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Cognitive Rehabilitation for Schizophrenia and Depression

N/A
Recruiting
Led By Synthia Guimond, PhD
Research Sponsored by The Royal Ottawa Mental Health Centre
Eligibility Criteria Checklist
Specific guidelines that determine who can or cannot participate in a clinical trial
Must have
Age between 18-45 years
A diagnosis of schizophrenia, schizoaffective or major depression disorder
Timeline
Screening 3 weeks
Treatment Varies
Follow Up baseline, mid-treatment (3 weeks) and post treatment (7 weeks)
Awards & highlights

Study Summary

This trial will assess the efficacy of a cognitive rehabilitation intervention on verbal memory and emotion regulation in patients with schizophrenia and depression. The goal is to improve cognitive functioning and community functioning in these patients.

Who is the study for?
This trial is for adults aged 18-45 with schizophrenia, schizoaffective disorder, or major depression who have been on stable medication for over a month. Participants must have an IQ above 70 and be fluent in English. It's not suitable for those with cognitive impairments from medical conditions, under guardianship due to decisional incapacity, MRI contraindications, recent substance abuse, or taking certain anticholinergic or daily benzodiazepine medications.Check my eligibility
What is being tested?
The study tests a cognitive rehabilitation intervention aimed at improving verbal memory and emotion regulation in patients with schizophrenia and depression. The effectiveness will be measured by changes in cognition, brain function, community functioning, symptom severity, and perceived cognitive deficits.See study design
What are the potential side effects?
Since the interventions are non-medical (cognitive exercises), traditional drug side effects are not expected. However participants may experience fatigue or frustration during tasks designed to challenge their cognitive abilities.

Eligibility Criteria

Inclusion Criteria

You may be eligible if you check “Yes” for the criteria below
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I am between 18 and 45 years old.
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I have been diagnosed with schizophrenia, schizoaffective disorder, or major depression.

Timeline

Screening ~ 3 weeks
Treatment ~ Varies
Follow Up ~baseline, mid-treatment (3 weeks) and post treatment (7 weeks)
This trial's timeline: 3 weeks for screening, Varies for treatment, and baseline, mid-treatment (3 weeks) and post treatment (7 weeks) for reporting.

Treatment Details

Study Objectives

Outcome measures can provide a clearer picture of what you can expect from a treatment.
Primary outcome measures
Change in emotion regulation performance from baseline - Mayer-Salovey-Caruso Emotional Intelligence Test (MSECIT)
Body Weight Changes
Secondary outcome measures
Change in brain activity from baseline
Change in composite scores on cognitive assessments from baseline
Other outcome measures
Change in composite scores on social functioning from baseline
Change in perceived cognitive impairments from baseline - Subjective Scale to Investigate Cognition in Schizophrenia - Brief (SSTICS-B)
Change in symptom severity from baseline - Positive and Negative Syndrome Scale (PANSS)

Trial Design

2Treatment groups
Experimental Treatment
Active Control
Group I: Cognitive InterventionExperimental Treatment1 Intervention
Group II: Active Control InterventionActive Control1 Intervention
Treatment
First Studied
Drug Approval Stage
How many patients have taken this drug
Cognitive Intervention
2016
N/A
~1120

Find a Location

Who is running the clinical trial?

The Royal Ottawa Mental Health CentreLead Sponsor
18 Previous Clinical Trials
2,000 Total Patients Enrolled
4 Trials studying Depression
523 Patients Enrolled for Depression
Synthia Guimond, PhDPrincipal InvestigatorRoyal Ottawa Mental Health Centre
2 Previous Clinical Trials
82 Total Patients Enrolled

Media Library

Cognitive Intervention Clinical Trial Eligibility Overview. Trial Name: NCT04159662 — N/A
Depression Research Study Groups: Cognitive Intervention, Active Control Intervention
Depression Clinical Trial 2023: Cognitive Intervention Highlights & Side Effects. Trial Name: NCT04159662 — N/A
Cognitive Intervention 2023 Treatment Timeline for Medical Study. Trial Name: NCT04159662 — N/A

Frequently Asked Questions

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.
Recent research and studies
clinicaltrials.govStudy
Cognitive Rehabilitation in Schizophrenia and Depression
Synthia Guimond 2019. "Cognitive Rehabilitation in Schizophrenia and Depression". ClinicalTrials.gov. https://clinicaltrials.gov/ct2/show/NCT04159662.
~34 spots leftby Oct 2026
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