Syprine
Hepatolenticular Degeneration
Treatment
2 FDA approvals
3 Active Studies for Syprine
Treatment for
Hepatolenticular Degeneration
What is Syprine
Triethylenetetramine
The Generic name of this drug
Treatment Summary
Triethylenetatramine (TETA) is a medication used to treat copper overload in the body. It was introduced in 1969 as an alternative to D-penicillamine and is different from penicillamine because it does not contain sulfhydryl groups. In 1985, it was approved by the FDA as a second-line therapy for Wilson's disease. Although penicillamine treatment is more widely used, TETA has been shown to be an effective initial therapy, even with patients with severe liver disease. TETA therapy is not associated with the same adverse effects as penicillamine treatment and is being
Syprine
is the brand name
Syprine Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Syprine
Triethylenetetramine
1985
21
Approved as Treatment by the FDA
Triethylenetetramine, commonly known as Syprine, is approved by the FDA for 2 uses including Wilsons Disease and Hepatolenticular Degeneration .
Wilsons Disease
Helps manage Wilsons Disease
Hepatolenticular Degeneration
Helps manage Wilsons Disease
Effectiveness
How Syprine Affects Patients
Triethylenetetramine (TETA) is a medicine that helps the body remove excess copper. It has been used to treat Wilson's disease, a disorder caused by too much copper in the body. In some studies, it has been found to reduce enlargement of the heart in humans and animals with diabetes, and to reverse some of the damage caused by diabetes in the kidneys. Additionally, it is thought to have anti-cancer properties by blocking the growth of new blood vessels in cancer cells and reducing the activity of cancer-causing enzymes.
How Syprine works in the body
Wilson's disease is a genetic disorder that causes too much copper to build up in the body. To treat this, doctors prescribe a copper-chelating agent called triethylenetetramine (TETA). This binds to the copper and makes it easier for the body to get rid of it. TETA also reduces how much copper the body absorbs from food. It can also bind to other minerals like iron, zinc, magnesium, and manganese.
When to interrupt dosage
The recommended amount of Syprine is contingent upon the diagnosed state. The dose fluctuates, in line with the method of administration demonstrated in the table beneath.
Condition
Dosage
Administration
Hepatolenticular Degeneration
250.0 mg, , 200.0 mg, 150.0 mg
Oral, , Capsule, Capsule - Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, gelatin coated - Oral, Capsule, gelatin coated
Warnings
Syprine has one contraindication and should not be used in combination with the conditions specified in the following table.
Syprine Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Triethylenetetramine may interact with Pulse Frequency
There are 20 known major drug interactions with Syprine.
Common Syprine Drug Interactions
Drug Name
Risk Level
Description
Technetium Tc-99m oxidronate
Major
Triethylenetetramine may decrease effectiveness of Technetium Tc-99m oxidronate as a diagnostic agent.
Aclidinium
Minor
Triethylenetetramine may decrease the excretion rate of Aclidinium which could result in a higher serum level.
Acrivastine
Minor
Triethylenetetramine may decrease the excretion rate of Acrivastine which could result in a higher serum level.
Albutrepenonacog alfa
Minor
Triethylenetetramine may decrease the excretion rate of Albutrepenonacog alfa which could result in a higher serum level.
Ancestim
Minor
Triethylenetetramine may decrease the excretion rate of Ancestim which could result in a higher serum level.
Syprine Toxicity & Overdose Risk
The toxic dose of trientine in rats has been found to be 2500mg/kg orally and 550mg/kg through the skin. In occasional cases, an overdose of trientine can cause nausea, vomiting, dizziness, kidney damage, low levels of phosphorus and zinc, and low levels of copper in the blood. Treatment for trientine overdose is usually supportive measures and intravenous hydration. There is currently no antidote for trientine overdose. Prolonged use of high doses of trientine can lead to a type of anemia involving abnormal red blood cells.
Syprine Novel Uses: Which Conditions Have a Clinical Trial Featuring Syprine?
5 active clinical trials are in progress to assess the efficacy of Syprine in managing Wilsons Disease.
Condition
Clinical Trials
Trial Phases
Hepatolenticular Degeneration
3 Actively Recruiting
Not Applicable, Phase 1, Phase 2
Syprine Reviews: What are patients saying about Syprine?
4.3
Patient Review
9/22/2010
Syprine for Excessive Copper Deposits in the Liver and Brain
3.3
Patient Review
4/21/2011
Syprine for Excessive Copper Deposits in the Liver and Brain
3
Patient Review
9/28/2007
Syprine for Excessive Copper Deposits in the Liver and Brain
Patient Q&A Section about syprine
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
What is Syprine used for?
"Trientine hydrochloride, marketed as Syprine, is used to treat Wilson's disease in patients who are unable to take the medication penicillamine. Wilson's disease is a condition in which the body stores too much copper."
Answered by AI
How much does Syprine cost?
"The average price of Syprine is $25,520.16, but you can pay as little as $1,898.91 with a SingleCare Syprine free coupon."
Answered by AI
Is there a generic for Syprine?
"Trientine, also known as Syprine, is a medication that is available in generic form and may be significantly cheaper compared to the brand version."
Answered by AI
Who manufactures Syprine?
"price of the drug was raised to $21,267"
Answered by AI