Hydroxyzine Pamoate

Neurotic Disorders, Generalized Anxiety Disorder, Itching + 5 more
Treatment
8 FDA approvals
20 Active Studies for Hydroxyzine Pamoate

What is Hydroxyzine Pamoate

HydroxyzineThe Generic name of this drug
Treatment SummaryHydroxyzine is a type of antihistamine that helps reduce symptoms of allergies, such as itching, hives, and rashes. It can also be used to treat anxiety disorders and tension. It was first developed in 1955 and is still commonly used today. The active ingredient in hydroxyzine, cetirizine, is also used in other allergy medications.
Vistarilis the brand name
image of different drug pills on a surface
Hydroxyzine Pamoate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vistaril
Hydroxyzine
1957
585

Approved as Treatment by the FDA

Hydroxyzine, also known as Vistaril, is approved by the FDA for 8 uses which include Itching and histamine .
Itching
histamine
Allergic Conditions
Neurotic Disorders
Generalized Anxiety Disorder
Nausea
Nausea
Surgical and medical procedures

Effectiveness

How Hydroxyzine Pamoate Affects PatientsHydroxyzine helps reduce symptoms of allergies such as itching, and can also be used as a sedative and anti-nausea medication. It usually starts working within 15-60 minutes and can last for 4-6 hours. It may increase the effects of other medicines that cause drowsiness, so patients should be carefully monitored after receiving general anesthesia. Hydroxyzine can also interfere with the heart's electrical activity, which can lead to serious heart problems, so it should be used cautiously in those with an increased risk of such problems.
How Hydroxyzine Pamoate works in the bodyHydroxyzine is a medicine used to treat allergic reactions. It works by blocking the histamine H1 receptor, which is responsible for causing allergic symptoms like itching, sneezing, and watery eyes. Hydroxyzine also has sedative and anti-nausea effects, which are thought to come from blocking other receptors in the body.

When to interrupt dosage

The suggested dosage of Hydroxyzine Pamoate is contingent upon the diagnosed condition, including Allergic Conditions, Neurotic Disorders and Nausea. The amount of dosage is contingent upon the method of delivery highlighted in the following table.
Condition
Dosage
Administration
Allergic Conditions
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Generalized Anxiety Disorder
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Surgical and medical procedures
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Itching
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
histamine
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Neurotic Disorders
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Nausea
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Nausea
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual

Warnings

Hydroxyzine Pamoate Contraindications
Condition
Risk Level
Notes
Cardiac Arrhythmia
Do Not Combine
Pulse Frequency
Do Not Combine
Pregnancy Trimester, First
Do Not Combine
Sudden Cardiac Death
Do Not Combine
Porphyria
Do Not Combine
history of QT prolongation
Do Not Combine
Asthma
Do Not Combine
Bradycardia
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Electrolyte imbalance
Do Not Combine
history of torsade de pointes
Do Not Combine
Severe Hypersensitivity Reactions
Do Not Combine
Hydroxyzine may interact with Pulse Frequency
There are 20 known major drug interactions with Hydroxyzine Pamoate.
Common Hydroxyzine Pamoate Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Hydroxyzine.
Azelastine
Major
Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Hydroxyzine.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Hydroxyzine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Hydroxyzine.
Hydroxyzine Pamoate Toxicity & Overdose RiskThe lowest toxic dose of hydroxyzine in rats has been found to be 840 mg/kg and 400 mg/kg in mice. Symptoms of overdose include excessive sedation, seizures, confusion, nausea, and vomiting. Treatment involves inducing vomiting and providing general supportive care. Low blood pressure may be treated with intravenous fluids, and caffeine and sodium benzoate can be administered to reduce the effects of CNS depressants. Dialysis is unlikely to help with hydroxyzine overdose.
image of a doctor in a lab doing drug, clinical research

Hydroxyzine Pamoate Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydroxyzine Pamoate?

At present, 229 active clinical trials are being conducted to investigate the potential of Hydroxyzine Pamoate to treat Generalized Anxiety Disorder, Surgical and medical procedures, as well as Itch.
Condition
Clinical Trials
Trial Phases
Nausea
0 Actively Recruiting
Surgical and medical procedures
0 Actively Recruiting
Neurotic Disorders
0 Actively Recruiting
Nausea
0 Actively Recruiting
Generalized Anxiety Disorder
244 Actively Recruiting
Not Applicable, Phase 1, Phase 2, Phase 3, Early Phase 1, Phase 4
histamine
0 Actively Recruiting
Allergic Conditions
0 Actively Recruiting
Itching
11 Actively Recruiting
Phase 2, Phase 4, Phase 3, Phase 1

Hydroxyzine Pamoate Reviews: What are patients saying about Hydroxyzine Pamoate?

5Patient Review
12/26/2021
Hydroxyzine Pamoate for Inducing of a Relaxed Easy State
This treatment has been a godsend for my insomnia and anxiety. Taking a low dose of 10mg every 2 weeks seems to be the sweet spot for me in terms of effectiveness. I wish I had found this sooner!
5Patient Review
4/7/2022
Hydroxyzine Pamoate for Anxious
I find that this medication really helps me to fall asleep and stay asleep for a good 6-8 hours. Before taking it, my mind would never stop racing and I had a lot of trouble falling asleep.
5Patient Review
1/2/2018
Hydroxyzine Pamoate for Anxious
This treatment had similar effects to marijuana in terms of calming me down.
5Patient Review
3/7/2021
Hydroxyzine Pamoate for Additional Medication for Calming
This medicine has been a life-saver for me. I take it as an emergency anxiety medicine and also at bedtime. Normally, I experience crippling anxiety attacks when heading to bed. However, while taking this medicine, it calms me down and allows me to fall asleep faster without the rushing thoughts. I was prescribed to take this one to two times daily, and I am on 50MG. Although if you take it late at night you may experience drowsiness in the morning.
5Patient Review
1/2/2018
Hydroxyzine Pamoate for Anxious
This medication had effects similar to marijuana, in that it calmed me down.
5Patient Review
3/7/2021
Hydroxyzine Pamoate for Additional Medication for Calming
This medicine has been a lifesaver for me. I take it as an emergency anxiety medicine and also at bedtime, and it really helps me to calm down and fall asleep faster. I was prescribed to take this one to two times daily, and I'm currently on 50MG. If you take it late at night, you may experience drowsiness in the morning.
5Patient Review
12/26/2021
Hydroxyzine Pamoate for Inducing of a Relaxed Easy State
This treatment helped me a lot with my insomnia. I was taking a low dose of 10mg every two weeks, and it really made a difference. I wish I had started using it sooner.
5Patient Review
4/7/2022
Hydroxyzine Pamoate for Anxious
I have a lot of trouble shutting off my brain when it's time to sleep, but this medication really helps. I can usually get six to eight hours of solid rest after taking just one 25mg pill.
4.7Patient Review
6/28/2021
Hydroxyzine Pamoate for Anxious
This medication has been incredibly helpful for my anxiety. It's helped me to keep things at a manageable level, and I haven't experienced any negative effects that outweigh the positives.
4.7Patient Review
8/23/2017
Hydroxyzine Pamoate for Anxious
When I have anxiety-induced twitches and itches, this is my go-to medication and it always does the trick.
4.7Patient Review
7/22/2021
Hydroxyzine Pamoate for Anxious
Within an hour of taking this, my anxiety symptoms were either completely relieved or at least significantly reduced. It also helped me sleep through the night, which is a huge plus.
4.7Patient Review
7/22/2021
Hydroxyzine Pamoate for Anxious
I found that this treatment quickly (within an hour) reduced or eliminated my anxiety symptoms. It also helped me sleep better and stay asleep throughout the night, which was a huge relief.
4.7Patient Review
8/23/2017
Hydroxyzine Pamoate for Anxious
This treatment is effective for twitches and itches that come as a result of anxiety. I only use it when needed, and it always provides relief. Not sure why people would take this medication for depression or anxiety instead of other options, but if you're just looking for something to stop the itch, this definitely does the trick.
4.7Patient Review
6/28/2021
Hydroxyzine Pamoate for Anxious
Out of all the medications I've tried for anxiety, this one is by far the best. It's non-habit forming and fast acting, with only minor side effects. I would highly recommend it to anyone dealing with anxiety.
4.3Patient Review
10/31/2022
Hydroxyzine Pamoate for Anxious
This medication has been very helpful in managing my anxiety. It's not a perfect solution, but it definitely takes the edge off and allows me to function. I would recommend it for people with mild anxiety disorders.
4.3Patient Review
10/31/2022
Hydroxyzine Pamoate for Anxious
This medication has been very helpful in managing the anxiety I experience from my autism, ADHD, and bipolar disorder. I use it as needed (usually most days of the month) and it definitely makes a difference. It might make some people sleepy, but I'm able to function on it just fine. Overall, would recommend for mild anxiety.
4Patient Review
1/31/2020
Hydroxyzine Pamoate for Anxious
This medication was effective in helping me sleep and keeping my anxiety at bay. I like that I don't have to take it every day, and can just use it as needed.
4Patient Review
1/31/2020
Hydroxyzine Pamoate for Anxious
This medication was really helpful in terms of getting me to sleep and calming me down. I liked that I didn't need to take it every day, but rather only as needed.
3Patient Review
6/19/2017
Hydroxyzine Pamoate for Anxious
This medication is helpful for calming my anxiety attacks, but it sometimes doesn't work if I wait too long to take it. It's also been prescribed to me as-needed, up to twice daily.
3Patient Review
6/19/2017
Hydroxyzine Pamoate for Anxious
This medication usually does the trick in terms of calming me down from anxiety attacks. However, if I wait too long to take it, it becomes less effective. Also, I was prescribed to take it one to two times daily as needed for my anxiety disorder.
2.7Patient Review
12/16/2021
Hydroxyzine Pamoate for Anxious
I was prescribed 25mg as needed of this medication, but it has caused me a great deal of tension and pressure in the back of my head, difficulty concentrating, and anxiety. I only took it for two days because of these episodes, but I've been dealing with the side effects ever since.
2.7Patient Review
12/16/2021
Hydroxyzine Pamoate for Anxious
I was prescribed 25mg of this medication to take as needed, but it has only caused me more anxiety. I took the pill for two days straight and have been dealing with its side effects ever since.
1Patient Review
10/14/2021
Hydroxyzine Pamoate for Inducing of a Relaxed Easy State
I was prescribed this after being taken off of clonazepam, which actually worked for me. This medication does nothing in comparison and the withdrawal from clonazepam has been incredibly difficult. I haven't slept more than an hour or two since stopping that medicine, and my anxiety is through the roof. Doctors are quick to prescribe this as a replacement for something that actually works because they're afraid of addiction, but all this has done is make me miserable.
1Patient Review
5/1/2018
Hydroxyzine Pamoate for Inflammation of Skin caused by an Allergy
Unfortunately, this medication did not help me with either my allergies or anxiety.
1Patient Review
5/1/2018
Hydroxyzine Pamoate for Inflammation of Skin caused by an Allergy
This treatment did nothing to help my allergies or anxiety.
1Patient Review
10/14/2021
Hydroxyzine Pamoate for Inducing of a Relaxed Easy State
I was really struggling after being taken off of clonazepam. This medication did nothing to help me with my anxiety or insomnia. It's been brutal trying to withdraw. I don't understand why doctors are so afraid of addiction when this has been such a nightmare.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about hydroxyzine pamoate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is hydroxyzine pamoate used for?

"Hydroxyzine is used to treat itching resulting from allergies. By blocking histamine, it functions as an antihistamine to alleviate allergic reactions."

Answered by AI

Is hydroxyzine pamoate the same as Xanax?

"These drugs work by different mechanisms, but both have anti-anxiety effects.

The drugs Vistaril and Xanax are both used to treat anxiety, though they work via different mechanisms. Vistaril is an antihistamine with drying and sedative properties, while Xanax is a benzodiazepine. Though their means of anxious relief differ, both drugs are effective."

Answered by AI

Is hydroxyzine pamoate good for anxiety?

"Vistaril is used as a short-term treatment for anxiety symptoms or as an alternative to habit-forming anxiety medications such as benzodiazepines. It is also prescribed as an antihistamine to treat skin allergies, so it can be a good choice for people who have both allergies and anxiety."

Answered by AI

Is hydroxyzine pamoate a sleeping pill?

"Hydroxyzine is an antihistamine that is approved for the treatment of anxiety. However, it is also used to treat difficulty sleeping, nausea, vomiting, itching, skin rash, and allergies."

Answered by AI

Clinical Trials for Hydroxyzine Pamoate

Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.
Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.
Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.