Benzoyl Peroxide for Herpes Simplex
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial aims to test whether Benzoyl Peroxide, a common acne treatment, can prevent cold sores (oral lesions) caused by the Herpes Simplex Virus Type 1 (HSV-1). Participants will apply either Benzoyl Peroxide or a placebo (a substance with no active medicine) to determine which is more effective at stopping cold sore outbreaks. This study suits those who frequently experience cold sores and can participate in telehealth visits. The goal is to assess if Benzoyl Peroxide could offer a new, simple way to manage these outbreaks. As a Phase 2 trial, this research measures the treatment's effectiveness in an initial, smaller group, allowing participants to contribute to potential new solutions for cold sore management.
Do I have to stop taking my current medications for the trial?
The trial information does not specify whether you need to stop taking your current medications. It's best to discuss this with the trial organizers or your doctor.
Is there any evidence suggesting that Benzoyl Peroxide is likely to be safe for humans?
Research has shown that Benzoyl Peroxide is usually safe for skin application. Although often used to treat acne, this clinical trial tests its potential to prevent cold sores caused by Herpes Simplex Virus Type 1 (HSV-1).
Specific safety information from past studies on its use for HSV-1 is lacking, but Benzoyl Peroxide is commonly used in other skin treatments. Some individuals might experience mild side effects such as redness, peeling, or dryness of the skin. These effects are generally not serious and often decrease with continued use.
This trial is in Phase 2, indicating that Benzoyl Peroxide has already passed initial safety tests. Phase 2 trials focus more on the treatment's effectiveness while still closely monitoring safety. If Benzoyl Peroxide were unsafe, it would not have reached this phase. This trial aims to provide more information about its safety and effectiveness specifically for HSV-1.12345Why do researchers think this study treatment might be promising?
Unlike the standard treatments for herpes simplex, which typically involve antiviral medications like acyclovir or valacyclovir, benzoyl peroxide offers a unique approach. Benzoyl peroxide is known for its antibacterial properties and is commonly used in acne treatments, but its potential to disrupt the viral environment and reduce lesion severity in herpes is what sets it apart. Researchers are excited about this treatment because it represents a novel topical solution that could potentially work faster and provide relief without relying on traditional antiviral mechanisms.
What evidence suggests that Benzoyl Peroxide might be an effective treatment for HSV-1?
Research has shown that Benzoyl Peroxide might help prevent the recurrence of cold sores, which are caused by the Herpes Simplex Virus Type 1 (HSV-1). This trial tests whether a cream with 10% Benzoyl Peroxide, given to participants in the active treatment arm, can delay or stop outbreaks compared to a placebo cream with no active ingredient, given to participants in the placebo arm. An interesting case involved someone with HSV-2 (genital herpes) who experienced improvement using Benzoyl Peroxide, suggesting it might work on similar viruses. The main goal is to determine if Benzoyl Peroxide can reduce the frequency and severity of cold sores. Early results are promising, but more information is needed to confirm its effectiveness.16789
Who Is on the Research Team?
David Dinn, DMSc
Principal Investigator
Erroll McCoy
Are You a Good Fit for This Trial?
This trial is for people who often get cold sores from Herpes Simplex Virus Type 1 (HSV-1). Participants must be able to attend telehealth visits. The study excludes individuals based on specific criteria not listed here.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive either Benzoyl Peroxide 10% cream or placebo, applied twice daily at the onset of HSV-1 symptoms for up to 14 days
Follow-up
Participants are monitored for HSV-1 outbreak recurrence, lesion severity, and treatment satisfaction
Rescue Crossover
Placebo group participants experiencing recurrence receive Benzoyl Peroxide 10% cream
What Are the Treatments Tested in This Trial?
Interventions
- Benzoyl Peroxide
Find a Clinic Near You
Who Is Running the Clinical Trial?
Greg Bew
Lead Sponsor