Clarinex

Catarrh, Asthma, nasal symptoms + 6 more
Treatment
9 FDA approvals
20 Active Studies for Clarinex

What is Clarinex

DesloratadineThe Generic name of this drug
Treatment SummaryDesloratadine is a type of antihistamine used to treat allergies. It works by blocking the action of histamines, the chemical released during an allergic reaction. Desloratadine is the active form of loratidine and has a longer-lasting effect than other antihistamines, without causing drowsiness because it does not enter the brain.
Clarinexis the brand name
image of different drug pills on a surface
Clarinex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clarinex
Desloratadine
2001
35

Approved as Treatment by the FDA

Desloratadine, also known as Clarinex, is approved by the FDA for 9 uses like Seasonal Allergic Rhinitis and Chronic Idiopathic Urticaria .
Seasonal Allergic Rhinitis
Chronic Idiopathic Urticaria
nasal symptoms
Used to treat nasal symptoms in combination with Pseudoephedrine
non-nasal symptoms
Used to treat non-nasal symptoms in combination with Pseudoephedrine
Perennial Allergic Rhinitis (PAR)
Nasal Congestion
Used to treat Nasal Congestion in combination with Pseudoephedrine
Hay Fever
Chronic Urticaria
Rhinitis, Allergic

Effectiveness

How Clarinex Affects PatientsDesloratadine is an anti-allergy medication that stops the effects of histamine, a chemical that causes many symptoms associated with allergies like tissue swelling. It works by blocking one type of receptor that histamine attaches to on cells, which prevents cells from being activated. Desloratadine does not enter the brain, so it does not make people feel sleepy, unlike some other antihistamines.
How Clarinex works in the bodyDesloratadine is an antihistamine that works by blocking histamine from binding to certain receptors in the body. This action stops the negative symptoms caused by histamine, like congestion and watery eyes.

When to interrupt dosage

The measure of Clarinex relies upon the diagnosed situation, including Hay Fever, Nasal Congestion and non-nasal symptoms. The amount of dosage fluctuates as per the method of delivery (e.g. Oral or Tablet, orally disintegrating - Oral) specified in the table beneath.
Condition
Dosage
Administration
Catarrh
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
Chronic Urticaria
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
Asthma
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
Hay Fever
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
Nasal Congestion
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
Rhinitis, Allergic
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
non-nasal symptoms
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical
antihistamine
, 5.0 mg, 2.5 mg, 0.5 mg/mL
Tablet, film coated - Oral, , Tablet, film coated, Oral, Tablet, extended release - Oral, Solution - Oral, Solution, Tablet, extended release, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release - Oral, Tablet, film coated, extended release, Kit - Topical, Kit, Topical

Warnings

Clarinex Contraindications
Condition
Risk Level
Notes
Pulse Frequency
Do Not Combine
There are 20 known major drug interactions with Clarinex.
Common Clarinex Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.
Clarinex Toxicity & Overdose RiskDesloratadine overdose can lead to drowsiness. Treatment involves removing the drug that was not absorbed and providing supportive care. In experiments on animals, doses of 250mg/kg in rats or 353mg/kg in mice were fatal, which would be 120-290 times the recommended dose for humans. No deaths were reported in monkeys at doses of up to 250mg/kg, which is 810 times the recommended dose for humans.
image of a doctor in a lab doing drug, clinical research

Clarinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Clarinex?

153 active studies are presently investigating the potential of Clarinex to provide relief from Asthma, Catarrh and Hay Fever.
Condition
Clinical Trials
Trial Phases
Asthma
92 Actively Recruiting
Phase 1, Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 3
antihistamine
0 Actively Recruiting
Catarrh
0 Actively Recruiting
nasal symptoms
0 Actively Recruiting
Nasal Congestion
0 Actively Recruiting
Hay Fever
0 Actively Recruiting
Chronic Urticaria
0 Actively Recruiting
non-nasal symptoms
0 Actively Recruiting
Rhinitis, Allergic
0 Actively Recruiting

Clarinex Reviews: What are patients saying about Clarinex?

5Patient Review
5/18/2009
Clarinex for Seasonal Runny Nose
I'm really glad we found this medication, it's been effective in preventing my daughter's coughing spells. The only downside is that it dries her nose out, but we've just been giving it to her at bedtime and so far it hasn't been a problem.
5Patient Review
6/4/2009
Clarinex for Persistent Hives of Unknown Cause
I'm so grateful for this medication! I had to take two days off of work because my allergies were so bad, but this cleared me up within 5 minutes.
5Patient Review
4/30/2009
Clarinex for Non-Seasonal Allergic Runny Nose
Unfortunately, this medication had the opposite of the intended effect on me. My nose ran constantly after taking it, rather than stopping a runny nose from a cold. I won't be taking any more of these pills.
5Patient Review
2/5/2014
Clarinex for Seasonal Runny Nose
Clarinex has been a life-saver for me during allergy season. It's the only medication that has worked for me, and I've tried several other brands over the years. If you're struggling with pollen allergies, I highly recommend giving Clarinex a try.
5Patient Review
6/29/2009
Clarinex for Seasonal Runny Nose
We tried this for ten days on a sample we got from the pediatric allergist. We had ten uninerrupted nights' sleep and good reports at school. When we ran out of Clarinex we went to Zyrtec as recommended and the difference was like night and day, Clarinex works, period.
5Patient Review
5/4/2010
Clarinex for Inflammation of the Nose due to an Allergy
I was on Allegra for years and it wasn't working anymore. I used this in combination with my nasal spray and it works well--no side effects.
5Patient Review
12/10/2013
Clarinex for Inflammation of the Nose due to an Allergy
I've only just started taking this medication, but it seems to be working just as well as Claritin did for me.
4.7Patient Review
4/28/2010
Clarinex for Persistent Hives of Unknown Cause
This medication really helped with my runny nose without making me feel drowsy or exhausted. I haven't experienced many negative side effects, if any at all. Additionally, I believe it works better than other similar medications on the market.
3.7Patient Review
8/2/2009
Clarinex for Inflammation of the Nose due to an Allergy
Clarinex is the only medication that has been effective for me in treating my hives. I've tried a lot of other treatments and nothing has worked as well as this one.
3Patient Review
2/2/2012
Clarinex for Inflammation of the Nose due to an Allergy
I've suffered from incessant itching for a long time, and it was really getting unbearable. Thankfully, I found some relief in taking clarinex (desloratadine). It's not perfect, but it's helped me immensely.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about clarinex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Clarinex and Zyrtec the same?

"Clarinex (desloratadine) is a good choice for those who want to take an allergy medication once a day. It is less likely to cause drowsiness than other options, but you need a prescription. It is effective in relieving congestion and other allergy symptoms. Zyrtec D (cetirizine / pseudoephedrine) is another option that relieves allergies and congestion without causing drowsiness."

Answered by AI

What is Clarinex prescribed for?

"Desloratadine is an antihistamine that is used to relieve various allergy symptoms. These symptoms include watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Desloratadine works by blocking histamine, which is a natural substance that your body creates during an allergic reaction."

Answered by AI

Are Claritin and Clarinex the same?

"The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex.

Are Claritin and Clarinex majorly different?

Claritin is loratadine and Clarinex is desloratadine. Loratadine is metabolized in the liver to produce desloratadine. The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex."

Answered by AI

Clinical Trials for Clarinex

Have you considered Clarinex clinical trials? We made a collection of clinical trials featuring Clarinex, we think they might fit your search criteria.Go to Trials
Image of Allergy Immunology Associates in Mayfield Heights, United States.

Osteopathic Manipulative Treatment for Asthma

18 - 60
All Sexes
Mayfield Heights, OH
Asthma is a common respiratory condition that can be difficult to control despite the use of medications such as inhalers, oral steroids or even injectable medications. Osteopathic Manipulative Treatment (OMT) is a hands-on technique used to improve the chest structure and function and may help in improving breathing. Previous research showed that OMT in asthma patients, can improve the movement of the ribs and improve the "peak flow" which is the maximum rate at which a person can exhale air after taking a deep breath. However, no studies have evaluated the impact of OMT on lung inflammation. This single-site research study at University Hospitals aims to evaluate whether Osteopathic Manipulative Treatment (OMT) can reduce lung inflammation and improve breathing and lung function in adult patients with asthma. The lung function will be evaluated by Spirometry which is a test that measures how much air you can breathe in and out of your lungs, as well as how quickly and easily you can exhale air. The lung inflammation will be measured using a device that can detect how much you are breathing out Nitric Oxide which is a gas produced by inflamed cells in the lungs, this test is called: Fractional exhaled Nitric Oxide or FeNO. Approximately 100 participants will be enrolled.
Waitlist Available
Has No Placebo
Allergy Immunology AssociatesNancy Wasserbauer-Kingston, DO
Image of DARTNet Institute in Aurora, United States.

Inhaled Corticosteroids + Azithromycin for Asthma

13 - 75
All Sexes
Aurora, CO
While asthma therapy is becoming more individualized based on asthma phenotypes, more research is needed to tailor newer therapies to individuals. Inhaled corticosteroid (ICS) medications are the foundation of care for all individuals with persistent asthma. But ICS use is not without possible long term side effects. This study will compare two currently available approaches to reduce AEX in primary care patients: (1) use of inhaled corticosteroids (ICS) as part of rescue therapy, also known as MART (Maintenance And Reliever Therapy) or PARTICS (Patient Activated Reliever Trigger Inhaled Corticosteriods) therapy - either of these therapies will be called Rescue-Inhaled Corticosteroids or R-ICS pronounced "Ricks," and (2) use of azithromycin (AZ) as a preventive therapy. These treatments will be studied both individually and in combination.
Phase 4
Recruiting
DARTNet Institute (+12 Sites)Wilson D Pace, MD, FAAFP
Image of Medical Place Pharmacy in Ajax, Canada.

Pharmacy Support System for Asthma

Any Age
All Sexes
Ajax, Canada
The goal of this study is to assess the effect of an electronic asthma management system in pharmacies (eAMS-Pharm) on asthma control assessment, asthma medication adjustment, asthma action plan delivery, and prompting for specialist referral in severe asthma. The study assesses the differences on pharmacy processes (affecting both the pharmacy team and patients) and pharmacy-delivered care using an interrupted time-series analysis (six-months before vs. six-months after the introduction of eAMS-Pharm in study pharmacy sites). The eAMS-Pharm uses patient data (asthma control, asthma flare-up risk, and current medications) to provide clinical decision support to pharmacists, empowering them to bridge existing gaps between guideline-recommended asthma care and patient care received.
Waitlist Available
Has No Placebo
Medical Place Pharmacy (+2 Sites)
Image of St. Paul's Hospital in Vancouver, Canada.

Salbutamol for Athletic Performance

18 - 55
All Sexes
Vancouver, Canada
β2-Agonists, commonly used to treat asthma, have also been used by athletes to enhance performance, leading to their ban by the International Olympic Committee in 1972. Research has shown non-asthmatics receive no benefit from these drugs at therapeutic dosages; however, many elite athletes still use them, and asthmatic athletes often win more Olympic medals. In some non-asthmatics, β2-agonists may improve breathing limitations during high intensity exercise, which may improve performance. Therefore, we aim to examine if there is a select group of non-asthmatic individuals who experience breathing limitations that may receive benefit from β2-agonists.
Waitlist Available
Paid Trial
St. Paul's HospitalJordan A Guenette, PhD
Have you considered Clarinex clinical trials? We made a collection of clinical trials featuring Clarinex, we think they might fit your search criteria.Go to Trials
Image of Velocity Clinical Research, Mobile in Mobile, United States.

PF-07275315 for Asthma

18 - 70
All Sexes
Mobile, AL
The purpose of this clinical trial is to learn about the safety and effects of the study medicine (called PF-07275315) for the potential treatment of moderate-to-severe asthma. Asthma is a condition that makes it challenging to breathe, which negatively impacts the quality of life and functioning of people who are affected. This study is seeking participants who: * Are 18 to 70 years old * Have had moderate-to-severe asthma for at least 12 months that is not well controlled * Have been taking their regular maintenance treatment(s) for asthma over the last 12 months All participants will receive PF-07275315 or a placebo. A placebo does not have any medicine in it but looks just like the medicine being studied. PF-07275315 or placebo will be given as multiple shots in the clinic over the course of 12 weeks. We will compare the experiences of people receiving PF-07275315 to those of the people who do not. This will help us determine if PF-07275315 is safe and effective. Participants will be involved in this study for about 9.5 months. During this time, they will have 10 visits at the study clinic.
Phase 2
Recruiting
Velocity Clinical Research, Mobile (+10 Sites)Pfizer CT.gov Call CenterPfizer
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Corticosteroids for Asthma

18+
All Sexes
Hamilton, Canada
Most individuals with asthma can effectively manage their symptoms and maintain normal lung function using inhaled medications, unfortunately, there is a subset of asthma sufferers whose symptoms, lung function, and risk of asthma attacks remain unimproved despite conventional inhaled medications. There could be several reasons for this. One possibility is that inhaled medications fail to reach the intended areas within the lungs, due to structural abnormalities within the airways themselves. Much like road conditions or closures can impede the speed and efficiency of vehicle travel, factors such as airway narrowing or mucus blockages, which are common in asthma, can obstruct the passage of inhaled medications through the airways. Our team has now optimized advanced medical imaging techniques, including magnetic resonance imaging (MRI) and computed tomography (CT), required to investigate this. This study will use these imaging methods to visually assess and measure individual patients' airways and determine whether abnormal airway structures impact how well they respond to inhaled and orally delivered medications. We anticipate finding that abnormal airway structures make inhaled medications less effective, but that they do not affect the response to oral medications.
Phase 4
Recruiting
St. Joseph's Healthcare Hamilton (+1 Sites)
Have you considered Clarinex clinical trials? We made a collection of clinical trials featuring Clarinex, we think they might fit your search criteria.Go to Trials
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