Brain Stimulation + Language Therapy for Aphasia
(TaMS Trial)
What You Need to Know Before You Apply
What is the purpose of this trial?
This trial tests a new approach to help stroke survivors with aphasia (difficulty finding words) improve their language skills. Researchers combine a brain treatment called transcranial magnetic stimulation (TMS) with a type of language therapy to determine if it enhances word-finding abilities. The trial includes two groups: one receiving precision TMS and the other a control version, both followed by the same language therapy, Semantic Feature Analysis (SFA). Individuals who have had a left hemisphere stroke, speak English, and do not have severe cognitive or sensory issues might be suitable candidates.
As an unphased trial, this study provides a unique opportunity to contribute to innovative research that could enhance language recovery strategies for stroke survivors.
Do I have to stop taking my current medications for the trial?
The trial information does not specify if you need to stop taking your current medications. However, if you are on pro-convulsant medications or have untreated conditions that could lower seizure thresholds, you may not be eligible to participate.
What prior data suggests that this brain stimulation and language therapy protocol is safe for stroke survivors with aphasia?
Research has shown that using transcranial magnetic stimulation (TMS) with language therapy is generally safe for people recovering from strokes. One study used TMS for six months and found it improved speech in individuals with post-stroke aphasia without causing major side effects. Another study also found that TMS can safely enhance speech abilities, particularly in understanding spoken words.
Although researchers continue to study TMS, these findings suggest it is well-tolerated. Participants in previous studies did not report significant negative effects. This makes TMS a promising option for improving language skills in stroke survivors with aphasia.12345Why are researchers excited about this trial's treatments?
Researchers are excited about the combination of brain stimulation and language therapy for aphasia because it offers a fresh approach compared to traditional speech therapy alone. Unlike standard treatments, this method uses transcranial magnetic stimulation (TMS) to potentially enhance brain function, followed by Semantic Feature Analysis (SFA) to improve language skills. The precision TMS aims to specifically target and stimulate areas of the brain responsible for language, which might lead to more effective and quicker improvements in speech and communication abilities. This dual approach could offer hope for those with aphasia seeking more rapid and significant recovery outcomes.
What evidence suggests that this trial's treatments could be effective for improving word-finding abilities in stroke survivors with aphasia?
This trial will compare two approaches: Precision TMS with SFA and Control TMS with SFA. Research has shown that transcranial magnetic stimulation (TMS) combined with language therapy can help people with aphasia improve their language skills. One study found that TMS had both immediate and long-lasting effects on language recovery in stroke survivors with aphasia. Another study showed that TMS helped patients with aphasia score better on language tests, indicating clear improvements. Additionally, TMS has shown promise in other language-related conditions, suggesting it could benefit aphasia treatment. Overall, evidence supports that combining TMS with language therapy can enhance word-finding abilities in those recovering from a stroke.13678
Are You a Good Fit for This Trial?
This trial is for stroke survivors who struggle with word-finding due to aphasia, a language disorder. Specific eligibility details are not provided, but typically participants must meet certain health criteria and not have conditions that would exclude them from safely participating in the study.Inclusion Criteria
Exclusion Criteria
Timeline for a Trial Participant
Screening
Participants are screened for eligibility to participate in the trial
Treatment
Participants receive excitatory TMS combined with SFA language therapy
Follow-up
Participants are monitored for changes in picture naming accuracy after treatment
What Are the Treatments Tested in This Trial?
Interventions
- Control TMS with SFA
- Precision TMS with SFA
Find a Clinic Near You
Who Is Running the Clinical Trial?
Medical College of Wisconsin
Lead Sponsor