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What is Lastacaft
AlcaftadineThe Generic name of this drug
Treatment SummaryAlcaftadine is a medication used to prevent itchy eyes caused by allergic conjunctivitis. It works by blocking histamine, a chemical that causes allergic reactions. Alcaftadine was approved by the FDA in 2010.
Lastacaftis the brand name
Lastacaft Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Lastacaft
Alcaftadine
2010
5
Effectiveness
How Lastacaft Affects PatientsAfter being applied to the eyes, alcaftadine ophthalmic solution, 0.25%, reaches its highest level in the blood (60 pg/mL) in 15 minutes. The level of alcaftadine in the blood drops below 10 pg/mL after 3 hours. Its active carboxylic acid metabolite has a peak level in the blood of 3 ng/mL after 1 hour and drops below 100 pg/mL after 12 hours.
How Lastacaft works in the bodyAlcaftadine works by blocking the effects of histamine, which is a chemical released by certain cells in the body. It also stops white blood cells from moving to the area and stops them from becoming activated.
When to interrupt dosage
The quantity of Lastacaft is contingent upon the diagnosed affliction. The dosage fluctuates as per the method of delivery (e.g. Ophthalmic or Solution / drops) featured in the table beneath.Condition
Dosage
Administration
Allergic Conjunctivitis (AC)
, 2.5 mg/mL
, Ophthalmic, Solution / drops, Solution / drops - Ophthalmic, Solution, Solution - Ophthalmic
Warnings
There are 6 known major drug interactions with Lastacaft.Common Lastacaft Drug Interactions
Drug Name
Risk Level
Description
Hydroxyzine
Major
The risk or severity of QTc prolongation can be increased when Alcaftadine is combined with Hydroxyzine.
Ziprasidone
Major
The risk or severity of QTc prolongation can be increased when Alcaftadine is combined with Ziprasidone.
Fexinidazole
Moderate
The risk or severity of adverse effects can be increased when Alcaftadine is combined with Fexinidazole.
Haloperidol
Moderate
The risk or severity of QTc prolongation can be increased when Alcaftadine is combined with Haloperidol.
Hyoscyamine
Moderate
Alcaftadine may increase the anticholinergic activities of Hyoscyamine.
Lastacaft Novel Uses: Which Conditions Have a Clinical Trial Featuring Lastacaft?
Three active studies are currently assessing the potential of Lastacaft to provide relief from Allergic Conjunctivitis (AC).Condition
Clinical Trials
Trial Phases
Allergic Conjunctivitis (AC)
1 Actively Recruiting
Phase 2
Lastacaft Reviews: What are patients saying about Lastacaft?
5Patient Review
9/7/2013 My wife and I both used this medication for our allergies, but we both had burning eyes and swollen, red, irritated eyes the next day. We were very uncomfortable and stopped using it after one day.
5Patient Review
8/17/2014 It's important to remember that every person reacts differently to medication. The doctor is essentially conducting an experiment whenever they prescribe a new drug, and even they can't predict how someone will react. I hope for the best but understand that not everyone will have the same experience with this treatment.
3.7Patient Review
8/7/2014 The drops are good, but I think Allergan is ripping people off with the price. The container is tiny and only holds a few drops, yet they charge an absurd amount of money for it. It's outrageous.
3.3Patient Review
7/27/2014 Though it did work well to clear my infection, I lost a concerning amount of eyelashes after just three uses. Will not be using this product again.
2.7Patient Review
12/25/2020 It's quite expensive, and insurance only covered a fraction of the cost. I find it outrageous that they charge so much for such a small amount.
2.3Patient Review
7/31/2014 I used this for about two weeks before I started having problems with my eyes. They turned red and swollen, to the point where I thought I might have an infection. However, after reading some other reviews, it seems like this drug may have been the cause of my issues.
2.3Patient Review
2/20/2014 I didn't love this treatment because it made me feel really bloated and my eyes were red.
2.3Patient Review
9/1/2015 After using this drug for a while, it started to make my eye problem worse. I stopped using it for a couple months and saw gradual improvement, but when I recently tried again, I had an intense reaction where my eyes burned and became red and swollen. It's clearly not the right medication for me.
2.3Patient Review
8/26/2013 It did stop the itching and irritation in my eye.
2.3Patient Review
7/13/2014 The first two weeks were great while using the sample, but ever since I purchased the prescription, it seems that my eyes have been burning, feeling dry and irritated, and are red more than usual. I had to stop the eye drops and am hopeful the symptoms resolve.
1.7Patient Review
9/3/2022 I had the worst allergic reaction of my life to this drug. I was itchy and red all over for a month, and then my throat started swelling and I couldn't breathe. My eyes were also incredibly swollen and itchy.
1Patient Review
7/7/2012 This is the first eye drop that has actually worked well for me. I would recommend it to others in a similar situation.
Patient Q&A Section about lastacaft
These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.Is Lastacaft discontinued?
"Is Lastacaft (alcaftadine) now available over the counter? It wasn't before, but it has been FDA approved for over-the-counter use now."
Answered by AI
Which is better Pataday or Lastacaft?
"Lastacaft was better tolerated than Pataday.
The study showed that Lastacaft was more effective than Pataday for ocular itching in grass- and tree-allergic subjects, and that it was better tolerated."
Answered by AI
What is Lastacaft used for?
"This medication is used to prevent itching of the eyes due to allergies. Alcaftadine is an antihistamine. It works by blocking the natural substance histamine that causes allergic symptoms.Do not use this medication to treat red or irritated eyes due to wearing contact lenses."
Answered by AI
Is Lastacaft a mast cell stabilizer?
"Alcaftadine is a broad-spectrum antihistamine that has a high affinity for histamine H1 and H2 receptors, a lower affinity for H4 receptors, and also exhibits modulatory action on immune cell recruitment and mast cell stabilizing effects."
Answered by AI