What is Clarinex
DesloratadineThe Generic name of this drug
Treatment SummaryDesloratadine is a type of antihistamine used to treat allergies. It works by blocking the action of histamines, the chemical released during an allergic reaction. Desloratadine is the active form of loratidine and has a longer-lasting effect than other antihistamines, without causing drowsiness because it does not enter the brain.
Clarinexis the brand name
Clarinex Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Clarinex
Desloratadine
2001
35
Approved as Treatment by the FDA
Desloratadine, also known as Clarinex, is approved by the FDA for 6 uses like Chronic Urticaria and Nasal Congestion .Chronic Urticaria
Nasal Congestion
Used to treat Nasal Congestion in combination with Pseudoephedrine
nasal symptoms
Used to treat nasal symptoms in combination with Pseudoephedrine
Hay Fever
non-nasal symptoms
Used to treat non-nasal symptoms in combination with Pseudoephedrine
Perennial Allergic Rhinitis (PAR)
Effectiveness
How Clarinex Affects PatientsDesloratadine is an anti-allergy medication that stops the effects of histamine, a chemical that causes many symptoms associated with allergies like tissue swelling. It works by blocking one type of receptor that histamine attaches to on cells, which prevents cells from being activated. Desloratadine does not enter the brain, so it does not make people feel sleepy, unlike some other antihistamines.
How Clarinex works in the bodyDesloratadine is an antihistamine that works by blocking histamine from binding to certain receptors in the body. This action stops the negative symptoms caused by histamine, like congestion and watery eyes.
When to interrupt dosage
The measure of Clarinex relies upon the diagnosed situation, including Hay Fever, Nasal Congestion and non-nasal symptoms. The amount of dosage fluctuates as per the method of delivery (e.g. Oral or Tablet, orally disintegrating - Oral) specified in the table beneath.Condition
Dosage
Administration
Chronic Urticaria
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Asthma
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Hay Fever
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Nasal Congestion
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
non-nasal symptoms
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Hay Fever
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
antihistamine
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Perennial Allergic Rhinitis (PAR)
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
nasal symptoms
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Catarrh
0.5 mg/mL, 5.0 mg, , 2.5 mg
Oral, Tablet, orally disintegrating - Oral, Tablet - Oral, Tablet, orally disintegrating, Tablet, multilayer, extended release, Tablet, film coated, extended release - Oral, , Tablet, multilayer, extended release - Oral, Solution, Kit - Topical, Tablet, film coated, Tablet, film coated - Oral, Tablet, extended release - Oral, Topical, Tablet, extended release, Tablet, film coated, extended release, Kit, Solution - Oral, Tablet, Syrup - Oral, Syrup
Warnings
Clarinex ContraindicationsCondition
Risk Level
Notes
Toxoplasma Infections
Do Not Combine
Common Clarinex Drug Interactions
Drug Name
Risk Level
Description
Amiodarone
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Amiodarone.
Anagrelide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Anagrelide.
Arsenic trioxide
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Arsenic trioxide.
Artemether
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Artemether.
Asenapine
Major
The risk or severity of QTc prolongation can be increased when Desloratadine is combined with Asenapine.
Clarinex Toxicity & Overdose RiskDesloratadine overdose can lead to drowsiness. Treatment involves removing the drug that was not absorbed and providing supportive care. In experiments on animals, doses of 250mg/kg in rats or 353mg/kg in mice were fatal, which would be 120-290 times the recommended dose for humans. No deaths were reported in monkeys at doses of up to 250mg/kg, which is 810 times the recommended dose for humans.
Clarinex Novel Uses: Which Conditions Have a Clinical Trial Featuring Clarinex?
153 active studies are presently investigating the potential of Clarinex to provide relief from Asthma, Catarrh and Hay Fever.Condition
Clinical Trials
Trial Phases
Asthma
152 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 4, Phase 3, Early Phase 1
Catarrh
2 Actively Recruiting
Phase 2, Not Applicable
Hay Fever
3 Actively Recruiting
Phase 1, Not Applicable, Phase 2
non-nasal symptoms
0 Actively Recruiting
Hay Fever
3 Actively Recruiting
Phase 3
antihistamine
0 Actively Recruiting
Nasal Congestion
1 Actively Recruiting
Not Applicable
Chronic Urticaria
1 Actively Recruiting
Phase 4
nasal symptoms
0 Actively Recruiting
Perennial Allergic Rhinitis (PAR)
0 Actively Recruiting
Clarinex Reviews: What are patients saying about Clarinex?
5Patient Review
5/18/2009 I'm really glad we found this medication, it's been effective in preventing my daughter's coughing spells. The only downside is that it dries her nose out, but we've just been giving it to her at bedtime and so far it hasn't been a problem.
5Patient Review
6/4/2009 I'm so grateful for this medication! I had to take two days off of work because my allergies were so bad, but this cleared me up within 5 minutes.
5Patient Review
4/30/2009 Unfortunately, this medication had the opposite of the intended effect on me. My nose ran constantly after taking it, rather than stopping a runny nose from a cold. I won't be taking any more of these pills.
5Patient Review
2/5/2014 Clarinex has been a life-saver for me during allergy season. It's the only medication that has worked for me, and I've tried several other brands over the years. If you're struggling with pollen allergies, I highly recommend giving Clarinex a try.
5Patient Review
6/29/2009 We tried this for ten days on a sample we got from the pediatric allergist. We had ten uninerrupted nights' sleep and good reports at school. When we ran out of Clarinex we went to Zyrtec as recommended and the difference was like night and day, Clarinex works, period.
5Patient Review
5/4/2010 I was on Allegra for years and it wasn't working anymore. I used this in combination with my nasal spray and it works well--no side effects.
5Patient Review
12/10/2013 I've only just started taking this medication, but it seems to be working just as well as Claritin did for me.
4.7Patient Review
4/28/2010 This medication really helped with my runny nose without making me feel drowsy or exhausted. I haven't experienced many negative side effects, if any at all. Additionally, I believe it works better than other similar medications on the market.
3.7Patient Review
8/2/2009 Clarinex is the only medication that has been effective for me in treating my hives. I've tried a lot of other treatments and nothing has worked as well as this one.
3Patient Review
2/2/2012 I've suffered from incessant itching for a long time, and it was really getting unbearable. Thankfully, I found some relief in taking clarinex (desloratadine). It's not perfect, but it's helped me immensely.
Patient Q&A Section about clarinex
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Clarinex and Zyrtec the same?
"Clarinex (desloratadine) is a good choice for those who want to take an [allergy](https://www.withpower.com/clinical-trials/allergy) medication once a day. It is less likely to cause drowsiness than other options, but you need a prescription. It is effective in relieving congestion and other allergy symptoms. Zyrtec D (cetirizine / pseudoephedrine) is another option that relieves allergies and congestion without causing drowsiness."
Answered by AI
What is Clarinex prescribed for?
"Desloratadine is an antihistamine that is used to relieve various [allergy](https://www.withpower.com/clinical-trials/allergy) symptoms. These symptoms include watery eyes, runny nose, itching eyes/nose, sneezing, hives, and itching. Desloratadine works by blocking histamine, which is a natural substance that your body creates during an allergic reaction."
Answered by AI
Are Claritin and Clarinex the same?
"The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex.
Are Claritin and Clarinex majorly different?
Claritin is loratadine and Clarinex is desloratadine. Loratadine is metabolized in the liver to produce desloratadine. The FDA originally approved loratadine, which was marketed as Claritin, in 1993. In 2002, the FDA approved desloratadine, which was marketed as Clarinex."
Answered by AI