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Mitochondrial-targeted antioxidant

MitoQ for Multiple Sclerosis (MitoQ Trial)

Phase 1 & 2
Recruiting
Led By Vijayshree Yadav, MBBS
Research Sponsored by VA Office of Research and Development
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Complaint of fatigue that has been persistent for at least two months
MS (any clinical subtype) as diagnosed by the 2017 McDonald criteria
Timeline
Screening 3 weeks
Treatment Varies
Follow Up 12 weeks
Awards & highlights

MitoQ Trial Summary

This trial will test if a drug called MitoQ can help reduce fatigue in MS patients.

Who is the study for?
This trial is for MS patients with persistent fatigue and an MFIS score of 38 or higher. They must have been diagnosed by the McDonald criteria, have an EDSS score between 2 to 8, and not be severely depressed. People can't join if they've used steroids recently, are pregnant/breastfeeding, have certain health issues like heart or liver disease, or were on MitoQ/CoQ10 in the last month.Check my eligibility
What is being tested?
The study tests if MitoQ reduces fatigue in MS patients compared to a placebo. Participants will either take a daily dose of MitoQ (20mg or 40mg) or a placebo for 12 weeks. Their levels of fatigue at the start and after treatment will show if there's any improvement.See study design
What are the potential side effects?
Possible side effects aren't specified here but generally could include digestive discomforts, headaches, dizziness, skin reactions or other symptoms depending on how individuals react to MitoQ.

MitoQ Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I have been feeling tired for at least two months.
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I have been diagnosed with multiple sclerosis according to the 2017 criteria.
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My disability score is between 2 and 8.

MitoQ Trial Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~12 weeks
This trial's timeline: 3 weeks for screening, Varies for treatment, and 12 weeks for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Modified Fatigue Inventory Scale (MFIS)
Secondary outcome measures
Beck's Depression Inventory (BDI)
Expanded Disability Status Scale (EDSS)
Symbol Digit Modalities Test (SDMT)

MitoQ Trial Design

3Treatment groups
Active Control
Placebo Group
Group I: 20mg of MitoQActive Control1 Intervention
20mg of oral mitoquinol
Group II: 40mg of MitoQActive Control1 Intervention
40mg of Oral Mitoquinol
Group III: PlaceboPlacebo Group1 Intervention
Placebo

Find a Location

Who is running the clinical trial?

VA Office of Research and DevelopmentLead Sponsor
1,610 Previous Clinical Trials
3,305,124 Total Patients Enrolled
15 Trials studying Multiple Sclerosis
1,138 Patients Enrolled for Multiple Sclerosis
Vijayshree Yadav, MBBSPrincipal InvestigatorVA Portland Health Care System, Portland, OR

Media Library

MitoQ (Mitochondrial-targeted antioxidant) Clinical Trial Eligibility Overview. Trial Name: NCT04267926 — Phase 1 & 2
Multiple Sclerosis Research Study Groups: Placebo, 20mg of MitoQ, 40mg of MitoQ
Multiple Sclerosis Clinical Trial 2023: MitoQ Highlights & Side Effects. Trial Name: NCT04267926 — Phase 1 & 2
MitoQ (Mitochondrial-targeted antioxidant) 2023 Treatment Timeline for Medical Study. Trial Name: NCT04267926 — Phase 1 & 2

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Could I be a suitable participant in this experiment?

"To participate in this medical trial, those with multiple sclerosis and aged between 18 to 70 years of age are eligible. A maximum of 60 patients can join the study."

Answered by AI

Are individuals of all ages being considered for participation in this medical experiment?

"According to the prerequisites of this clinical test, participants must be at least 18 years old and no older than 70."

Answered by AI

How many individuals have taken part in the research?

"Correct. The information hosted on clinicaltrials.gov asserts that this medical trial, which was originally posted in April 1st 2020, is currently looking for participants to join the study. In total 60 patients will be recruited from one location."

Answered by AI

Is this research endeavor actively recruiting participants at the moment?

"Affirmative. According to information hosted on clinicaltrials.gov, this investigation is actively seeking volunteers for enrollment. It was first published in April 1st 2020 and has been recently updated on April 15th 2022; with the aim of finding 60 participants from one medical centre."

Answered by AI

Who else is applying?

How old are they?
18 - 65
What site did they apply to?
VA Portland Health Care System, Portland, OR
What portion of applicants met pre-screening criteria?
Met criteria
Recent research and studies
clinicaltrials.govStudy
MitoQ for Fatigue in Multiple Sclerosis (MS)
2020. "MitoQ for Fatigue in Multiple Sclerosis (MS)". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04267926.
All > Amyotrophic Lateral Sclerosis > Multiple Sclerosis
~5 spots leftby Sep 2024
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