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What is Clemastine Fumarate
ClemastineThe Generic name of this drug
Treatment SummaryDiphenhydramine is an antihistamine medication used to treat various allergies, such as hay fever, rhinitis, and skin allergies. It can also help relieve itching. This drug has a sedative effect, making users feel sleepy.
Clemastine Fumarateis the brand name
Clemastine Fumarate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clemastine Fumarate
Clemastine
1992
26
Approved as Treatment by the FDA
Clemastine, also known as Clemastine Fumarate, is approved by the FDA for 3 uses including Catarrh and Angioedema .Catarrh
Angioedema
Hives
Effectiveness
How Clemastine Fumarate Affects PatientsClemastine is an antihistamine that can also cause drowsiness and block certain effects of histamine in the body. Histamine affects the blood vessels by making them widen or contract, and clemastine helps to reverse these effects. It does this by blocking the receptors that histamine would normally attach to. Clemastine does not actually stop histamine from being released or change how it works in the body, but it helps to prevent the effects of histamine from happening.
How Clemastine Fumarate works in the bodyClemastine is a drug that blocks the effects of histamine in the body. Histamine can cause itching, sneezing, watery eyes, and other uncomfortable symptoms. Clemastine stops this from happening by attaching to the histamine receptor and blocking its action. This brings temporary relief from histamine-related symptoms.
When to interrupt dosage
The prescribed dosage of Clemastine Fumarate is contingent upon the diagnosed affliction, such as Hay Fever, Hives and Catarrh. The amount of dosage shifts as per the method of administration detailed in the table below.Condition
Dosage
Administration
Catarrh
1.34 mg, , 2.68 mg, 0.5 mg/mL, 1.0 mg, 0.67 mg/mL
, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral
Angioedema
1.34 mg, , 2.68 mg, 0.5 mg/mL, 1.0 mg, 0.67 mg/mL
, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral
Hives
1.34 mg, , 2.68 mg, 0.5 mg/mL, 1.0 mg, 0.67 mg/mL
, Oral, Tablet, Tablet - Oral, Syrup, Syrup - Oral, Tablet, extended release, Tablet, extended release - Oral
Warnings
Clemastine Fumarate ContraindicationsCondition
Risk Level
Notes
Pulse Frequency
Do Not Combine
treating lower respiratory tract symptoms
Do Not Combine
Common Clemastine Fumarate Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Clemastine is combined with Amiodarone.
Amoxapine
Major
The metabolism of Amoxapine can be decreased when combined with Clemastine.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Clemastine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Clemastine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Clemastine is combined with Asenapine.
Clemastine Fumarate Toxicity & Overdose RiskThe toxic dose of antihistamine in rats is 3550mg/kg and 730mg/kg in mice. Overdosing on antihistamine can cause different reactions in children and adults. In children, it may cause excitement, hallucinations, muscle twitching, fever, and convulsions. Adults may experience drowsiness and coma. Other common symptoms include dry mouth, large pupils, flushed face, and fever.
Clemastine Fumarate Novel Uses: Which Conditions Have a Clinical Trial Featuring Clemastine Fumarate?
39 active clinical trials are assessing the potential of Clemastine Fumarate to alleviate the symptoms of Hay Fever, Catarrh and Angioedema.Condition
Clinical Trials
Trial Phases
Hives
17 Actively Recruiting
Early Phase 1, Phase 3, Phase 4, Phase 2, Phase 1
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
Angioedema
14 Actively Recruiting
Phase 2, Phase 3, Phase 1
Clemastine Fumarate Reviews: What are patients saying about Clemastine Fumarate?
5Patient Review
12/10/2018 Clemastine fumarate (brand name Tavist) is really the best product for my itchy eyes. I've tried everything else on the market, and nothing comes close to its effectiveness. The only downside is that it's hard to find; hopefully, it won't be taken off the market anytime soon!
5Patient Review
1/6/2014 This medication has allowed me to eat gluten again without any adverse effects for the past several months.
5Patient Review
8/20/2010 If you're looking for something more sedating than Claritin or Zyrtec, this is a good option to consider during severe allergy seasons.
Patient Q&A Section about clemastine fumarate
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.What does clemastine treat?
"Clemastine is an antihistamine that is used to relieve symptoms associated with hay fever, allergies, and hives such as sneezing, runny nose, red eyes, and swelling."
Answered by AI
Why is clemastine fumarate unavailable?
"Tavist-D is a combination of two drugs: clemastine (an antihistamine) and phenylpropanolamine (a decongestant). Some years ago, phenylpropanolamine was taken off the market because using it carried an increased risk of hemorrhagic stroke."
Answered by AI
What is the brand name for clemastine?
"Clemastine is a medication that is available in different forms, such as tablets and syrup. Many generic forms of this medication do not require a prescription. Some of the common brand names for this medication include Tavist Allergy and Dayhist Allergy."
Answered by AI
Is clemastine fumarate over the counter?
"Clemastine Fumarate Tablets belongs to a class of drugs called antihistamines.
This medicine is used to treat the symptoms of nasal allergies, sneezing, runny nose, itching, and watery eyes. It may be used alone or with other medications. This medicine belongs to a class of drugs called antihistamines."
Answered by AI