Hydroxyzine Pamoate

Neurotic Disorders, Generalized Anxiety Disorder, Itching + 5 more
Treatment
13 FDA approvals
20 Active Studies for Hydroxyzine Pamoate

What is Hydroxyzine Pamoate

HydroxyzineThe Generic name of this drug
Treatment SummaryHydroxyzine is a type of antihistamine that helps reduce symptoms of allergies, such as itching, hives, and rashes. It can also be used to treat anxiety disorders and tension. It was first developed in 1955 and is still commonly used today. The active ingredient in hydroxyzine, cetirizine, is also used in other allergy medications.
Vistarilis the brand name
image of different drug pills on a surface
Hydroxyzine Pamoate Overview & Background
Brand Name
Generic Name
First FDA Approval
How many FDA approvals?
Vistaril
Hydroxyzine
1957
585

Approved as Treatment by the FDA

Hydroxyzine, also known as Vistaril, is approved by the FDA for 13 uses which include Nausea and Neurotic Disorders .
Nausea
Neurotic Disorders
Generalized Anxiety Disorder
Nausea and vomiting
Nausea and Vomiting of Pregnancy
Pruritus
Allergic Conditions
Surgical and medical procedures
Nausea
Itching
Hypersensitivity
Neurotic Disorders
histamine

Effectiveness

How Hydroxyzine Pamoate Affects PatientsHydroxyzine helps reduce symptoms of allergies such as itching, and can also be used as a sedative and anti-nausea medication. It usually starts working within 15-60 minutes and can last for 4-6 hours. It may increase the effects of other medicines that cause drowsiness, so patients should be carefully monitored after receiving general anesthesia. Hydroxyzine can also interfere with the heart's electrical activity, which can lead to serious heart problems, so it should be used cautiously in those with an increased risk of such problems.
How Hydroxyzine Pamoate works in the bodyHydroxyzine is a medicine used to treat allergic reactions. It works by blocking the histamine H1 receptor, which is responsible for causing allergic symptoms like itching, sneezing, and watery eyes. Hydroxyzine also has sedative and anti-nausea effects, which are thought to come from blocking other receptors in the body.

When to interrupt dosage

The suggested dosage of Hydroxyzine Pamoate is contingent upon the diagnosed condition, including Allergic Conditions, Neurotic Disorders and Nausea. The amount of dosage is contingent upon the method of delivery highlighted in the following table.
Condition
Dosage
Administration
Surgical and medical procedures
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Itching
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Nausea
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Generalized Anxiety Disorder
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Nausea
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Hypersensitivity
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
Neurotic Disorders
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual
histamine
, 50.0 mg/mL, 10.0 mg/mL, 25.0 mg, 10.0 mg, 50.0 mg, 25.0 mg/mL, 100.0 mg, 5.0 mg/mL
, Intramuscular, Solution, Solution - Intramuscular, Syrup, Syrup - Oral, Oral, Tablet, film coated, Tablet, film coated - Oral, Capsule, Capsule - Oral, Solution - Oral, Tablet, Tablet - Oral, Injection, solution, Injection, solution - Intramuscular, Liquid - Intramuscular, Liquid, Suspension - Oral, Suspension, Troche, Sublingual, Troche - Sublingual

Warnings

Hydroxyzine Pamoate Contraindications
Condition
Risk Level
Notes
Severe Hypersensitivity Reactions
Do Not Combine
Hydroxyzine may interact with Pulse Frequency
Cardiac Arrhythmia
Do Not Combine
Pulse Frequency
Do Not Combine
Pregnancy Trimester, First
Do Not Combine
Sudden Cardiac Death
Do Not Combine
Porphyrias
Do Not Combine
Long QT Syndrome
Do Not Combine
Asthma
Do Not Combine
Bradycardia
Do Not Combine
Pulse Frequency
Do Not Combine
Pulse Frequency
Do Not Combine
Electrolyte imbalance
Do Not Combine
Torsades de Pointes
Do Not Combine
There are 20 known major drug interactions with Hydroxyzine Pamoate.
Common Hydroxyzine Pamoate Drug Interactions
Drug Name
Risk Level
Description
Axitinib
Major
The metabolism of Axitinib can be decreased when combined with Hydroxyzine.
Azelastine
Major
Hydroxyzine may increase the central nervous system depressant (CNS depressant) activities of Azelastine.
Cabazitaxel
Major
The metabolism of Cabazitaxel can be decreased when combined with Hydroxyzine.
Copanlisib
Major
The metabolism of Copanlisib can be decreased when combined with Hydroxyzine.
Cyclophosphamide
Major
The metabolism of Cyclophosphamide can be decreased when combined with Hydroxyzine.
Hydroxyzine Pamoate Toxicity & Overdose RiskThe lowest toxic dose of hydroxyzine in rats has been found to be 840 mg/kg and 400 mg/kg in mice. Symptoms of overdose include excessive sedation, seizures, confusion, nausea, and vomiting. Treatment involves inducing vomiting and providing general supportive care. Low blood pressure may be treated with intravenous fluids, and caffeine and sodium benzoate can be administered to reduce the effects of CNS depressants. Dialysis is unlikely to help with hydroxyzine overdose.
image of a doctor in a lab doing drug, clinical research

Hydroxyzine Pamoate Novel Uses: Which Conditions Have a Clinical Trial Featuring Hydroxyzine Pamoate?

At present, 229 active clinical trials are being conducted to investigate the potential of Hydroxyzine Pamoate to treat Generalized Anxiety Disorder, Surgical and medical procedures, as well as Itch.
Condition
Clinical Trials
Trial Phases
Generalized Anxiety Disorder
208 Actively Recruiting
Phase 3, Not Applicable, Phase 2, Early Phase 1, Phase 4, Phase 1
histamine
0 Actively Recruiting
Itching
3 Actively Recruiting
Phase 2, Phase 3, Not Applicable
Nausea
0 Actively Recruiting
Nausea
0 Actively Recruiting
Neurotic Disorders
0 Actively Recruiting
Surgical and medical procedures
0 Actively Recruiting
Hypersensitivity
0 Actively Recruiting

Hydroxyzine Pamoate Reviews: What are patients saying about Hydroxyzine Pamoate?

5Patient Review
12/26/2021
Hydroxyzine Pamoate for Inducing of a Relaxed Easy State
This treatment has been a godsend for my insomnia and anxiety. Taking a low dose of 10mg every 2 weeks seems to be the sweet spot for me in terms of effectiveness. I wish I had found this sooner!
5Patient Review
4/7/2022
Hydroxyzine Pamoate for Anxious
I find that this medication really helps me to fall asleep and stay asleep for a good 6-8 hours. Before taking it, my mind would never stop racing and I had a lot of trouble falling asleep.
5Patient Review
1/2/2018
Hydroxyzine Pamoate for Anxious
This treatment had similar effects to marijuana in terms of calming me down.
5Patient Review
3/7/2021
Hydroxyzine Pamoate for Additional Medication for Calming
This medicine has been a life-saver for me. I take it as an emergency anxiety medicine and also at bedtime. Normally, I experience crippling anxiety attacks when heading to bed. However, while taking this medicine, it calms me down and allows me to fall asleep faster without the rushing thoughts. I was prescribed to take this one to two times daily, and I am on 50MG. Although if you take it late at night you may experience drowsiness in the morning.
5Patient Review
1/2/2018
Hydroxyzine Pamoate for Anxious
This medication had effects similar to marijuana, in that it calmed me down.
View All Reviews
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Patient Q&A Section about hydroxyzine pamoate

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is hydroxyzine pamoate used for?

"Hydroxyzine is used to treat itching resulting from allergies. By blocking histamine, it functions as an antihistamine to alleviate allergic reactions."

Answered by AI

Is hydroxyzine pamoate the same as Xanax?

"These drugs work by different mechanisms, but both have anti-anxiety effects.

The drugs Vistaril and Xanax are both used to treat anxiety, though they work via different mechanisms. Vistaril is an antihistamine with drying and sedative properties, while Xanax is a benzodiazepine. Though their means of anxious relief differ, both drugs are effective."

Answered by AI

Is hydroxyzine pamoate good for anxiety?

"Vistaril is used as a short-term treatment for anxiety symptoms or as an alternative to habit-forming anxiety medications such as benzodiazepines. It is also prescribed as an antihistamine to treat skin allergies, so it can be a good choice for people who have both allergies and anxiety."

Answered by AI

Is hydroxyzine pamoate a sleeping pill?

"Hydroxyzine is an antihistamine that is approved for the treatment of anxiety. However, it is also used to treat difficulty sleeping, nausea, vomiting, itching, skin rash, and allergies."

Answered by AI

Clinical Trials for Hydroxyzine Pamoate

Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.
Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.
Have you considered Hydroxyzine Pamoate clinical trials? We made a collection of clinical trials featuring Hydroxyzine Pamoate, we think they might fit your search criteria.
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