Pain Expectation Conditioning for Pain

Not yet recruiting at 1 trial location

Overseen By Jennifer Burgos-Tirado, M.Sc.A., Ing.

Age: 18 - 65

Sex: Any

Trial Phase: Academic

Sponsor: Universite de Picardie Jules Verne

No Placebo Group All trial participants will receive the active study treatment (no placebo)

Compensation: Varies

Number of Visits: Unknown

What You Need to Know Before You Apply

What is the purpose of this trial?

This study investigates how the anticipation of pain affects muscle synergies. Two groups will be compared: an experimental group, who first experience actual pain from capsaicin cream and are then presented with a harmless cream deceptively labeled as capsaicin, against a control group, who are presented with a harmless cream labeled as potentially painful, without any prior painful experience. The changes in muscle synergies will be measured during walking tasks.

Who Is on the Research Team?

Thierry Lelard, PhD, HDR

Principal Investigator

Lecturer

Maryne Cozette, PhD, Lecturer

Principal Investigator

Lecturer

Guillaume Léonard, PhD, Lecturer

Principal Investigator

Lecturer

Are You a Good Fit for This Trial?

This trial is for individuals who experience chronic surgical pain, general pain, anxiety, or are susceptible to the nocebo effect. Specific eligibility criteria have not been provided.

Inclusion Criteria

Body Mass Index (BMI) < 30

I am between 18 and 35 years old.

I do not have any diagnosed neurological, musculoskeletal, or heart conditions.

Exclusion Criteria

Pregnancy

Failure to understand instructions

Known allergy to any component of the study cream

What Are the Treatments Tested in This Trial?

Trial Overview The study examines how expecting pain can change muscle coordination during walking. One group will first feel real pain from capsaicin cream and then get a fake one labeled as painful; another gets just the fake painful cream without prior experience.

How Is the Trial Designed?

Group I: Prior Experience Group Experimental Treatment 2 Interventions

Participants in this arm have experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.

Group II: Control Group Placebo Group 2 Interventions

Pariticpants in this arm have never experienced capsaicin cream before and will be given a neutral cream. They will be told that the cream contains capsaicin and will cause pain.

Who Is Running the Clinical Trial?

Universite de Picardie Jules Verne

Lead Sponsor

Trials

2

Recruited

2,800+

Mitacs

Industry Sponsor

Trials

46

Recruited

5,200+