Program (ADSTEP). ADSTEP is a training program of six weekly one-on-one sessions with a physical therapist intended to reduce falls among people who use a hand-held walking aid, such as a cane …

This study is evaluating whether bright light therapy can improve sleep quality in people with multiple sclerosis.

The purpose of this study is to test the effects of an innovative exercise program referred to as movement-2-music (M2M) on health and fitness outcomes in adults with physical/mobility disabilities. One hundred and eight participants with physical/mobility disabilities will be recruited an…

Early order of palliative care consultation

This study is evaluating whether palliative care consultations should be done in the emergency department or later in the hospital.

Background: Multiple sclerosis (MS) affects the brain, spinal cord, and optic nerves. MS lesions can appear on the MRI (magnetic resonance imaging) scans in many ways. Sometimes they light up from the outer edge and fill inward. This is called ring enhancement. Researchers think this type…

The clinical trial is intended to assess for clinical evidence of Clemastine Fumarate as a myelin repair therapy in patients with chronic inflammatory injury-causing demyelination as measured by multi-parametric MRI assessments. No reparative therapies exist for the treatment of multiple …

This study is evaluating whether a single dose of a stem cell product can improve symptoms in people with multiple sclerosis.

This is a multicenter, longitudinal, single-arm, open-label study to describe the change from baseline in cognitive processing speed, measured by the SDMT, in subjects with RMS treated with ozanimod HCl 1 mg at 3 years. All subjects will receive orally administered ozanimod HCl 1 mg. The …

Background: Multiple sclerosis (MS) is a disease of the central nervous system (CNS). People who have MS may have lesions that form on parts of the CNS, such as the brain. Some of these lesions may be inflamed for a long time. This causes MS to progress. There is no treatment for these le…

This study is evaluating whether medical cannabis may help treat chronic medical conditions.

This study is evaluating whether a radioactive tracer can be used to measure neuroinflammation in individuals with chronic pain and fatigue.

Computerized cognitive rehabilitation

This study is evaluating whether a computerized cognitive rehabilitation intervention is effective in improving cognitive function in adults with multiple sclerosis.

Remotely Delivered and Supported Aerobic Walking Exercise Training

Cognitive processing speed (CPS) impairment is prevalent, impactful, and poorly-managed in multiple sclerosis (MS). Upwards of 67% of patients present with MS-related CPS impairment, which is associated with poor everyday life outcomes. There are no FDA-approved pharmacological treatments …

This study is evaluating whether a set of activities can improve physical activity in people with multiple sclerosis.

This study is evaluating whether ocrelizumab can be transferred to the fetus.

This study is evaluating whether a drug called SAR441344 can reduce the number of new brain lesions in people with MS.

XYOSTED 75 milligram (mg) in 0.5 ML Auto-Injector

This study is evaluating whether testosterone treatment may help improve symptoms in men with multiple sclerosis.

The primary goal of this study is to assess the efficacy of bazedoxifene (BZA) as remyelinating agent in patients with relapsing-remitting multiple sclerosis (RRMS). The investigators will utilize electrophysiologic techniques and magnetic resonance imaging to quantify the effect of treat…

Lifestyle Physical Activity

This study is evaluating whether a lifestyle physical activity intervention can improve fitness and vascular comorbidity risk in people with MS.

This study is evaluating whether lipoic acid may help preserve mobility and protect the brain in progressive forms of multiple sclerosis.

A Phase I Study of NeuroVax™, a Novel Therapeutic TCR Peptide Vaccine for Pediatric Multiple Sclerosis to demonstrate safety & efficacy

This study is evaluating whether a vaccine booster dose might improve immune response to a COVID-19 vaccine in people with autoimmune disease.

This study is evaluating whether a drug called Lu AG06466 can help reduce spasticity in people with multiple sclerosis.

Blood Flow Restriction Exercise

This study is evaluating whether a new type of physical therapy may help improve walking ability for individuals with multiple sclerosis.

It has been suggested that dysbiosis of gut commensal bacteria increases the risk of autoimmune diseases including MS. However, there is no viable intervention available to correct dysbiosis. Since high-fiber supplement can promote the growth of healthy bacteria in the gut, the investigato…

The purpose of this study is to explore the safety, tolerability and activity of Nivolumab, a PD-1 inhibitor, in cohorts of patients with autoimmune disease. Two cohorts of patients will be enrolled, based on autoimmune disease type. Patients will be screened within 28 days prior to the s…

This study is evaluating whether a behavioral intervention may help improve physical activity and quality of life for individuals with multiple sclerosis.

This study is evaluating whether a surgery which reduces blood flow in a stomach artery leads to significant weightloss.

Spasticity Take Control

This study is evaluating whether two different methods of managing MS-related spasticity of the lower limbs will have positive impacts.

PACR (Plasticity-based, Adaptive, Computerized Cognitive Remediation)

This study is evaluating whether a computer-based cognitive remediation program can improve cognitive functioning in people with multiple sclerosis.

This is a Phase IIIb, single-arm, multicenter, OLE study. Participants receiving ocrelizumab as an investigational medicinal product (IMP) in a Roche sponsored Parent study who continue to receive ocrelizumab or are in safety follow-up at the time of the closure of their respective Parent …

Forced Aerobic Exercise (FE)

This study is evaluating whether aerobic exercise may help improve mobility for individuals with multiple sclerosis.

This study is evaluating whether aerobic exercise may help improve the myelin sheath in individuals with multiple sclerosis.

This study is evaluating whether a new pain management program may help individuals with chronic pain.

This study is evaluating whether an arts-based health education program can improve health and well-being.

Physical Activity (PA)

This study is aimed to test the efficacy of transcranial direct current stimulation (tDCS) combined with a physical activity (PA) program, in 80 individuals affected by Multiple Sclerosis (MS). In particular, this study will evaluate the efficacy of tDCS when administered simultaneously wi…

This study is evaluating whether a new imaging technique can help detect early signs of neurodegenerative diseases.

This study is evaluating whether a combination of cognitive training and transcranial direct current stimulation may help improve cognitive abilities for individuals with traumatic brain injury.

Immediate Autoimmune Intervention Mastery Course (AIM)

The goal of this project is to critically evaluate the effectiveness of using an online program to improve diet and self-care in patients with multiple sclerosis (MS) and clinically isolated syndrome (CIS).

Transcranial Direct Current Stimulation (tDCS)