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What is Apokyn
ApomorphineThe Generic name of this drug
Treatment SummaryApomorphine is an FDA-approved medication used to improve the mobility of people with Parkinson's disease. It was first synthesized in 1845 and has been used to treat a variety of other movement disorders, such as emesis, sedation, alcoholism, and more. Apomorphine was approved by the FDA in 2004.
Apokynis the brand name
Apokyn Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Apokyn
Apomorphine
2004
16
Approved as Treatment by the FDA
Apomorphine, otherwise called Apokyn, is approved by the FDA for 3 uses including Parkinson's Disease (PD) and Mobility decreased .Parkinson's Disease (PD)
Mobility decreased
Parkinson's Disease
Effectiveness
How Apokyn Affects PatientsApomorphine is a drug that helps control movement in the body. It has a short duration of action and is considered safe, although large overdoses can be toxic. Common side effects of the drug include nausea, vomiting, drowsiness, low blood pressure, irritation of the mouth, falls, hallucinations, psychotic-like behavior, and an increased risk for seizures. To help reduce the risk of nausea and vomiting, it is recommended to take a medication called trimethobenzamide three days before starting apomorphine and for no more than two months.
How Apokyn works in the bodyApomorphine is a medication that works by stimulating certain dopamine receptors in the brain. It binds to three different types of dopamine receptors, located in an area of the brain responsible for movement control. We don't know exactly how this affects people with Parkinson's disease, but it is thought to help improve mobility.
When to interrupt dosage
The proposed portion of Apokyn hinges on the diagnosed condition. The dosage also fluctuates based on the method of delivery (e.g. Kit - Sublingual or Liquid - Subcutaneous) as detailed in the table beneath.Condition
Dosage
Administration
Parkinson's Disease
, 30.0 mg/mL, 10.0 mg, 10.0 mg/mL, 15.0 mg, 25.0 mg, 30.0 mg, 20.0 mg
, Subcutaneous, Injection, Injection - Subcutaneous, Solution, Solution - Subcutaneous, Liquid, Liquid - Subcutaneous, Film, soluble, Kit - Sublingual, Sublingual, Film, soluble - Sublingual, Kit
Mobility decreased
, 30.0 mg/mL, 10.0 mg, 10.0 mg/mL, 15.0 mg, 25.0 mg, 30.0 mg, 20.0 mg
, Subcutaneous, Injection, Injection - Subcutaneous, Solution, Solution - Subcutaneous, Liquid, Liquid - Subcutaneous, Film, soluble, Kit - Sublingual, Sublingual, Film, soluble - Sublingual, Kit
Warnings
Apokyn ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Common Apokyn Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The metabolism of Amiodarone can be decreased when combined with Apomorphine.
Astemizole
Major
The metabolism of Astemizole can be decreased when combined with Apomorphine.
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Apomorphine.
Azelastine
Major
Apomorphine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Brigatinib
Major
The metabolism of Brigatinib can be decreased when combined with Apomorphine.
Apokyn Toxicity & Overdose RiskThose who overdose on apomorphine may experience nausea, low blood pressure, and loss of consciousness. Treatment involves providing supportive care. Tests have found the lowest toxic dose of apomorphine in mice to be 145µg/kg.
Apokyn Novel Uses: Which Conditions Have a Clinical Trial Featuring Apokyn?
45 active trials are presently looking into the potential of Apokyn to treat Parkinson's Disease.Condition
Clinical Trials
Trial Phases
Parkinson's Disease
39 Actively Recruiting
Not Applicable, Phase 1, Phase 4, Phase 2, Phase 3, Early Phase 1
Mobility decreased
0 Actively Recruiting
Apokyn Reviews: What are patients saying about Apokyn?
4.7Patient Review
7/1/20094.3Patient Review
9/6/2013 My husband's gambling addiction has put us in a tough financial situation. He can't work because of it and I don't know if we'll be able to make ends meet.
3.7Patient Review
6/26/2017 This drug is effective and works quickly, however I wish it had a longer lasting effect.
2.7Patient Review
2/4/2010 Apokyn is much more effective than other oral PD medications I've tried. Usually, the effects kick in within 15 minutes.
2Patient Review
4/23/2012 I run a support group and am very disappointed with how expensive this medication is. A person on disability can't even afford it, and that's with insurance. When something works, they price it beyond our means.
Patient Q&A Section about apokyn
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is APOKYN a controlled substance?
"No, Apokyn is not a controlled substance."
Answered by AI
Is APOKYN a dopamine agonist?
"Apokyn helps to treat episodes of muscle stiffness and loss of muscle control in people with advanced Parkinson's disease by restoring the balance of dopamine in the brain."
Answered by AI
How much does APOKYN cost per month?
"The Apokyn coupon & prices make it affordable for anyone to get the help they need to manage their condition. The cost is $49 per month, which is a fraction of the cost of most other medications."
Answered by AI
What is APOKYN used for?
"APOKYN is used to treat an advanced symptom of Parkinson's disease known as hypomobility, or "off episodes." This can cause muscle stiffness, slow movements, and difficulty starting movements."
Answered by AI
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