Triazolam

Insomnia, Sedation, Sedation therapy

Treatment

1 FDA approval

2 Active Studies for Triazolam

What is Triazolam

Triazolam

The Generic name of this drug

Treatment Summary

Triazolam is a medication available in the United States that is used to treat insomnia. In other countries, it is classified as a Schedule IV drug under international law. It has been withdrawn in the United Kingdom due to potential risks of psychological side effects.

Halcion

is the brand name

image of different drug pills on a surface

Triazolam Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Halcion

Triazolam

1982

37

Approved as Treatment by the FDA

Triazolam, also called Halcion, is approved by the FDA for 1 uses including Insomnia .

Insomnia

Effectiveness

How Triazolam Affects Patients

Triazolam is a short-acting drug used as a sleeping aid. Some countries have taken it off the market due to potential psychological side effects with higher doses. However, it has been approved for use in lower doses when taken properly. Triazolam works faster than other similar drugs, and does not create any active byproducts in the body.

How Triazolam works in the body

Benzodiazepines work by targeting two types of receptors. The first, BNZ1, helps with sleep, while the second, BNZ2, is responsible for muscle relaxation and other functions. These receptors are linked to GABA receptors, which help regulate nerve activity. When benzodiazepines target these receptors, it increases the effect of GABA, which makes the nerve cells less excitable and prevents further stimulation.

When to interrupt dosage

The proposed measure of Triazolam is contingent upon the diagnosed state, which may include Sedation, Insomnia and Sedation therapy. The amount also varies as per the technique of administration (e.g. Tablet or Oral) detailed in the table below.

Condition

Dosage

Administration

Sedation

0.125 mg, , 0.25 mg

, Tablet - Oral, Oral, Tablet

Insomnia

0.125 mg, , 0.25 mg

, Tablet - Oral, Oral, Tablet

Sedation therapy

0.125 mg, , 0.25 mg

, Tablet - Oral, Oral, Tablet

Warnings

Triazolam Contraindications

Condition

Risk Level

Notes

Pulse Frequency

Do Not Combine

There are 20 known major drug interactions with Triazolam.

Common Triazolam Drug Interactions

Drug Name

Risk Level

Description

Astemizole

Major

The metabolism of Astemizole can be decreased when combined with Triazolam.

Axitinib

Major

The metabolism of Axitinib can be decreased when combined with Triazolam.

Azelastine

Major

Triazolam may increase the central nervous system depressant (CNS depressant) activities of Azelastine.

Cabazitaxel

Major

The metabolism of Cabazitaxel can be decreased when combined with Triazolam.

Carbamazepine

Major

The metabolism of Carbamazepine can be decreased when combined with Triazolam.

Triazolam Toxicity & Overdose Risk

Overdosing on Xanax can lead to drowsiness, difficulty speaking, difficulty with movement, coma, and difficulty breathing.

image of a doctor in a lab doing drug, clinical research

Triazolam Novel Uses: Which Conditions Have a Clinical Trial Featuring Triazolam?

83 active clinical trials are presently assessing the effects of Triazolam for Insomnia, Sedation and Sedative Therapy.

Condition

Clinical Trials

Trial Phases

Insomnia

0 Actively Recruiting

Sedation

2 Actively Recruiting

Early Phase 1, Not Applicable

Sedation therapy

0 Actively Recruiting

Triazolam Reviews: What are patients saying about Triazolam?

5

Patient Review

4/25/2013

Triazolam for Chronic Trouble Sleeping

I'm able to sleep so much better at night thanks to Triazolam. I wake up feeling rested and more energetic. I also feel more balanced throughout the day.

5

Patient Review

11/21/2012

Triazolam for Chronic Trouble Sleeping

4.7

Patient Review

12/23/2017

Triazolam for Chronic Trouble Sleeping

I started sleepwalking after taking this medication, which I had never done before. Once I stopped taking the medicine, the sleepwalking stopped as well. Be aware that if you take this drug, you may start sleepwalking without realizing it.

4.3

Patient Review

2/2/2018

Triazolam for Chronic Trouble Sleeping

Quick-acting and usually puts me to sleep for three to five hours. I take it occasionally when I wake up in the middle of the night or have to fly long distances; however, like most sleep medications, it can become difficult to fall asleep without it after using it for a few days in a row.

4.3

Patient Review

5/5/2018

Triazolam for Chronic Trouble Sleeping

I've been cutting and using 0.25 for years, but it doesn't always help. I want to stop taking it altogether.

4.3

Patient Review

9/29/2014

Triazolam for Chronic Trouble Sleeping

This treatment helps me sleep soundly through the night, and I always feel refreshed and well-rested in the morning.

4.3

Patient Review

12/30/2013

Triazolam for Chronic Trouble Sleeping

I experienced some significant side effects from this medication, including extreme weight gain, dizziness, and difficulty breathing. However, it was effective in treating my condition.

3

Patient Review

10/8/2013

Triazolam for Chronic Trouble Sleeping

I don't understand why Walgreens only gives out 15 tablets at a time. This has been an issue for me for over a year now, and it's especially difficult to get my hands on the medication if there are fewer days in the month. Can anything be done about this?

3

Patient Review

3/7/2013

Triazolam for Chronic Trouble Sleeping

I find that I fall asleep soon after taking this pill.

2.7

Patient Review

1/21/2017

Triazolam for Chronic Trouble Sleeping

Works well with no side effects; guarantees a good night's sleep. Half dosage is useless.

2.7

Patient Review

8/24/2012

Triazolam for Chronic Trouble Sleeping

2.7

Patient Review

9/14/2015

Triazolam for Chronic Trouble Sleeping

The dosage for this medication is tricky to adjust. I also found that it caused me to be not in control of my cognition for several hours after taking it, which made dental procedures difficult.

1.7

Patient Review

3/1/2013

Triazolam for Chronic Trouble Sleeping

1.3

Patient Review

9/19/2015

Triazolam for Chronic Trouble Sleeping

I was pretty naive when I started this treatment, thinking that my lack of sleep had nothing to do with my sedentary lifestyle. The doctor told me that insomnia wasn't a symptom of anything else, so I just went along with it and took the pill he prescribed. But of course, the pill didn't work, and now I realize that exercise is key to a good night's sleep.
image of drug pills surrounding a glass of water symbolizing drug consumption

Patient Q&A Section about triazolam

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

What is the medication triazolam used for?

"Triazolam is a short-term treatment for insomnia. It belongs to a group of medicines called central nervous system (CNS) depressants, which slow down the nervous system."

Answered by AI

Is triazolam the same as Xanax?

"Triazolam is a drug that can help people who have trouble sleeping. It belongs to a group of drugs called benzodiazepines, which also includes drugs like Valium, Xanax, Klonopin, and Ativan."

Answered by AI

How quickly does triazolam work?

"Approximately how long does it take for triazolam to take effect and how long does the effect usually last? It takes triazolam (Halcion) 15 to 30 minutes to take effect, and the effect usually lasts for 6 to 7 hours."

Answered by AI

Is triazolam a narcotic?

"Triazolam is a controlled substance that has been assigned to Schedule IV under the Controlled Substance Act."

Answered by AI

Clinical Trials for Triazolam

Image of CAMC Memorial in Charleston, United States.

Ketamine vs Fentanyl for Sedation in Interventional Radiology

18 - 90
All Sexes
Charleston, WV

This study aims to reduce pain during interventional radiology (IR) procedures, making the experience better for patients. Typically, doctors use medications like fentanyl and midazolam for sedation. This research will focus on patients undergoing biopsies and drainage procedures, often associated with significant discomfort. Patients will be randomly assigned to receive either fentanyl/midazolam or ketamine/midazolam combinations for sedation. A coordinator will collect information on pain levels and satisfaction, as well as monitor any extra medications needed and side effects. The investigators hope to find that ketamine helps decrease pain and improves satisfaction compared to fentanyl, without increasing complications.

Phase < 1
Recruiting

CAMC Memorial

Amy R Deipolyi, M.D., Ph.D.