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P-QST to Predict Pain Treatment Response in Chronic Pancreatitis (P-QST Trial)

N/A

Recruiting

Led By Anna Evans Phillips, MD, MS

Research Sponsored by University of Pittsburgh

Eligibility Criteria Checklist

Specific guidelines that determine who can or cannot participate in a clinical trial

Must have

Adult patients ≥ 18 years of age with definite CP undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain

Surgery: drainage procedures (Frey and Puestow operations)

Timeline

Screening 3 weeks

Treatment Varies

Follow Up baseline, 3, 6, and 12 months

Awards & highlights

P-QST Trial Summary

This trial will test whether a new assessment of neurosensory phenotyping can predict which patients with chronic pancreatitis will respond best to endoscopic therapy or surgery.

Who is the study for?

This trial is for adults over 18 with chronic pancreatitis (CP) experiencing pain, who are scheduled for specific invasive treatments to clear blockages in the pancreatic duct. Eligible patients haven't had endoscopic therapy in the past year and have no other chronic pain conditions or prior pancreatic surgery.Check my eligibility

What is being tested?

The study tests Pancreatic Quantitative Sensory Testing (P-QST), a new method to predict if patients with CP will feel less pain after undergoing certain medical procedures like endoscopy or drainage surgeries.See study design

What are the potential side effects?

Since P-QST is a diagnostic procedure rather than a drug, it may cause discomfort during testing. However, there are no direct side effects from P-QST itself as it's used to measure sensory response and predict treatment outcomes.

P-QST Trial Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below

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I am an adult with chronic pancreatitis, getting treatment to relieve duct blockage.

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I have had surgery to drain my pancreas.

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I have undergone or will undergo a procedure to remove blockages in my pancreas.

P-QST Trial Timeline

Screening ~ 3 weeks3 visits

Treatment ~ Varies

Follow Up ~ 3, 6, and 12 months

Screening ~ 3 weeks

Treatment ~ Varies

Follow Up ~3, 6, and 12 months

This trial's timeline: 3 weeks for screening, Varies for treatment, and 3, 6, and 12 months for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.

Primary outcome measures

Average Pain Score

Secondary outcome measures

Pain

Change from baseline in Single-question NRS score

Change from baseline on the Comprehensive Pain Assessment Tool for Pancreatitis Short Form (COMPAT-SF)

+13 more

P-QST Trial Design

1Treatment groups

Experimental Treatment

Group I: Pancreatic Quantitative Sensory Testing (P-QST)Experimental Treatment3 Interventions

Definite Chronic Pancreatitis patients undergoing decompressive invasive treatments (endoscopic therapy or surgery) to relieve main pancreatic duct obstruction due to stones and/or stricture for management of pain will undergo P-QST prior to clinically-indicated invasive treatment.

0 / 3Eligibility criteria met

Find a Location

Who is running the clinical trial?

University of PittsburghLead Sponsor

1,722 Previous Clinical Trials

16,342,796 Total Patients Enrolled

16 Trials studying Chronic Pain

128,866 Patients Enrolled for Chronic Pain

National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)NIH

2,359 Previous Clinical Trials

4,314,441 Total Patients Enrolled

6 Trials studying Chronic Pain

1,243 Patients Enrolled for Chronic Pain

Anna Evans Phillips, MD, MSPrincipal InvestigatorUniversity of Pittsburgh

Media Library

Quantitative Sensory Test 2 Clinical Trial Eligibility Overview. Trial Name: NCT04996628 — N/A

Chronic Pain Research Study Groups: Pancreatic Quantitative Sensory Testing (P-QST)

Chronic Pain Clinical Trial 2023: Quantitative Sensory Test 2 Highlights & Side Effects. Trial Name: NCT04996628 — N/A

Quantitative Sensory Test 2 2023 Treatment Timeline for Medical Study. Trial Name: NCT04996628 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

How many participants are currently enrolled in this research project?

"Indeed, the information provided on clinicaltrials.gov affirms that this medical investigation is currently recruiting patients. The trial was initially posted on April 1st 2022 and has been revised more recently on January 17th of the same year. A total of 150 volunteers need to be enrolled from two locations."

Answered by AI

Are there any vacancies open to partake in this clinical investigation?

"According to the clinicaltrials.gov registry, this experiment is actively seeking potential subjects. The trial was initially created on April 1st 2022 with a recent update on January 17th 2021."

Answered by AI

Recent research and studies

clinicaltrials.govStudy

Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis

Anna Evans Phillips 2022. "Pancreatic Quantitative Sensory Testing (P-QST) to Predict Treatment Response for Pain in Chronic Pancreatitis". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04996628.

All > Chronic Pancreatitis > Chronic Pain