Clarinex

Catarrh, Asthma, nasal symptoms + 6 more

Treatment

9 FDA approvals

20 Active Studies for Clarinex

Treatment for

Catarrh

What is Clarinex

DesloratadineThe Generic name of this drug

Treatment SummaryDesloratadine is a type of antihistamine used to treat allergies. It works by blocking the action of histamines, the chemical released during an allergic reaction. Desloratadine is the active form of loratidine and has a longer-lasting effect than other antihistamines, without causing drowsiness because it does not enter the brain.

Clarinexis the brand name

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Clarinex Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Clarinex

Desloratadine

2001

Approved as Treatment by the FDA

Desloratadine, also known as Clarinex, is approved by the FDA for 9 uses like Seasonal Allergic Rhinitis and Chronic Idiopathic Urticaria .

Seasonal Allergic Rhinitis

Chronic Idiopathic Urticaria

nasal symptoms

Used to treat nasal symptoms in combination with Pseudoephedrine

non-nasal symptoms

Used to treat non-nasal symptoms in combination with Pseudoephedrine

Perennial Allergic Rhinitis (PAR)

Nasal Congestion

Used to treat Nasal Congestion in combination with Pseudoephedrine

Hay Fever

Chronic Urticaria

Rhinitis, Allergic

Effectiveness

How Clarinex Affects PatientsDesloratadine is an anti-allergy medication that stops the effects of histamine, a chemical that causes many symptoms associated with allergies like tissue swelling. It works by blocking one type of receptor that histamine attaches to on cells, which prevents cells from being activated. Desloratadine does not enter the brain, so it does not make people feel sleepy, unlike some other antihistamines.

How Clarinex works in the bodyDesloratadine is an antihistamine that works by blocking histamine from binding to certain receptors in the body. This action stops the negative symptoms caused by histamine, like congestion and watery eyes.

When to interrupt dosage

The measure of Clarinex relies upon the diagnosed situation, including Hay Fever, Nasal Congestion and non-nasal symptoms. The amount of dosage fluctuates as per the method of delivery (e.g. Oral or Tablet, orally disintegrating - Oral) specified in the table beneath.

Condition

Dosage

Administration

Catarrh

, 5.0 mg, 2.5 mg, 0.5 mg/mL

, Oral, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release, Tablet, extended release - Oral, Solution, Solution - Oral, Tablet, Tablet - Oral, Tablet, orally disintegrating, Tablet, orally disintegrating - Oral, Syrup - Oral, Syrup, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Kit, Topical, Kit - Topical

Chronic Urticaria

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Asthma

, 5.0 mg, 2.5 mg, 0.5 mg/mL

nasal symptoms

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Hay Fever

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Nasal Congestion

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Rhinitis, Allergic

, 5.0 mg, 2.5 mg, 0.5 mg/mL

non-nasal symptoms

, 5.0 mg, 2.5 mg, 0.5 mg/mL

antihistamine

, 5.0 mg, 2.5 mg, 0.5 mg/mL

Warnings

Clarinex Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Clarinex.

Common Clarinex Drug Interactions

Drug Name

Risk Level

Description

Amiodarone

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.

Anagrelide

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.

Arsenic trioxide

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.

Artemether

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.

Asenapine

Major

The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.

Clarinex Toxicity & Overdose RiskDesloratadine overdose can lead to drowsiness. Treatment involves removing the drug that was not absorbed and providing supportive care. In experiments on animals, doses of 250mg/kg in rats or 353mg/kg in mice were fatal, which would be 120-290 times the recommended dose for humans. No deaths were reported in monkeys at doses of up to 250mg/kg, which is 810 times the recommended dose for humans.

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Clarinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Clarinex?

153 active studies are presently investigating the potential of Clarinex to provide relief from Asthma, Catarrh and Hay Fever.

Condition

Clinical Trials

Trial Phases

Asthma

87 Actively Recruiting

Phase 4, Early Phase 1, Phase 2, Not Applicable, Phase 1, Phase 3

antihistamine

0 Actively Recruiting

Catarrh

0 Actively Recruiting

nasal symptoms

0 Actively Recruiting

Nasal Congestion

0 Actively Recruiting

Hay Fever

0 Actively Recruiting

Chronic Urticaria

1 Actively Recruiting

Phase 2

non-nasal symptoms

0 Actively Recruiting

Rhinitis, Allergic

0 Actively Recruiting

Clarinex Reviews: What are patients saying about Clarinex?

5Patient Review

5/18/2009

Clarinex for Seasonal Runny Nose

I'm really glad we found this medication, it's been effective in preventing my daughter's coughing spells. The only downside is that it dries her nose out, but we've just been giving it to her at bedtime and so far it hasn't been a problem.

5Patient Review

6/4/2009

Clarinex for Persistent Hives of Unknown Cause

I'm so grateful for this medication! I had to take two days off of work because my allergies were so bad, but this cleared me up within 5 minutes.

5Patient Review

4/30/2009

Clarinex for Non-Seasonal Allergic Runny Nose

Unfortunately, this medication had the opposite of the intended effect on me. My nose ran constantly after taking it, rather than stopping a runny nose from a cold. I won't be taking any more of these pills.

5Patient Review

2/5/2014

Clarinex for Seasonal Runny Nose

Clarinex has been a life-saver for me during allergy season. It's the only medication that has worked for me, and I've tried several other brands over the years. If you're struggling with pollen allergies, I highly recommend giving Clarinex a try.

5Patient Review

6/29/2009

Clarinex for Seasonal Runny Nose

We tried this for ten days on a sample we got from the pediatric allergist. We had ten uninerrupted nights' sleep and good reports at school. When we ran out of Clarinex we went to Zyrtec as recommended and the difference was like night and day, Clarinex works, period.

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Patient Q&A Section about clarinex

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is Clarinex and Zyrtec the same?

"Clarinex (desloratadine) is a good choice for those who want to take an allergy medication once a day. It is less likely to cause drowsiness than other options, but you need a prescription. It is effective in relieving congestion and other allergy symptoms. Zyrtec D (cetirizine / pseudoephedrine) is another option that relieves allergies and congestion without causing drowsiness."

Answered by AI

What is Clarinex prescribed for?

"Desloratadine is an antihistamine that is used to relieve various allergy symptoms. These symptoms include watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Desloratadine works by blocking histamine, which is a natural substance that your body creates during an allergic reaction."

Answered by AI

Are Claritin and Clarinex the same?

"The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex.

Are Claritin and Clarinex majorly different?

Claritin is loratadine and Clarinex is desloratadine. Loratadine is metabolized in the liver to produce desloratadine. The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex."

Answered by AI

Clinical Trials for Clarinex

Have you considered Clarinex clinical trials? We made a collection of clinical trials featuring Clarinex, we think they might fit your search criteria.

Have you considered Clarinex clinical trials? We made a collection of clinical trials featuring Clarinex, we think they might fit your search criteria.