Antitussive

Sneezing, Chronic Pain, Catarrh + 31 more

Treatment

1 FDA approval

20 Active Studies for Antitussive

Treatment for

Sneezing

What is Antitussive

Pseudoephedrine

The Generic name of this drug

Treatment Summary

Dextromethorphan is a medication used to suppress coughing. It is similar in structure to other opioids, but it has a limited effect on opioid receptors. It was approved by the FDA in 1957 and can be found in many over-the-counter cold and cough medications.

Nasal Decongestant Maximum Strength

is the brand name

Antitussive Overview & Background

Brand Name

Generic Name

First FDA Approval

How many FDA approvals?

Nasal Decongestant Maximum Strength

Pseudoephedrine

1981

547

Approved as Treatment by the FDA

Pseudoephedrine, also known as Nasal Decongestant Maximum Strength, is approved by the FDA for 1 uses including Nasal Congestion .

Nasal Congestion

Effectiveness

How Antitussive Affects Patients

Dextromethorphan is a drug used in combination with other medications to treat coughing and a condition called pseudobulbar affect. It is important to take the proper dose, as taking too much can cause intoxication. The effects of Dextromethorphan last for a moderate amount of time, so patients should be aware of the potential risks.

How Antitussive works in the body

Dextromethorphan works by interacting with certain receptors in the body. It stimulates some receptors, like NMDA and sigma-1, while blocking others, like alpha3/beta4 nicotinic receptors. We don't know exactly how this translates to a clinical effect.

When to interrupt dosage

The measure of Antitussive is contingent upon the recognized condition, including Coughing, Fever and Antisepsis. The dosage changes as per the technique of administration depicted in the table beneath.

Condition

Dosage

Administration

Catarrh

60.0 mg, , 120.0 mg, 240.0 mg, 30.0 mg, 6.0 mg/mL, 3.0 mg/mL, 15.0 mg/mL, 30.0 mg/mL, 60.0 mg/mL, 10.0 mg/mL, 20.0 mg/mL, 40.0 mg, 50.0 mg/mL, 14.998 mg/mL, 15.001 mg/mL, 0.3 mg/mg, 0.15 mg/mg, 7.5 mg/mL, 25.0 mg, 45.0 mg/mL, 15.0 mg, 7.5 mg, 9.38 mg/mL, 20.0 mg, 45.0 mg, 4.0 mg/mL, 80.0 mg, 4.5 mg/mL, 22.5 mg/mL, 14.999 mg/mL, 9.0 mg/mL, 8.0 mg/mL, 12.5 mg/mL, 25.0 mg/mL, 180.0 mg, 0.6 mg/mg, 75.0 mg/mL, 0.06 mg/mg, 0.006 mg/mg

Oral, Powder, for solution - Oral, , Powder, for solution, Tablet, extended release, Tablet, extended release - Oral, Tablet, film coated - Oral, Tablet, film coated, Tablet, film coated, extended release, Tablet, film coated, extended release - Oral, Tablet, sugar coated, Tablet, sugar coated - Oral, Capsule, liquid filled - Oral, Capsule, liquid filled, Tablet, coated, Liquid - Oral, Tablet, coated - Oral, Liquid, Tablet, Tablet - Oral, Solution, Solution - Oral, Syrup - Oral, Syrup, Elixir, Elixir - Oral, Solution / drops, Solution / drops - Oral, Capsule - Oral, Capsule, Suspension, Suspension - Oral, Pill, Pill - Oral, Tablet, multilayer - Oral, Tablet, multilayer, Powder - Oral, Capsule, extended release - Oral, Capsule, extended release, Powder, Tablet, chewable, Tablet, chewable - Oral, Kit; Tablet - Oral, Tablet; Tablet, extended release - Oral, Tablet; Tablet, extended release, Kit; Tablet, Tablet, multilayer, extended release, Tablet, multilayer, extended release - Oral, Capsule; Kit, Capsule; Kit - Oral, Kit; Powder - Oral, Kit; Powder, Capsule, gelatin coated, Capsule, gelatin coated - Oral, Kit; Powder, for solution - Oral, Kit; Powder, for solution, Kit, Kit - Oral, Solution / drops - Nasal, Nasal, Tablet, for suspension - Oral, Tablet, for suspension

Priapism

Migraine

Bronchitis

Fever

Upper respiratory tract signs and symptoms

Influenza

Rhinitis, Allergic

Sneezing

Acute Bronchitis

Chronic Pain

Throat irritation

Sinusitis

Upper respiratory tract congestion

Rhinorrhea

Sinus Congestion

Coughing

Pharyngitis

Common Cold

Hypersensitivity

Warnings

Antitussive has one contraindication indicating that it should not be taken if the conditions in the following table are present.

Antitussive Contraindications

Condition

Risk Level

Notes

Coronary Artery Disease

Do Not Combine

Hypertension

Do Not Combine

Urinary Retention

Do Not Combine

Pulse Frequency

Do Not Combine

Severe Hypersensitivity Reactions

Do Not Combine

Pseudoephedrine may interact with Pulse Frequency

There are 20 known major drug interactions with Antitussive.

Common Antitussive Drug Interactions

Drug Name

Risk Level

Description

Iobenguane

Major

Pseudoephedrine can cause a decrease in the absorption of Iobenguane resulting in a reduced serum concentration and potentially a decrease in efficacy.

Methylene blue

Major

Pseudoephedrine may increase the serotonergic activities of Methylene blue.

Mirtazapine

Major

Pseudoephedrine may increase the serotonergic activities of Mirtazapine.

1-benzylimidazole

Minor

The therapeutic efficacy of 1-benzylimidazole can be decreased when used in combination with Pseudoephedrine.

4-Methoxyamphetamine

Minor

The risk or severity of hypertension can be increased when Pseudoephedrine is combined with 4-Methoxyamphetamine.

Antitussive Toxicity & Overdose Risk

Taking too much dextromethorphan can cause nausea, vomiting, loss of consciousness, difficulty breathing, seizures, rapid heartbeat, excitability, mental confusion, lack of coordination, blurred vision, changes in muscle reflexes, and a serotonin overload. Treatment for an overdose should focus on relieving the symptoms and providing support.

image of a doctor in a lab doing drug, clinical research

Antitussive Novel Uses: Which Conditions Have a Clinical Trial Featuring Antitussive?

134 active studies are presently assessing the suitability of Antitussive for Influenza, Pseudobulbar Affect (PBA) and Coughing alleviation.

Condition

Clinical Trials

Trial Phases

Chronic Pain

130 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 3, Early Phase 1, Phase 1

Sinus Congestion

0 Actively Recruiting

Throat irritation

0 Actively Recruiting

Hypersensitivity

1 Actively Recruiting

Phase 4

Acute Bronchitis

7 Actively Recruiting

Phase 4, Not Applicable, Phase 3, Early Phase 1

Sneezing

0 Actively Recruiting

Migraine

13 Actively Recruiting

Not Applicable, Phase 2, Phase 1, Phase 3, Phase 4

Pharyngitis

0 Actively Recruiting

Bronchitis

0 Actively Recruiting

Sinusitis

2 Actively Recruiting

Not Applicable

Influenza

29 Actively Recruiting

Not Applicable, Phase 4, Phase 2, Phase 1, Phase 3

Hay Fever

0 Actively Recruiting

Rhinorrhea

0 Actively Recruiting

Seasonal Allergies

0 Actively Recruiting

Fever

2 Actively Recruiting

Not Applicable, Phase 4

Perennial Allergy

0 Actively Recruiting

Coughing

0 Actively Recruiting

Common Cold

0 Actively Recruiting

Eye

0 Actively Recruiting

Coughing

0 Actively Recruiting

Antitussive Reviews: What are patients saying about Antitussive?

Patient Review

11/5/2009

Antitussive for Cough

I did feel a sense of euphoria while taking this medication, which could be addicting for some. Be mindful of that possibility if you decide to try it.

3.3

Patient Review

2/4/2015

Antitussive for Cough

I started having hearing problems on the third day. It's possible that this medication is affecting my hearing power. So far, the only other side effect I've noticed is an allergic reaction.

Patient Q&A Section about antitussive

These questions and answers are submitted by anonymous patients, and have not been verified by our internal team.

Is antitussive good for dry cough?

"Expectorants thin mucus and help your cough move it out. This works best for productive coughs caused by colds or allergies.

Cough suppressants stop your cough by making it harder for your brain to tell your body to cough. Expectorants make it easier to cough up mucus by thinning it out."

Answered by AI

What is an example of an antitussive?

"Antitussives that can be bought without a prescription and that work on the central nervous system include dextromethorphan products (Delsym, Robitussin, Vicks Formula 44, and Triaminic)."

Answered by AI

Which drug is antitussive drug?

"Guaifenesin is a medication used to thin mucus and make coughs more productive. It is commonly used to treat conditions such as the common cold, bronchitis, and other breathing illnesses."

Answered by AI

What is the most effective antitussive?

"The most effective antitussive agents are opioids. These drugs most likely act both on brainstem opioid receptors and on receptors located peripherally on sensory nerve endings in the airways."

Answered by AI